BACD3

Details:

UniProt Entry: Q9H3F6
Gene: KCTD10
Class: Other E3 Components
Family: Adaptor
Protein length: 313
Database confidence: 0.625
InterPro: InterPro Entry
Mode of Action: unknown
AlphaFold Model: Link

Protein Sequence ▾

>Q9H3F6
MEEMSGESVV SSAVPAAATR TTSFKGTSPS SKYVKLNVGG ALYYTTMQTL TKQDTMLKAM
FSGRMEVLTD SEGWILIDRC GKHFGTILNY LRDGAVPLPE SRREIEELLA EAKYYLVQGL
VEECQAALQN KDTYEPFCKV PVITSSKEEQ KLIATSNKPA VKLLYNRSNN KYSYTSNSDD
NMLKNIELFD KLSLRFNGRV LFIKDVIGDE ICCWSFYGQG RKIAEVCCTS IVYATEKKQT
KVEFPEARIY EETLNILLYE AQDGRGPDNA LLEATGGAAG RSHHLDEDEE RERIERVRRI
HIKRPDDRAH LHQ

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
21	290	Family	BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1/2/3	IPR045068	PTHR11145
25	135	Homologous_superfamily	SKP1/BTB/POZ domain superfamily	IPR011333	G3DSA:3.30.710.10
32	100	Domain	BTB/POZ domain	IPR000210	PS50097
32	132	Domain	BTB/POZ domain	IPR000210	SM00225
32	126	Homologous_superfamily	SKP1/BTB/POZ domain superfamily	IPR011333	SSF54695
34	124	Domain	Potassium channel tetramerisation-type BTB domain	IPR003131	PF02214

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0034220	monoatomic ion transmembrane transport	Biological Process	IEA	GO_REF:0000043
GO:0006511	ubiquitin-dependent protein catabolic process	Biological Process	IEA	GO_REF:0000117
GO:0051260	protein homooligomerization	Biological Process	IEA	GO_REF:0000002
GO:0016567	protein ubiquitination	Biological Process	ISS	GO_REF:0000024
GO:0035024	negative regulation of Rho protein signal transduction	Biological Process	IBA	GO_REF:0000033
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	Biological Process	ISS	GO_REF:0000024
GO:0005654	nucleoplasm	Cellular Component	IDA	GO_REF:0000052
GO:0005829	cytosol	Cellular Component	IDA	GO_REF:0000052
GO:0005886	plasma membrane	Cellular Component	IDA	GO_REF:0000052
GO:0005634	nucleus	Cellular Component	IEA	GO_REF:0000044
GO:0031463	Cul3-RING ubiquitin ligase complex	Cellular Component	ISS	GO_REF:0000024
GO:0004842	ubiquitin-protein transferase activity	Molecular Function	ISS	GO_REF:0000024
GO:0005112	Notch binding	Molecular Function	IPI	PMID:25401743
GO:0005515	protein binding	Molecular Function	IPI	PMID:19615732
GO:0042802	identical protein binding	Molecular Function	IPI	PMID:32296183

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