RNF39

Details:

UniProt Entry: Q9H2S5
Gene: RNF39
Class: RING
Family: RING5
Protein length: 420
Database confidence: 0.625
InterPro: InterPro Entry
Mode of Action: Standalone
AlphaFold Model: Link

Protein Sequence ▾

>Q9H2S5
MWWRDLTRLR LWLKREAIPG EGRKAAKVNA GVGEKGIYTA SSRGGPPSAR SKAVTVVAEG
AASRSWLSMD APELGPGLVE RLEQLATCPL CGGSFEDPVL LACEHSFCRA CLARRWGTPP
ATGTEASPTA CPCCGLPCPR RSLRSNVRLA VEVRISRELR EKLAEPGARA GRRRGGRIPT
MGCLDLPGED MRKTWRRFEV PTSKSSNSED DLPEDYPVVK KMLHRLTADL TLDPGTAHRR
LLISADRRSV QLAPPGTPAP PDGPKRFDQL PAVLGAQGFG AGRHCWEVET ADAASCRDSS
GEDADDEESH YAVGAAGESV QRKGCVRLCP AGAVWAVEGR GGRLWALTAP EPTLLGGVEP
PPRRIRVDLD WERGRVAFYD GRSLDLLYAF QAPGPLGERI FPLFCTCDPR APLRIVPAES

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
76	167	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
88	134	Domain	Zinc finger, RING-type	IPR001841	SM00184
88	134	Domain	Zinc finger, C3HC4 RING-type	IPR018957	PF00097
88	134	Domain	Zinc finger, RING-type	IPR001841	PS50089
103	112	Conserved_site	Zinc finger, RING-type, conserved site	IPR017907	PS00518
207	417	Homologous_superfamily	B30.2/SPRY domain superfamily	IPR043136	G3DSA:2.60.120.920
210	420	Domain	B30.2/SPRY domain	IPR001870	PS50188
221	417	Homologous_superfamily	Concanavalin A-like lectin/glucanase domain superfamily	IPR013320	SSF49899
226	243	Domain	Butyrophylin-like, SPRY domain	IPR003879	PR01407
227	280	Domain	SPRY-associated	IPR006574	SM00589
230	279	Domain	SPRY-associated	IPR006574	PF13765
243	260	Domain	Butyrophylin-like, SPRY domain	IPR003879	PR01407
266	290	Domain	Butyrophylin-like, SPRY domain	IPR003879	PR01407
281	419	Domain	SPRY domain	IPR003877	SM00449
311	324	Domain	Butyrophylin-like, SPRY domain	IPR003879	PR01407
356	380	Domain	Butyrophylin-like, SPRY domain	IPR003879	PR01407

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0002753	cytoplasmic pattern recognition receptor signaling pathway	Biological Process	IDA	PMID:23478265
GO:0032481	positive regulation of type I interferon production	Biological Process	IDA	PMID:12692549
GO:0140896	cGAS/STING signaling pathway	Biological Process	IDA	PMID:25636800
GO:0039532	negative regulation of cytoplasmic pattern recognition receptor signaling pathway	Biological Process	IDA	PMID:33674311
GO:0045087	innate immune response	Biological Process	IBA	GO_REF:0000033
GO:0070534	protein K63-linked ubiquitination	Biological Process	IDA	PMID:39255680
GO:0141111	positive regulation of cGAS/STING signaling pathway	Biological Process	IDA	PMID:39255680
GO:0005737	cytoplasm	Cellular Component	IEA	GO_REF:0000044
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0016740	transferase activity	Molecular Function	IEA	GO_REF:0000043
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0005515	protein binding	Molecular Function	IPI	PMID:32296183
GO:0061630	ubiquitin protein ligase activity	Molecular Function	IBA	GO_REF:0000033

Enzyme–Substrate Interactions ▾


O00571	DDX3X	Yes	No	No	No	—	No	E3-specific

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