GAN

Details:

UniProt Entry: Q9H2C0
Gene: GAN
Class: Other E3 Components
Family: Adaptor
Protein length: 597
Database confidence: 0.75
InterPro: InterPro Entry
Mode of Action: unknown
AlphaFold Model: Link

Protein Sequence ▾

>Q9H2C0
MAEGSAVSDP QHAARLLRAL SSFREESRFC DAHLVLDGEE IPVQKNILAA ASPYIRTKLN
YNPPKDDGST YKIELEGISV MVMREILDYI FSGQIRLNED TIQDVVQAAD LLLLTDLKTL
CCEFLEGCIA AENCIGIRDF ALHYCLHHVH YLATEYLETH FRDVSSTEEF LELSPQKLKE
VISLEKLNVG NERYVFEAVI RWIAHDTEIR KVHMKDVMSA LWVSGLDSSY LREQMLNEPL
VREIVKECSN IPLSQPQQGE AMLANFKPRG YSECIVTVGG EERVSRKPTA AMRCMCPLYD
PNRQLWIELA PLSMPRINHG VLSAEGFLFV FGGQDENKQT LSSGEKYDPD ANTWTALPPM
NEARHNFGIV EIDGMLYILG GEDGEKELIS MECYDIYSKT WTKQPDLTMV RKIGCYAAMK
KKIYAMGGGS YGKLFESVEC YDPRTQQWTA ICPLKERRFG AVACGVAMEL YVFGGVRSRE
DAQGSEMVTC KSEFYHDEFK RWIYLNDQNL CIPASSSFVY GAVPIGASIY VIGDLDTGTN
YDYVREFKRS TGTWHHTKPL LPSDLRRTGC AALRIANCKL FRLQLQQGLF RIRVHSP

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
2	580	Family	BTB-kelch protein	IPR017096	PIRSF037037
4	129	Homologous_superfamily	SKP1/BTB/POZ domain superfamily	IPR011333	G3DSA:3.30.710.10
7	126	Homologous_superfamily	SKP1/BTB/POZ domain superfamily	IPR011333	SSF54695
16	126	Domain	Gigaxonin, BTB/POZ domain	IPR047070	cd18245
21	126	Domain	BTB/POZ domain	IPR000210	PF00651
30	99	Domain	BTB/POZ domain	IPR000210	PS50097
30	129	Domain	BTB/POZ domain	IPR000210	SM00225
130	226	Domain	Gigaxonin, BACK domain	IPR030579	cd18455
134	236	Domain	BTB/Kelch-associated	IPR011705	SM00875
134	235	Domain	BTB/Kelch-associated	IPR011705	PF07707
264	574	Homologous_superfamily	Kelch-type beta propeller	IPR015915	G3DSA:2.120.10.80
274	326	Repeat	Kelch repeat type 1	IPR006652	SM00612
274	560	Homologous_superfamily	Kelch-type beta propeller	IPR015915	SSF117281
315	361	Repeat	Kelch repeat type 1	IPR006652	PF01344
327	374	Repeat	Kelch repeat type 1	IPR006652	SM00612
363	407	Repeat	Kelch repeat type 1	IPR006652	PF01344
375	421	Repeat	Kelch repeat type 1	IPR006652	SM00612
417	450	Repeat	Kelch repeat type 1	IPR006652	PF01344
422	468	Repeat	Kelch repeat type 1	IPR006652	SM00612
528	577	Repeat	Kelch repeat type 1	IPR006652	SM00612

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0007010	cytoskeleton organization	Biological Process	IEA	GO_REF:0000002
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000041
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	Biological Process	IBA	GO_REF:0000033
GO:0005737	cytoplasm	Cellular Component	IEA	GO_REF:0000120
GO:0005856	cytoskeleton	Cellular Component	IEA	GO_REF:0000120
GO:0005829	cytosol	Cellular Component	TAS	Reactome:R-HSA-8952630
GO:0031463	Cul3-RING ubiquitin ligase complex	Cellular Component	IBA	GO_REF:0000033
GO:0005515	protein binding	Molecular Function	IPI	PMID:12147674
GO:1990756	ubiquitin-like ligase-substrate adaptor activity	Molecular Function	IBA	GO_REF:0000033

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