VPS11

>Q9H270
MAAYLQWRRF VFFDKELVKE PLSNDGAAPG ATPASGSAAS KFLCLPPGIT VCDSGRGSLV
FGDMEGQIWF LPRSLQLTGF QAYKLRVTHL YQLKQHNILA SVGEDEEGIN PLVKIWNLEK
RDGGNPLCTR IFPAIPGTEP TVVSCLTVHE NLNFMAIGFT DGSVTLNKGD ITRDRHSKTQ
ILHKGNYPVT GLAFRQAGKT THLFVVTTEN VQSYIVSGKD YPRVELDTHG CGLRCSALSD
PSQDLQFIVA GDECVYLYQP DERGPCFAFE GHKLIAHWFR GYLIIVSRDR KVSPKSEFTS
RDSQSSDKQI LNIYDLCNKF IAYSTVFEDV VDVLAEWGSL YVLTRDGRVH ALQEKDTQTK
LEMLFKKNLF EMAINLAKSQ HLDSDGLAQI FMQYGDHLYS KGNHDGAVQQ YIRTIGKLEP
SYVIRKFLDA QRIHNLTAYL QTLHRQSLAN ADHTTLLLNC YTKLKDSSKL EEFIKKKSES
EVHFDVETAI KVLRQAGYYS HALYLAENHA HHEWYLKIQL EDIKNYQEAL RYIGKLPFEQ
AESNMKRYGK ILMHHIPEQT TQLLKGLCTD YRPSLEGRSD REAPGCRANS EEFIPIFANN
PRELKAFLEH MSEVQPDSPQ GIYDTLLELR LQNWAHEKDP QVKEKLHAEA ISLLKSGRFC
DVFDKALVLC QMHDFQDGVL YLYEQGKLFQ QIMHYHMQHE QYRQVISVCE RHGEQDPSLW
EQALSYFARK EEDCKEYVAA VLKHIENKNL MPPLLVVQTL AHNSTATLSV IRDYLVQKLQ
KQSQQIAQDE LRVRRYREET TRIRQEIQEL KASPKIFQKT KCSICNSALE LPSVHFLCGH
SFHQHCFESY SESDADCPTC LPENRKVMDM IRAQEQKRDL HDQFQHQLRC SNDSFSVIAD
YFGRGVFNKL TLLTDPPTAR LTSSLEAGLQ RDLLMHSRRG T

The same domains may appear in multiple rows, following InterPro convention.

Start	End	Type	Name	InterPro	Source
2	585	Family	Vacuolar protein sorting-associated protein 11	IPR016528	PIRSF007860
63	408	Homologous_superfamily	WD40/YVTN repeat-like-containing domain superfamily	IPR015943	G3DSA:2.130.10.10
76	292	Homologous_superfamily	WD40-repeat-containing domain superfamily	IPR036322	SSF50978
387	631	Homologous_superfamily	Armadillo-type fold	IPR016024	SSF48371
409	640	Homologous_superfamily	Tetratricopeptide-like helical domain superfamily	IPR011990	G3DSA:1.25.40.10
411	561	Repeat	Clathrin, heavy chain/VPS, 7-fold repeat	IPR000547	PS50236
418	536	Repeat	Clathrin, heavy chain/VPS, 7-fold repeat	IPR000547	PF00637
572	736	Repeat	Clathrin, heavy chain/VPS, 7-fold repeat	IPR000547	PS50236
577	915	Family	Vacuolar protein sorting-associated protein 11	IPR016528	PIRSF007860
808	897	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
822	860	Domain	Zinc finger, RING-type	IPR001841	PS50089
822	860	Domain	Zinc finger, RING-type	IPR001841	SM00184
864	908	Domain	Vacuolar protein sorting protein 11, C-terminal	IPR024763	PF12451

GO term	Name	Ontology	Evidence	Reference
GO:0006886	intracellular protein transport	Biological Process	IEA	GO_REF:0000120
GO:0006914	autophagy	Biological Process	IEA	GO_REF:0000120
GO:0015031	protein transport	Biological Process	IEA	GO_REF:0000043
GO:0016192	vesicle-mediated transport	Biological Process	IEA	GO_REF:0000120
GO:0006904	vesicle docking involved in exocytosis	Biological Process	IBA	GO_REF:0000033
GO:0007032	endosome organization	Biological Process	IBA	GO_REF:0000033
GO:0007033	vacuole organization	Biological Process	IBA	GO_REF:0000033
GO:0008333	endosome to lysosome transport	Biological Process	IMP	PMID:25783203
GO:0016567	protein ubiquitination	Biological Process	IMP	PMID:31015428
GO:0031647	regulation of protein stability	Biological Process	HMP	PMID:24270810
GO:0033147	negative regulation of intracellular estrogen receptor signaling pathway	Biological Process	IGI	PMID:31015428
GO:0034058	endosomal vesicle fusion	Biological Process	IMP	PMID:21148287
GO:0035542	regulation of SNARE complex assembly	Biological Process	NAS	PMID:24554770
GO:0045732	positive regulation of protein catabolic process	Biological Process	IMP	PMID:21148287
GO:0048284	organelle fusion	Biological Process	IBA	GO_REF:0000033
GO:1902115	regulation of organelle assembly	Biological Process	IMP	PMID:21148287
GO:1903955	positive regulation of protein targeting to mitochondrion	Biological Process	HMP	PMID:24270810
GO:2000643	positive regulation of early endosome to late endosome transport	Biological Process	IMP	PMID:21148287
GO:0030123	AP-3 adaptor complex	Cellular Component	IEA	GO_REF:0000107
GO:0048786	presynaptic active zone	Cellular Component	IEA	GO_REF:0000107
GO:0005764	lysosome	Cellular Component	IEA	GO_REF:0000043
GO:0005765	lysosomal membrane	Cellular Component	IEA	GO_REF:0000120
GO:0005768	endosome	Cellular Component	IEA	GO_REF:0000120
GO:0005769	early endosome	Cellular Component	IEA	GO_REF:0000120
GO:0005776	autophagosome	Cellular Component	IEA	GO_REF:0000120
GO:0005884	actin filament	Cellular Component	IEA	GO_REF:0000107
GO:0016020	membrane	Cellular Component	IEA	GO_REF:0000043
GO:0030136	clathrin-coated vesicle	Cellular Component	IEA	GO_REF:0000120
GO:0031410	cytoplasmic vesicle	Cellular Component	IEA	GO_REF:0000043
GO:0031902	late endosome membrane	Cellular Component	IEA	GO_REF:0000120
GO:0030897	HOPS complex	Cellular Component	IEA	GO_REF:0000104
GO:0033263	CORVET complex	Cellular Component	IEA	GO_REF:0000120
GO:0099023	vesicle tethering complex	Cellular Component	IEA	GO_REF:0000117
GO:0012505	endomembrane system	Cellular Component	IEA	GO_REF:0000117
GO:0005770	late endosome	Cellular Component	IDA	PMID:21148287
GO:0010008	endosome membrane	Cellular Component	TAS	Reactome:R-HSA-9754537
GO:0030139	endocytic vesicle	Cellular Component	IDA	PMID:20682791
GO:0000166	nucleotide binding	Molecular Function	IEA	GO_REF:0000043
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0005515	protein binding	Molecular Function	IPI	PMID:11382755
GO:0019904	protein domain specific binding	Molecular Function	IPI	PMID:21148287
GO:0019905	syntaxin binding	Molecular Function	IDA	PMID:11382755
GO:0030674	protein-macromolecule adaptor activity	Molecular Function	IBA	GO_REF:0000033
GO:0061630	ubiquitin protein ligase activity	Molecular Function	IMP	PMID:31015428

Substrate	Name	Known ESI (UbiBrowser)	Known ESI (UbiNet)	PPI (IntAct direct) PSI-MI score ≥ 0.5	PPI (IntAct indirect) PSI-MI scores ≥ 0.5 for both PPIs	PubMed Ref.	IntAct Ref.	Substrate Specificity