GZF1

Details:

UniProt Entry: Q9H116
Gene: GZF1
Class: RING
Family: RING6
Protein length: 711
Database confidence: 0.25
InterPro: InterPro Entry
Mode of Action: Unclassified
AlphaFold Model: Link

Protein Sequence ▾

>Q9H116
MESGAVLLES KSSPFNLLHE MHELRLLGHL CDVTVSVEYQ GVRKDFMAHK AVLAATSKFF
KEVFLNEKSV DGTRTNVYLN EVQVADFASF LEFVYTAKVQ VEEDRVQRML EVAEKLKCLD
LSETCFQLKK QMLESVLLEL QNFSESQEVE VSSGSQVSAA PAPRASVATD GPHPSGLTDS
LDYPGERASN GMSSDLPPKK SKDKLDKKKE VVKPPYPKIR RASGRLAGRK VFVEIPKKKY
TRRLREQQKT AEGDVGDYRC PQDQSPDRVG TEMEQVSKNE GCQAGAELEE LSKKAGPEEE
EEEEEEDEEG EKKKSNFKCS ICEKAFLYEK SFLKHSKHRH GVATEVVYRC DTCGQTFANR
CNLKSHQRHV HSSERHFPCE LCGKKFKRKK DVKRHVLQVH EGGGERHRCG QCGKGLSSKT
ALRLHERTHT GDRPYGCTEC GARFSQPSAL KTHMRIHTGE KPFVCDECGA RFTQNHMLIY
HKRCHTGERP FMCETCGKSF ASKEYLKHHN RIHTGSKPFK CEVCFRTFAQ RNSLYQHIKV
HTGERPYCCD QCGKQFTQLN ALQRHRRIHT GERPFMCNAC GRTFTDKSTL RRHTSIHDKN
TPWKSFLVIV DGSPKNDDGH KTEQPDEEYV SSKLSDKLLS FAENGHFHNL AAVQDTVPTM
QENSSADTAC KADDSVVSQD TLLATTISEL SELTPQTDSM PTQLHSLSNM E

Domain Architecture (From InterPro) ▾

The same domains may appear in multiple rows, following InterPro convention.

Start	End	Type	Name	InterPro	Source
7	155	Homologous_superfamily	SKP1/BTB/POZ domain superfamily	IPR011333	G3DSA:3.30.710.10
9	127	Homologous_superfamily	SKP1/BTB/POZ domain superfamily	IPR011333	SSF54695
22	130	Domain	BTB/POZ domain	IPR000210	PF00651
31	103	Domain	BTB/POZ domain	IPR000210	PS50097
31	133	Domain	BTB/POZ domain	IPR000210	SM00225
317	340	Domain	Zinc finger C2H2-type	IPR013087	PS50157
317	340	Domain	Zinc finger C2H2-type	IPR013087	SM00355
347	396	Homologous_superfamily	Zinc finger C2H2 superfamily	IPR036236	SSF57667
348	371	Domain	Zinc finger C2H2-type	IPR013087	PF00096
348	376	Domain	Zinc finger C2H2-type	IPR013087	PS50157
348	371	Domain	Zinc finger C2H2-type	IPR013087	SM00355
350	371	Domain	Zinc finger C2H2-type	IPR013087	PS00028
377	400	Domain	Zinc finger C2H2-type	IPR013087	SM00355
377	405	Domain	Zinc finger C2H2-type	IPR013087	PS50157
379	400	Domain	Zinc finger C2H2-type	IPR013087	PS00028
406	457	Homologous_superfamily	Zinc finger C2H2 superfamily	IPR036236	SSF57667
407	429	Domain	Zinc finger C2H2-type	IPR013087	SM00355
407	434	Domain	Zinc finger C2H2-type	IPR013087	PS50157
409	429	Domain	Zinc finger C2H2-type	IPR013087	PS00028
435	457	Domain	Zinc finger C2H2-type	IPR013087	SM00355
435	462	Domain	Zinc finger C2H2-type	IPR013087	PS50157
437	457	Domain	Zinc finger C2H2-type	IPR013087	PS00028
437	457	Domain	Zinc finger C2H2-type	IPR013087	PF00096
444	500	Homologous_superfamily	Zinc finger C2H2 superfamily	IPR036236	SSF57667
463	490	Domain	Zinc finger C2H2-type	IPR013087	PS50157
463	485	Domain	Zinc finger C2H2-type	IPR013087	SM00355
465	485	Domain	Zinc finger C2H2-type	IPR013087	PS00028
491	518	Domain	Zinc finger C2H2-type	IPR013087	PS50157
491	513	Domain	Zinc finger C2H2-type	IPR013087	SM00355
491	513	Domain	Zinc finger C2H2-type	IPR013087	PF00096
493	513	Domain	Zinc finger C2H2-type	IPR013087	PS00028
499	556	Homologous_superfamily	Zinc finger C2H2 superfamily	IPR036236	SSF57667
519	541	Domain	Zinc finger C2H2-type	IPR013087	SM00355
519	546	Domain	Zinc finger C2H2-type	IPR013087	PS50157
519	541	Domain	Zinc finger C2H2-type	IPR013087	PF00096
521	541	Domain	Zinc finger C2H2-type	IPR013087	PS00028
541	593	Homologous_superfamily	Zinc finger C2H2 superfamily	IPR036236	SSF57667
547	569	Domain	Zinc finger C2H2-type	IPR013087	SM00355
547	574	Domain	Zinc finger C2H2-type	IPR013087	PS50157
547	569	Domain	Zinc finger C2H2-type	IPR013087	PF00096
548	569	Domain	Zinc finger C2H2-type	IPR013087	PS00028
575	597	Domain	Zinc finger C2H2-type	IPR013087	SM00355
575	597	Domain	Zinc finger C2H2-type	IPR013087	PF00096
575	602	Domain	Zinc finger C2H2-type	IPR013087	PS50157
577	597	Domain	Zinc finger C2H2-type	IPR013087	PS00028

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0000122	negative regulation of transcription by RNA polymerase II	Biological Process	IEA	GO_REF:0000120
GO:0001658	branching involved in ureteric bud morphogenesis	Biological Process	IEA	GO_REF:0000107
GO:0006355	regulation of DNA-templated transcription	Biological Process	IBA	GO_REF:0000033
GO:0045892	negative regulation of DNA-templated transcription	Biological Process	IDA	PMID:16049025
GO:0005634	nucleus	Cellular Component	IEA	GO_REF:0000120
GO:0005654	nucleoplasm	Cellular Component	IEA	GO_REF:0000044
GO:0005730	nucleolus	Cellular Component	IEA	GO_REF:0000044
GO:0005737	cytoplasm	Cellular Component	IEA	GO_REF:0000120
GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Molecular Function	IBA	GO_REF:0000033
GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	Molecular Function	IBA	GO_REF:0000033
GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	Molecular Function	IDA	PMID:16049025
GO:0003677	DNA binding	Molecular Function	IEA	GO_REF:0000043
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0043565	sequence-specific DNA binding	Molecular Function	IDA	PMID:16049025
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043

Enzyme–Substrate Interactions ▾

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