WWP1

Details:

UniProt Entry: Q9H0M0
Gene: WWP1
Class: HECT
Family: HECT1
Protein length: 922
Database confidence: 0.875
InterPro: InterPro Entry
Mode of Action: Standalone
AlphaFold Model: Link
PDB Structures: 1nd7, 2op7, 5hps, 5hpt, 6j1x, 6j1y

Protein Sequence ▾

>Q9H0M0
MATASPRSDT SNNHSGRLQL QVTVSSAKLK RKKNWFGTAI YTEVVVDGEI TKTAKSSSSS
NPKWDEQLTV NVTPQTTLEF QVWSHRTLKA DALLGKATID LKQALLIHNR KLERVKEQLK
LSLENKNGIA QTGELTVVLD GLVIEQENIT NCSSSPTIEI QENGDALHEN GEPSARTTAR
LAVEGTNGID NHVPTSTLVQ NSCCSYVVNG DNTPSSPSQV AARPKNTPAP KPLASEPADD
TVNGESSSFA PTDNASVTGT PVVSEENALS PNCTSTTVED PPVQEILTSS ENNECIPSTS
AELESEARSI LEPDTSNSRS SSAFEAAKSR QPDGCMDPVR QQSGNANTET LPSGWEQRKD
PHGRTYYVDH NTRTTTWERP QPLPPGWERR VDDRRRVYYV DHNTRTTTWQ RPTMESVRNF
EQWQSQRNQL QGAMQQFNQR YLYSASMLAA ENDPYGPLPP GWEKRVDSTD RVYFVNHNTK
TTQWEDPRTQ GLQNEEPLPE GWEIRYTREG VRYFVDHNTR TTTFKDPRNG KSSVTKGGPQ
IAYERGFRWK LAHFRYLCQS NALPSHVKIN VSRQTLFEDS FQQIMALKPY DLRRRLYVIF
RGEEGLDYGG LAREWFFLLS HEVLNPMYCL FEYAGKNNYC LQINPASTIN PDHLSYFCFI
GRFIAMALFH GKFIDTGFSL PFYKRMLSKK LTIKDLESID TEFYNSLIWI RDNNIEECGL
EMYFSVDMEI LGKVTSHDLK LGGSNILVTE ENKDEYIGLM TEWRFSRGVQ EQTKAFLDGF
NEVVPLQWLQ YFDEKELEVM LCGMQEVDLA DWQRNTVYRH YTRNSKQIIW FWQFVKETDN
EVRMRLLQFV TGTCRLPLGG FAELMGSNGP QKFCIEKVGK DTWLPRSHTC FNRLDLPPYK
SYEQLKEKLL FAIEETEGFG QE

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
1	116	Domain	C2 domain	IPR000008	PS50004
2	922	Family	E3 ubiquitin-protein ligase, SMURF1 type	IPR024928	PIRSF001569
16	155	Homologous_superfamily	C2 domain superfamily	IPR035892	G3DSA:2.60.40.150
17	139	Homologous_superfamily	C2 domain superfamily	IPR035892	SSF49562
19	113	Domain	C2 domain	IPR000008	SM00239
19	106	Domain	C2 domain	IPR000008	PF00168
342	380	Homologous_superfamily	WW domain superfamily	IPR036020	SSF51045
349	382	Domain	WW domain	IPR001202	PS50020
350	382	Domain	WW domain	IPR001202	SM00456
351	380	Domain	WW domain	IPR001202	PF00397
352	382	Domain	WW domain	IPR001202	cd00201
355	380	Domain	WW domain	IPR001202	PS01159
381	415	Homologous_superfamily	WW domain superfamily	IPR036020	SSF51045
381	414	Domain	WW domain	IPR001202	PS50020
383	412	Domain	WW domain	IPR001202	PF00397
383	414	Domain	WW domain	IPR001202	SM00456
387	412	Domain	WW domain	IPR001202	PS01159
449	491	Homologous_superfamily	WW domain superfamily	IPR036020	SSF51045
456	489	Domain	WW domain	IPR001202	PS50020
457	489	Domain	WW domain	IPR001202	SM00456
458	487	Domain	WW domain	IPR001202	PF00397
459	488	Domain	WW domain	IPR001202	cd00201
462	487	Domain	WW domain	IPR001202	PS01159
493	528	Homologous_superfamily	WW domain superfamily	IPR036020	SSF51045
496	529	Domain	WW domain	IPR001202	PS50020
497	529	Domain	WW domain	IPR001202	SM00456
498	527	Domain	WW domain	IPR001202	PF00397
499	528	Domain	WW domain	IPR001202	cd00201
502	527	Domain	WW domain	IPR001202	PS01159
547	916	Homologous_superfamily	HECT, E3 ligase catalytic domain	IPR035983	SSF56204
568	920	Domain	HECT domain	IPR000569	cd00078
586	922	Domain	HECT domain	IPR000569	SM00119
588	922	Domain	HECT domain	IPR000569	PS50237
618	920	Domain	HECT domain	IPR000569	PF00632

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0006511	ubiquitin-dependent protein catabolic process	Biological Process	IEA	GO_REF:0000002
GO:0007165	signal transduction	Biological Process	NAS	PMID:9169421
GO:0007417	central nervous system development	Biological Process	NAS	PMID:9647693
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000120
GO:0034220	monoatomic ion transmembrane transport	Biological Process	TAS	Reactome:R-HSA-983712
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	Biological Process	IBA	GO_REF:0000033
GO:0045892	negative regulation of DNA-templated transcription	Biological Process	ISS	GO_REF:0000024
GO:0046718	symbiont entry into host cell	Biological Process	IEA	GO_REF:0000117
GO:0005737	cytoplasm	Cellular Component	IEA	GO_REF:0000117
GO:0005634	nucleus	Cellular Component	IEA	GO_REF:0000120
GO:0005829	cytosol	Cellular Component	IEA	GO_REF:0000117
GO:0005886	plasma membrane	Cellular Component	IEA	GO_REF:0000120
GO:0016020	membrane	Cellular Component	IEA	GO_REF:0000043
GO:0070062	extracellular exosome	Cellular Component	HDA	PMID:23533145
GO:0070161	anchoring junction	Cellular Component	IEA	GO_REF:0000120
GO:0000151	ubiquitin ligase complex	Cellular Component	NAS	PMID:9169421
GO:0004842	ubiquitin-protein transferase activity	Molecular Function	IEA	GO_REF:0000002
GO:0061630	ubiquitin protein ligase activity	Molecular Function	IEA	GO_REF:0000117
GO:0005515	protein binding	Molecular Function	IPI	PMID:16189514
GO:0016740	transferase activity	Molecular Function	IEA	GO_REF:0000043

Enzyme–Substrate Interactions ▾

Substrate	Name	Known ESI (UbiBrowser)	Known ESI (UbiNet)	PPI (IntAct direct) PSI-MI score ≥ 0.5	PPI (IntAct indirect) PSI-MI scores ≥ 0.5 for both PPIs	PubMed Ref.	IntAct Ref.	Substrate Specificity
O14681	EI24	Yes	No	No	No	—	No	E3-specific
O43541	SMAD6	Yes	Yes	No	No	—	No	Cluster-specific
Q9Y2J4	AMOL2	Yes	No	No	No	—	No	E3-specific
Q8N0X7	SPART	Yes	Yes	No	No	19765186, 28514442	EBI-2643801	Cluster-specific
Q9H0M0	WWP1	Yes	Yes	No	No	—	No	E3-specific
P15941	MUC1	Yes	No	No	No	—	No	E3-specific
O95835	LATS1	Yes	Yes	No	No	—	No	Cluster-specific
Q9Y5W3	KLF2	Yes	Yes	No	No	—	No	Cluster-specific

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