KLH25

Details:

UniProt Entry: Q9H0H3
Gene: KLHL25
Class: Other E3 Components
Family: Adaptor
Protein length: 589
Database confidence: 0.625
InterPro: InterPro Entry
Mode of Action: unknown
AlphaFold Model: Link

Protein Sequence ▾

>Q9H0H3
MSVSVHETRK SRSSTGSMNV TLFHKASHPD CVLAHLNTLR KHCMFTDVTL WAGDRAFPCH
RAVLAASSRY FEAMFSHGLR ESRDDTVNFQ DNLHPEVLEL LLDFAYSSRI AINEENAESL
LEAGDMLQFH DVRDAAAEFL EKNLFPSNCL GMMLLSDAHQ CRRLYEFSWR MCLVHFETVR
QSEDFNSLSK DTLLDLISSD ELETEDERVV FEAILQWVKH DLEPRKVHLP ELLRSVRLAL
LPSDCLQEAV SSEALLMADE RTKLIMDEAL RCKTRILQND GVVTSPCARP RKAGHTLLIL
GGQTFMCDKI YQVDHKAKEI IPKADLPSPR KEFSASAIGC KVYVTGGRGS ENGVSKDVWV
YDTVHEEWSK AAPMLIARFG HGSAELENCL YVVGGHTSLA GVFPASPSVS LKQVEKYDPG
ANKWMMVAPL RDGVSNAAVV SAKLKLFVFG GTSIHRDMVS KVQCYDPSEN RWTIKAECPQ
PWRYTAAAVL GSQIFIMGGD TEFTAASAYR FDCETNQWTR IGDMTAKRMS CHALASGNKL
YVVGGYFGTQ RCKTLDCYDP TSDTWNCITT VPYSLIPTAF VSTWKHLPA

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
1	589	Family	BTB-kelch protein	IPR017096	PIRSF037037
16	145	Homologous_superfamily	SKP1/BTB/POZ domain superfamily	IPR011333	G3DSA:3.30.710.10
23	142	Homologous_superfamily	SKP1/BTB/POZ domain superfamily	IPR011333	SSF54695
36	143	Domain	BTB/POZ domain	IPR000210	PF00651
46	114	Domain	BTB/POZ domain	IPR000210	PS50097
46	144	Domain	BTB/POZ domain	IPR000210	SM00225
149	251	Domain	BTB/Kelch-associated	IPR011705	SM00875
149	250	Domain	BTB/Kelch-associated	IPR011705	PF07707
279	503	Homologous_superfamily	Kelch-type beta propeller	IPR015915	G3DSA:2.120.10.80
296	340	Repeat	Kelch repeat type 1	IPR006652	SM00612
306	575	Homologous_superfamily	Kelch-type beta propeller	IPR015915	SSF117281
329	374	Repeat	Kelch repeat type 1	IPR006652	PF01344
341	388	Repeat	Kelch repeat type 1	IPR006652	SM00612
377	431	Repeat	Kelch repeat type 1	IPR006652	PF01344
389	444	Repeat	Kelch repeat type 1	IPR006652	SM00612
445	492	Repeat	Kelch repeat type 1	IPR006652	SM00612
483	524	Repeat	Kelch repeat type 1	IPR006652	PF01344
493	538	Repeat	Kelch repeat type 1	IPR006652	SM00612
504	586	Homologous_superfamily	Kelch-type beta propeller	IPR015915	G3DSA:2.120.10.80
530	570	Repeat	Kelch repeat type 1	IPR006652	PF01344
539	585	Repeat	Kelch repeat type 1	IPR006652	SM00612

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0006633	fatty acid biosynthetic process	Biological Process	IDA	PMID:19286649
GO:0006417	regulation of translation	Biological Process	IEA	GO_REF:0000043
GO:0006446	regulation of translational initiation	Biological Process	IDA	PMID:22578813
GO:0006511	ubiquitin-dependent protein catabolic process	Biological Process	IEA	GO_REF:0000107
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000041
GO:0032831	positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation	Biological Process	IEA	GO_REF:0000107
GO:0045717	negative regulation of fatty acid biosynthetic process	Biological Process	IDA	PMID:27664236
GO:0046321	positive regulation of fatty acid oxidation	Biological Process	ISS	GO_REF:0000024
GO:0051603	proteolysis involved in protein catabolic process	Biological Process	IEA	GO_REF:0000117
GO:0080090	regulation of primary metabolic process	Biological Process	IEA	GO_REF:0000117
GO:0005737	cytoplasm	Cellular Component	IDA	GO_REF:0000054
GO:0005829	cytosol	Cellular Component	TAS	Reactome:R-HSA-8952630
GO:0031463	Cul3-RING ubiquitin ligase complex	Cellular Component	IEA	GO_REF:0000120
GO:0005515	protein binding	Molecular Function	IPI	PMID:33961781
GO:1990756	ubiquitin-like ligase-substrate adaptor activity	Molecular Function	IEA	GO_REF:0000107

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