MKRN2

Details:

UniProt Entry: Q9H000
Gene: MKRN2
Class: RING
Family: RING1
Protein length: 416
Database confidence: 0.75
InterPro: InterPro Entry
Mode of Action: Standalone
AlphaFold Model: Link

Protein Sequence ▾

>Q9H000
MSTKQITCRY FMHGVCREGS QCLFSHDLAN SKPSTICKYY QKGYCAYGTR CRYDHTRPSA
AAGGAVGTMA HSVPSPAFHS PHPPSEVTAS IVKTNSHEPG KREKRTLVLR DRNLSGMAER
KTQPSMVSNP GSCSDPQPSP EMKPHSYLDA IRSGLDDVEA SSSYSNEQQL CPYAAAGECR
FGDACVYLHG EVCEICRLQV LHPFDPEQRK AHEKICMLTF EHEMEKAFAF QASQDKVCSI
CMEVILEKAS ASERRFGILS NCNHTYCLSC IRQWRCAKQF ENPIIKSCPE CRVISEFVIP
SVYWVEDQNK KNELIEAFKQ GMGKKACKYF EQGKGTCPFG SKCLYRHAYP DGRLAEPEKP
RKQLSSQGTV RFFNSVRLWD FIENRESRHV PNNEDVDMTE LGDLFMHLSG VESSEP

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
1	409	Family	MKRN-like	IPR045072	PTHR11224
2	28	Domain	Zinc finger, CCCH-type	IPR000571	SM00356
2	29	Domain	Zinc finger, CCCH-type	IPR000571	PS50103
3	27	Homologous_superfamily	Zinc finger, CCCH-type superfamily	IPR036855	SSF90229
7	27	Domain	E3 ligase, CCCH-type zinc finger	IPR041367	PF18044
31	58	Domain	Zinc finger, CCCH-type	IPR000571	PS50103
32	56	Homologous_superfamily	Zinc finger, CCCH-type superfamily	IPR036855	SSF90229
32	57	Domain	Zinc finger, CCCH-type	IPR000571	SM00356
36	55	Domain	Zinc finger, CCCH-type	IPR000571	PF00642
165	192	Domain	Zinc finger, CCCH-type	IPR000571	PS50103
166	191	Domain	Zinc finger, CCCH-type	IPR000571	SM00356
169	191	Domain	Zinc finger, CCCH-type	IPR000571	PF00642
217	324	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
238	292	Domain	Zinc finger, RING-type	IPR001841	PS50089
238	291	Domain	Zinc finger, RING-type	IPR001841	SM00184
238	291	Domain	Zinc finger, C3HC4 RING-type	IPR018957	PF00097
262	271	Conserved_site	Zinc finger, RING-type, conserved site	IPR017907	PS00518
321	350	Domain	Zinc finger, CCCH-type	IPR000571	PS50103
322	349	Domain	Zinc finger, CCCH-type	IPR000571	SM00356

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0000209	protein polyubiquitination	Biological Process	IEA	GO_REF:0000002
GO:0030154	cell differentiation	Biological Process	IEA	GO_REF:0000043
GO:0002862	negative regulation of inflammatory response to antigenic stimulus	Biological Process	ISS	GO_REF:0000024
GO:0006351	DNA-templated transcription	Biological Process	ISS	GO_REF:0000024
GO:0006511	ubiquitin-dependent protein catabolic process	Biological Process	ISS	GO_REF:0000024
GO:0007283	spermatogenesis	Biological Process	IEA	GO_REF:0000043
GO:0016567	protein ubiquitination	Biological Process	IBA	GO_REF:0000033
GO:0043491	phosphatidylinositol 3-kinase/protein kinase B signal transduction	Biological Process	ISS	GO_REF:0000024
GO:0045944	positive regulation of transcription by RNA polymerase II	Biological Process	ISS	GO_REF:0000024
GO:1901223	negative regulation of non-canonical NF-kappaB signal transduction	Biological Process	ISS	GO_REF:0000024
GO:0005634	nucleus	Cellular Component	IEA	GO_REF:0000120
GO:0005737	cytoplasm	Cellular Component	IEA	GO_REF:0000044
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000120
GO:0061630	ubiquitin protein ligase activity	Molecular Function	IEA	GO_REF:0000002
GO:0016740	transferase activity	Molecular Function	IEA	GO_REF:0000043
GO:0003723	RNA binding	Molecular Function	HDA	PMID:22681889
GO:0005515	protein binding	Molecular Function	IPI	PMID:17500595

Enzyme–Substrate Interactions ▾


O00425	IF2B3	Yes	No	No	No	—	No	E3-specific

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