KLHL4

Details:

UniProt Entry: Q9C0H6
Gene: KLHL4
Class: Other E3 Components
Family: Adaptor
Protein length: 718
Database confidence: 0.375
InterPro: InterPro Entry
Mode of Action: unknown
AlphaFold Model: Link

Protein Sequence ▾

>Q9C0H6
MSVSGKKEFD VKQILRLRWR WFSHPFQGST NTGSCLQQEG YEHRGTPVQG RLKSHSRDRN
GLKKSNSPVH HNILAPVPGP APAHQRAVQN LQQHNLIVHF QANEDTPKSV PEKNLFKEAC
EKRAQDLEMM ADDNIEDSTA RLDTQHSEDM NATRSEEQFH VINHAEQTLR KMENYLKEKQ
LCDVLLIAGH LRIPAHRLVL SAVSDYFAAM FTNDVLEAKQ EEVRMEGVDP NALNSLVQYA
YTGVLQLKED TIESLLAAAC LLQLTQVIDV CSNFLIKQLH PSNCLGIRSF GDAQGCTELL
NVAHKYTMEH FIEVIKNQEF LLLPANEISK LLCSDDINVP DEETIFHALM QWVGHDVQNR
QGELGMLLSY IRLPLLPPQL LADLETSSMF TGDLECQKLL MEAMKYHLLP ERRSMMQSPR
TKPRKSTVGA LYAVGGMDAM KGTTTIEKYD LRTNSWLHIG TMNGRRLQFG VAVIDNKLYV
VGGRDGLKTL NTVECFNPVG KIWTVMPPMS THRHGLGVAT LEGPMYAVGG HDGWSYLNTV
ERWDPEGRQW NYVASMSTPR STVGVVALNN KLYAIGGRDG SSCLKSMEYF DPHTNKWSLC
APMSKRRGGV GVATYNGFLY VVGGHDAPAS NHCSRLSDCV ERYDPKGDSW STVAPLSVPR
DAVAVCPLGD KLYVVGGYDG HTYLNTVESY DAQRNEWKEE VPVNIGRAGA CVVVVKLP

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
149	280	Homologous_superfamily	SKP1/BTB/POZ domain superfamily	IPR011333	G3DSA:3.30.710.10
160	277	Homologous_superfamily	SKP1/BTB/POZ domain superfamily	IPR011333	SSF54695
173	278	Domain	BTB/POZ domain	IPR000210	PF00651
182	249	Domain	BTB/POZ domain	IPR000210	PS50097
182	279	Domain	BTB/POZ domain	IPR000210	SM00225
284	385	Domain	BTB/Kelch-associated	IPR011705	SM00875
284	383	Domain	BTB/Kelch-associated	IPR011705	PF07707
404	567	Homologous_superfamily	Kelch-type beta propeller	IPR015915	G3DSA:2.120.10.80
429	463	Repeat	Kelch repeat type 1	IPR006652	PF01344
430	476	Repeat	Kelch repeat type 1	IPR006652	SM00612
430	628	Homologous_superfamily	Kelch-type beta propeller	IPR015915	SSF117281
465	510	Repeat	Kelch repeat type 1	IPR006652	PF01344
477	523	Repeat	Kelch repeat type 1	IPR006652	SM00612
513	557	Repeat	Kelch repeat type 1	IPR006652	PF01344
524	570	Repeat	Kelch repeat type 1	IPR006652	SM00612
559	604	Repeat	Kelch repeat type 1	IPR006652	PF01344
568	716	Homologous_superfamily	Kelch-type beta propeller	IPR015915	G3DSA:2.120.10.80
571	617	Repeat	Kelch repeat type 1	IPR006652	SM00612
606	657	Repeat	Kelch repeat type 1	IPR006652	PF01344
618	670	Repeat	Kelch repeat type 1	IPR006652	SM00612
635	715	Homologous_superfamily	Kelch-type beta propeller	IPR015915	SSF117281
662	699	Repeat	Kelch repeat type 1	IPR006652	PF01344
671	717	Repeat	Kelch repeat type 1	IPR006652	SM00612

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	Biological Process	IBA	GO_REF:0000033
GO:0005856	cytoskeleton	Cellular Component	IEA	GO_REF:0000120
GO:0005929	cilium	Cellular Component	IDA	GO_REF:0000052
GO:0015630	microtubule cytoskeleton	Cellular Component	IDA	GO_REF:0000052
GO:0034451	centriolar satellite	Cellular Component	IDA	GO_REF:0000052
GO:0036064	ciliary basal body	Cellular Component	IDA	GO_REF:0000052
GO:0005737	cytoplasm	Cellular Component	IBA	GO_REF:0000033
GO:0031463	Cul3-RING ubiquitin ligase complex	Cellular Component	IBA	GO_REF:0000033
GO:0003779	actin binding	Molecular Function	IEA	GO_REF:0000043
GO:1990756	ubiquitin-like ligase-substrate adaptor activity	Molecular Function	IBA	GO_REF:0000033

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