UBE2O

Details:

UniProt Entry: Q9C0C9
Gene: UBE2O
Class: Other E3 Components
Family: E2
Protein length: 1292
Database confidence: 0.125
InterPro: InterPro Entry
Mode of Action: unknown
AlphaFold Model: Link

Protein Sequence ▾

>Q9C0C9
MADPAAPTPA APAPAQAPAP APEAVPAPAA APVPAPAPAS DSASGPSSDS GPEAGSQRLL
FSHDLVSGRY RGSVHFGLVR LIHGEDSDSE GEEEGRGSSG CSEAGGAGHE EGRASPLRRG
YVRVQWYPEG VKQHVKETKL KLEDRSVVPR DVVRHMRSTD SQCGTVIDVN IDCAVKLIGT
NCIIYPVNSK DLQHIWPFMY GDYIAYDCWL GKVYDLKNQI ILKLSNGARC SMNTEDGAKL
YDVCPHVSDS GLFFDDSYGF YPGQVLIGPA KIFSSVQWLS GVKPVLSTKS KFRVVVEEVQ
VVELKVTWIT KSFCPGGTDS VSPPPSVITQ ENLGRVKRLG CFDHAQRQLG ERCLYVFPAK
VEPAKIAWEC PEKNCAQGEG SMAKKVKRLL KKQVVRIMSC SPDTQCSRDH SMEDPDKKGE
SKTKSEAESA SPEETPDGSA SPVEMQDEGA EEPHEAGEQL PPFLLKEGRD DRLHSAEQDA
DDEAADDTDD TSSVTSSASS TTSSQSGSGT SRKKSIPLSI KNLKRKHKRK KNKITRDFKP
GDRVAVEVVT TMTSADVMWQ DGSVECNIRS NDLFPVHHLD NNEFCPGDFV VDKRVQSCPD
PAVYGVVQSG DHIGRTCMVK WFKLRPSGDD VELIGEEEDV SVYDIADHPD FRFRTTDIVI
RIGNTEDGAP HKEDEPSVGQ VARVDVSSKV EVVWADNSKT IILPQHLYNI ESEIEESDYD
SVEGSTSGAS SDEWEDDSDS WETDNGLVED EHPKIEEPPI PPLEQPVAPE DKGVVISEEA
ATAAVQGAVA MAAPMAGLME KAGKDGPPKS FRELKEAIKI LESLKNMTVE QLLTGSPTSP
TVEPEKPTRE KKFLDDIKKL QENLKKTLDN VAIVEEEKME AVPDVERKED KPEGQSPVKA
EWPSETPVLC QQCGGKPGVT FTSAKGEVFS VLEFAPSNHS FKKIEFQPPE AKKFFSTVRK
EMALLATSLP EGIMVKTFED RMDLFSALIK GPTRTPYEDG LYLFDIQLPN IYPAVPPHFC
YLSQCSGRLN PNLYDNGKVC VSLLGTWIGK GTERWTSKSS LLQVLISIQG LILVNEPYYN
EAGFDSDRGL QEGYENSRCY NEMALIRVVQ SMTQLVRRPP EVFEQEIRQH FSTGGWRLVN
RIESWLETHA LLEKAQALPN GVPKASSSPE PPAVAELSDS GQQEPEDGGP APGEASQGSD
SEGGAQGLAS ASRDHTDQTS ETAPDASVPP SVKPKKRRKS YRSFLPEKSG YPDIGFPLFP
LSKGFIKSIR GVLTQFRAAL LEAGMPECTE DK

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
922	1168	Homologous_superfamily	Ubiquitin-conjugating enzyme/RWD-like	IPR016135	G3DSA:3.10.110.10
953	1113	Domain	Ubiquitin-conjugating enzyme E2	IPR000608	PS50127
956	1120	Homologous_superfamily	Ubiquitin-conjugating enzyme/RWD-like	IPR016135	SSF54495
958	1103	Domain	Ubiquitin-conjugating enzyme E2	IPR000608	PF00179
958	1108	Domain	Ubiquitin-conjugating enzyme E2	IPR000608	cd00195

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0006513	protein monoubiquitination	Biological Process	IDA	PMID:23455153
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000041
GO:0030513	positive regulation of BMP signaling pathway	Biological Process	IDA	PMID:23455153
GO:0042147	retrograde transport, endosome to Golgi	Biological Process	IBA	GO_REF:0000033
GO:0070534	protein K63-linked ubiquitination	Biological Process	IMP	PMID:23452853
GO:0005634	nucleus	Cellular Component	IEA	GO_REF:0000120
GO:0005737	cytoplasm	Cellular Component	IEA	GO_REF:0000120
GO:0005654	nucleoplasm	Cellular Component	IDA	GO_REF:0000052
GO:0005829	cytosol	Cellular Component	IEA	GO_REF:0000108
GO:0016604	nuclear body	Cellular Component	IDA	GO_REF:0000052
GO:0000166	nucleotide binding	Molecular Function	IEA	GO_REF:0000043
GO:0005524	ATP binding	Molecular Function	IEA	GO_REF:0000043
GO:0016740	transferase activity	Molecular Function	IEA	GO_REF:0000043
GO:0003723	RNA binding	Molecular Function	HDA	PMID:22681889
GO:0004842	ubiquitin-protein transferase activity	Molecular Function	IDA	PMID:23455153
GO:0005515	protein binding	Molecular Function	IPI	PMID:19549727
GO:0061630	ubiquitin protein ligase activity	Molecular Function	IDA	PMID:23455153
GO:0061631	ubiquitin conjugating enzyme activity	Molecular Function	IBA	GO_REF:0000033

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