TRIM2

Details:

UniProt Entry: Q9C040
Gene: TRIM2
Class: RING
Family: RING8
Protein length: 744
Database confidence: 0.875
InterPro: InterPro Entry
Mode of Action: Complex
AlphaFold Model: Link
PDB Structures: 7b2r, 7b96, 7qrv, 7zj3

Protein Sequence ▾

>Q9C040
MASEGTNIPS PVVRQIDKQF LICSICLERY KNPKVLPCLH TFCERCLQNY IPAHSLTLSC
PVCRQTSILP EKGVAALQNN FFITNLMDVL QRTPGSNAEE SSILETVTAV AAGKPLSCPN
HDGNVMEFYC QSCETAMCRE CTEGEHAEHP TVPLKDVVEQ HKASLQVQLD AVNKRLPEID
SALQFISEII HQLTNQKASI VDDIHSTFDE LQKTLNVRKS VLLMELEVNY GLKHKVLQSQ
LDTLLQGQES IKSCSNFTAQ ALNHGTETEV LLVKKQMSEK LNELADQDFP LHPRENDQLD
FIVETEGLKK SIHNLGTILT TNAVASETVA TGEGLRQTII GQPMSVTITT KDKDGELCKT
GNAYLTAELS TPDGSVADGE ILDNKNGTYE FLYTVQKEGD FTLSLRLYDQ HIRGSPFKLK
VIRSADVSPT TEGVKRRVKS PGSGHVKQKA VKRPASMYST GKRKENPIED DLIFRVGTKG
RNKGEFTNLQ GVAASTNGKI LIADSNNQCV QIFSNDGQFK SRFGIRGRSP GQLQRPTGVA
VHPSGDIIIA DYDNKWVSIF SSDGKFKTKI GSGKLMGPKG VSVDRNGHII VVDNKACCVF
IFQPNGKIVT RFGSRGNGDR QFAGPHFAAV NSNNEIIITD FHNHSVKVFN QEGEFMLKFG
SNGEGNGQFN APTGVAVDSN GNIIVADWGN SRIQVFDGSG SFLSYINTSA DPLYGPQGLA
LTSDGHVVVA DSGNHCFKVY RYLQ

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
13	95	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
23	61	Domain	Zinc finger, RING-type, eukaryotic	IPR027370	PF13445
23	63	Domain	Zinc finger, RING-type	IPR001841	SM00184
23	64	Domain	Zinc finger, RING-type	IPR001841	PS50089
38	47	Conserved_site	Zinc finger, RING-type, conserved site	IPR017907	PS00518
113	154	Domain	B-box-type zinc finger	IPR000315	PS50119
113	154	Domain	B-box-type zinc finger	IPR000315	SM00336
117	154	Domain	B-box-type zinc finger	IPR000315	PF00643
161	287	Domain	B-box, C-terminal	IPR003649	SM00502
320	421	Repeat	Filamin/ABP280 repeat-like	IPR017868	PS50194
322	427	Homologous_superfamily	Immunoglobulin-like fold	IPR013783	G3DSA:2.60.40.10
324	424	Repeat	Filamin/ABP280 repeat	IPR001298	SM00557
324	418	Repeat	Filamin/ABP280 repeat-like	IPR017868	PF00630
333	429	Homologous_superfamily	Immunoglobulin E-set	IPR014756	SSF81296
464	659	Homologous_superfamily	Six-bladed beta-propeller, TolB-like	IPR011042	G3DSA:2.120.10.30
473	516	Repeat	NHL repeat	IPR001258	PS51125
486	513	Repeat	NHL repeat	IPR001258	PF01436
520	563	Repeat	NHL repeat	IPR001258	PS51125
533	560	Repeat	NHL repeat	IPR001258	PF01436
564	605	Repeat	NHL repeat	IPR001258	PS51125
576	602	Repeat	NHL repeat	IPR001258	PF01436
609	652	Repeat	NHL repeat	IPR001258	PS51125
622	649	Repeat	NHL repeat	IPR001258	PF01436
656	699	Repeat	NHL repeat	IPR001258	PS51125
660	743	Homologous_superfamily	Six-bladed beta-propeller, TolB-like	IPR011042	G3DSA:2.120.10.30
669	696	Repeat	NHL repeat	IPR001258	PF01436
700	743	Repeat	NHL repeat	IPR001258	PS51125
713	740	Repeat	NHL repeat	IPR001258	PF01436

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:1990830	cellular response to leukemia inhibitory factor	Biological Process	IEA	GO_REF:0000107
GO:0000209	protein polyubiquitination	Biological Process	IBA	GO_REF:0000033
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000041
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	Biological Process	IBA	GO_REF:0000033
GO:0043523	regulation of neuron apoptotic process	Biological Process	ISS	GO_REF:0000024
GO:0005737	cytoplasm	Cellular Component	IEA	GO_REF:0000120
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0016740	transferase activity	Molecular Function	IEA	GO_REF:0000043
GO:0004842	ubiquitin-protein transferase activity	Molecular Function	ISS	GO_REF:0000024
GO:0005515	protein binding	Molecular Function	IPI	PMID:21478148
GO:0061630	ubiquitin protein ligase activity	Molecular Function	IBA	GO_REF:0000033

Enzyme–Substrate Interactions ▾


P07196	NFL	Yes	Yes	No	No	—	No	E3-specific

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