TRIM4

Details:

UniProt Entry: Q9C037
Gene: TRIM4
Class: RING
Family: RING5
Protein length: 500
Database confidence: 0.75
InterPro: InterPro Entry
Mode of Action: Standalone
AlphaFold Model: Link

Protein Sequence ▾

>Q9C037
MEAEDIQEEL TCPICLDYFQ DPVSIECGHN FCRGCLHRNW APGGGPFPCP ECRHPSAPAA
LRPNWALARL TEKTQRRRLG PVPPGLCGRH WEPLRLFCED DQRPVCLVCR ESQEHQTHAM
APIDEAFESY RTGNFDIHVD EWKRRLIRLL LYHFKQEEKL LKSQRNLVAK MKKVMHLQDV
EVKNATQWKD KIKSQRMRIS TEFSKLHNFL VEEEDLFLQR LNKEEEETKK KLNENTLKLN
QTIASLKKLI LEVGEKSQAP TLELLQNPKE VLTRSEIQDV NYSLEAVKVK TVCQIPLMKE
MLKRFQVAVN LAEDTAHPKL VFSQEGRYVK NTASASSWPV FSSAWNYFAG WRNPQKTAFV
ERFQHLPCVL GKNVFTSGKH YWEVESRDSL EVAVGVCRED VMGITDRSKM SPDVGIWAIY
WSAAGYWPLI GFPGTPTQQE PALHRVGVYL DRGTGNVSFY SAVDGVHLHT FSCSSVSRLR
PFFWLSPLAS LVIPPVTDRK

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
2	75	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
12	52	Domain	Zinc finger, RING-type	IPR001841	SM00184
12	53	Domain	Zinc finger, RING-type	IPR001841	PS50089
27	36	Conserved_site	Zinc finger, RING-type, conserved site	IPR017907	PS00518
82	123	Domain	B-box-type zinc finger	IPR000315	SM00336
82	123	Domain	B-box-type zinc finger	IPR000315	PS50119
85	123	Domain	B-box-type zinc finger	IPR000315	PF00643
288	500	Domain	B30.2/SPRY domain	IPR001870	PS50188
298	495	Homologous_superfamily	Concanavalin A-like lectin/glucanase domain superfamily	IPR013320	SSF49899
300	499	Homologous_superfamily	B30.2/SPRY domain superfamily	IPR043136	G3DSA:2.60.120.920
305	322	Domain	Butyrophylin-like, SPRY domain	IPR003879	PR01407
305	494	Domain	TRIM4, PRY/SPRY domain	IPR035829	cd15809
377	497	Domain	SPRY domain	IPR003877	SM00449
379	492	Domain	SPRY domain	IPR003877	PF00622
392	405	Domain	Butyrophylin-like, SPRY domain	IPR003879	PR01407
437	461	Domain	Butyrophylin-like, SPRY domain	IPR003879	PR01407
467	485	Domain	Butyrophylin-like, SPRY domain	IPR003879	PR01407

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0002376	immune system process	Biological Process	IEA	GO_REF:0000043
GO:0010468	regulation of gene expression	Biological Process	IBA	GO_REF:0000033
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000041
GO:0045087	innate immune response	Biological Process	IBA	GO_REF:0000033
GO:0005829	cytosol	Cellular Component	IDA	GO_REF:0000052
GO:0005886	plasma membrane	Cellular Component	IDA	GO_REF:0000052
GO:0005737	cytoplasm	Cellular Component	IBA	GO_REF:0000033
GO:0004842	ubiquitin-protein transferase activity	Molecular Function	EXP	PMID:17392790
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000120
GO:0016740	transferase activity	Molecular Function	IEA	GO_REF:0000043
GO:0042802	identical protein binding	Molecular Function	IPI	PMID:17156811
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0061630	ubiquitin protein ligase activity	Molecular Function	IEA	GO_REF:0000003

Enzyme–Substrate Interactions ▾


Q7Z2W7	TRPM8	Yes	No	No	No	—	No	E3-specific

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