TRIM5

Details:

UniProt Entry: Q9C035
Gene: TRIM5
Class: RING
Family: RING5
Protein length: 493
Database confidence: 1.0
InterPro: InterPro Entry
Mode of Action: Standalone
AlphaFold Model: Link
PDB Structures: 2ecv, 2yrg

Protein Sequence ▾

>Q9C035
MASGILVNVK EEVTCPICLE LLTQPLSLDC GHSFCQACLT ANHKKSMLDK GESSCPVCRI
SYQPENIRPN RHVANIVEKL REVKLSPEGQ KVDHCARHGE KLLLFCQEDG KVICWLCERS
QEHRGHHTFL TEEVAREYQV KLQAALEMLR QKQQEAEELE ADIREEKASW KTQIQYDKTN
VLADFEQLRD ILDWEESNEL QNLEKEEEDI LKSLTNSETE MVQQTQSLRE LISDLEHRLQ
GSVMELLQGV DGVIKRTENV TLKKPETFPK NQRRVFRAPD LKGMLEVFRE LTDVRRYWVD
VTVAPNNISC AVISEDKRQV SSPKPQIIYG ARGTRYQTFV NFNYCTGILG SQSITSGKHY
WEVDVSKKTA WILGVCAGFQ PDAMCNIEKN ENYQPKYGYW VIGLEEGVKC SAFQDSSFHT
PSVPFIVPLS VIICPDRVGV FLDYEACTVS FFNITNHGFL IYKFSHCSFS QPVFPYLNPR
KCGVPMTLCS PSS

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
2	90	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
15	58	Domain	Zinc finger, RING-type	IPR001841	SM00184
15	59	Domain	Zinc finger, RING-type	IPR001841	PS50089
15	56	Domain	Zinc finger, RING-type, eukaryotic	IPR027370	PF13445
30	39	Conserved_site	Zinc finger, RING-type, conserved site	IPR017907	PS00518
90	131	Domain	B-box-type zinc finger	IPR000315	SM00336
90	132	Domain	B-box-type zinc finger	IPR000315	PS50119
91	128	Domain	B-box-type zinc finger	IPR000315	PF00643
281	493	Domain	B30.2/SPRY domain	IPR001870	PS50188
288	493	Homologous_superfamily	B30.2/SPRY domain superfamily	IPR043136	G3DSA:2.60.120.920
292	491	Homologous_superfamily	Concanavalin A-like lectin/glucanase domain superfamily	IPR013320	SSF49899
313	330	Domain	Butyrophylin-like, SPRY domain	IPR003879	PR01407
356	492	Domain	SPRY domain	IPR003877	SM00449
358	478	Domain	SPRY domain	IPR003877	PF00622
429	453	Domain	Butyrophylin-like, SPRY domain	IPR003879	PR01407
461	479	Domain	Butyrophylin-like, SPRY domain	IPR003879	PR01407

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0010468	regulation of gene expression	Biological Process	IEA	GO_REF:0000117
GO:0080090	regulation of primary metabolic process	Biological Process	IEA	GO_REF:0000117
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000117
GO:0002218	activation of innate immune response	Biological Process	IDA	PMID:21512573
GO:0002376	immune system process	Biological Process	IEA	GO_REF:0000043
GO:0006914	autophagy	Biological Process	IEA	GO_REF:0000043
GO:0031664	regulation of lipopolysaccharide-mediated signaling pathway	Biological Process	IMP	PMID:21512573
GO:0032880	regulation of protein localization	Biological Process	IBA	GO_REF:0000033
GO:0043123	positive regulation of canonical NF-kappaB signal transduction	Biological Process	IBA	GO_REF:0000033
GO:0043410	positive regulation of MAPK cascade	Biological Process	IMP	PMID:21512573
GO:0044790	suppression of viral release by host	Biological Process	IDA	PMID:18248090
GO:0045087	innate immune response	Biological Process	IBA	GO_REF:0000033
GO:0045893	positive regulation of DNA-templated transcription	Biological Process	IEA	GO_REF:0000108
GO:0046596	regulation of viral entry into host cell	Biological Process	IBA	GO_REF:0000033
GO:0046597	host-mediated suppression of symbiont invasion	Biological Process	IDA	PMID:18248090
GO:0051092	positive regulation of NF-kappaB transcription factor activity	Biological Process	IMP	PMID:21512573
GO:0051607	defense response to virus	Biological Process	IEA	GO_REF:0000043
GO:0070534	protein K63-linked ubiquitination	Biological Process	IDA	PMID:21512573
GO:0005737	cytoplasm	Cellular Component	IEA	GO_REF:0000044
GO:1990462	omegasome	Cellular Component	IDA	PMID:25127057
GO:0000932	P-body	Cellular Component	IDA	PMID:20357094
GO:0005634	nucleus	Cellular Component	IEA	GO_REF:0000120
GO:0005829	cytosol	Cellular Component	TAS	Reactome:R-HSA-1031716
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000120
GO:0016740	transferase activity	Molecular Function	IEA	GO_REF:0000043
GO:0042802	identical protein binding	Molecular Function	IEA	GO_REF:0000117
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0061630	ubiquitin protein ligase activity	Molecular Function	IEA	GO_REF:0000003
GO:0003713	transcription coactivator activity	Molecular Function	IDA	PMID:23077300
GO:0004842	ubiquitin-protein transferase activity	Molecular Function	IDA	PMID:21512573
GO:0005515	protein binding	Molecular Function	IPI	PMID:20357094
GO:0019901	protein kinase binding	Molecular Function	IBA	GO_REF:0000033
GO:0030674	protein-macromolecule adaptor activity	Molecular Function	IPI	PMID:25127057
GO:0038187	pattern recognition receptor activity	Molecular Function	IDA	PMID:21512573
GO:0042803	protein homodimerization activity	Molecular Function	IBA	GO_REF:0000033

Enzyme–Substrate Interactions ▾


Q9C035	TRIM5	Yes	Yes	Yes	No	22829933, 22493164	EBI-4307404	Cluster-specific

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