TRIM6

Details:

UniProt Entry: Q9C030
Gene: TRIM6
Class: RING
Family: RING5
Protein length: 488
Database confidence: 0.75
InterPro: InterPro Entry
Mode of Action: Standalone
AlphaFold Model: Link

Protein Sequence ▾

>Q9C030
MTSPVLVDIR EEVTCPICLE LLTEPLSIDC GHSFCQACIT PNGRESVIGQ EGERSCPVCQ
TSYQPGNLRP NRHLANIVRR LREVVLGPGK QLKAVLCADH GEKLQLFCQE DGKVICWLCE
RSQEHRGHHT FLVEEVAQEY QEKFQESLKK LKNEEQEAEK LTAFIREKKT SWKNQMEPER
CRIQTEFNQL RNILDRVEQR ELKKLEQEEK KGLRIIEEAE NDLVHQTQSL RELISDLERR
CQGSTMELLQ DVSDVTERSE FWTLRKPEAL PTKLRSMFRA PDLKRMLRVC RELTDVQSYW
VDVTLNPHTA NLNLVLAKNR RQVRFVGAKV SGPSCLEKHY DCSVLGSQHF SSGKHYWEVD
VAKKTAWILG VCSNSLGPTF SFNHFAQNHS AYSRYQPQSG YWVIGLQHNH EYRAYEDSSP
SLLLSMTVPP RRVGVFLDYE AGTVSFYNVT NHGFPIYTFS KYYFPTTLCP YFNPCNCVIP
MTLRRPSS

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
2	87	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
15	60	Domain	Zinc finger, RING-type	IPR001841	PS50089
15	59	Domain	Zinc finger, RING-type	IPR001841	SM00184
15	57	Domain	Zinc finger, RING-type, eukaryotic	IPR027370	PF13445
30	39	Conserved_site	Zinc finger, RING-type, conserved site	IPR017907	PS00518
92	133	Domain	B-box-type zinc finger	IPR000315	SM00336
92	133	Domain	B-box-type zinc finger	IPR000315	PS50119
95	130	Domain	B-box-type zinc finger	IPR000315	PF00643
282	488	Domain	B30.2/SPRY domain	IPR001870	PS50188
290	488	Homologous_superfamily	B30.2/SPRY domain superfamily	IPR043136	G3DSA:2.60.120.920
294	482	Homologous_superfamily	Concanavalin A-like lectin/glucanase domain superfamily	IPR013320	SSF49899
299	316	Domain	Butyrophylin-like, SPRY domain	IPR003879	PR01407
299	486	Domain	TRIM6, PRY/SPRY domain	IPR035828	cd15823
300	351	Domain	SPRY-associated	IPR006574	SM00589
337	361	Domain	Butyrophylin-like, SPRY domain	IPR003879	PR01407
352	487	Domain	SPRY domain	IPR003877	SM00449
354	472	Domain	SPRY domain	IPR003877	PF00622
424	448	Domain	Butyrophylin-like, SPRY domain	IPR003879	PR01407
456	474	Domain	Butyrophylin-like, SPRY domain	IPR003879	PR01407

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:1901222	regulation of non-canonical NF-kappaB signal transduction	Biological Process	IMP	PMID:24882218
GO:0060337	type I interferon-mediated signaling pathway	Biological Process	IDA	PMID:23386060
GO:0060340	positive regulation of type I interferon-mediated signaling pathway	Biological Process	IDA	PMID:24882218
GO:0140374	antiviral innate immune response	Biological Process	IDA	PMID:28469175
GO:0000209	protein polyubiquitination	Biological Process	IEA	GO_REF:0000107
GO:0002230	positive regulation of defense response to virus by host	Biological Process	IMP	PMID:24882218
GO:0002720	positive regulation of cytokine production involved in immune response	Biological Process	IMP	PMID:24882218
GO:0010468	regulation of gene expression	Biological Process	IBA	GO_REF:0000033
GO:0010628	positive regulation of gene expression	Biological Process	IEA	GO_REF:0000107
GO:0010629	negative regulation of gene expression	Biological Process	IMP	PMID:24882218
GO:0010800	positive regulation of peptidyl-threonine phosphorylation	Biological Process	IMP	PMID:24882218
GO:0010994	free ubiquitin chain polymerization	Biological Process	IMP	PMID:24882218
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000041
GO:0032496	response to lipopolysaccharide	Biological Process	IMP	PMID:24882218
GO:0033138	positive regulation of peptidyl-serine phosphorylation	Biological Process	IMP	PMID:24882218
GO:0035458	cellular response to interferon-beta	Biological Process	IMP	PMID:24882218
GO:0045071	negative regulation of viral genome replication	Biological Process	IEA	GO_REF:0000107
GO:0045087	innate immune response	Biological Process	IBA	GO_REF:0000033
GO:0045892	negative regulation of DNA-templated transcription	Biological Process	IEA	GO_REF:0000107
GO:0070936	protein K48-linked ubiquitination	Biological Process	IDA	PMID:24882218
GO:0080090	regulation of primary metabolic process	Biological Process	IEA	GO_REF:0000117
GO:0098586	cellular response to virus	Biological Process	IEA	GO_REF:0000107
GO:2000679	positive regulation of transcription regulatory region DNA binding	Biological Process	IMP	PMID:24882218
GO:2000737	negative regulation of stem cell differentiation	Biological Process	IEA	GO_REF:0000107
GO:0005737	cytoplasm	Cellular Component	IEA	GO_REF:0000044
GO:0005829	cytosol	Cellular Component	IBA	GO_REF:0000033
GO:0005634	nucleus	Cellular Component	IEA	GO_REF:0000107
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0016740	transferase activity	Molecular Function	IEA	GO_REF:0000043
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0061630	ubiquitin protein ligase activity	Molecular Function	IEA	GO_REF:0000003
GO:0005515	protein binding	Molecular Function	IPI	PMID:25127057
GO:0019901	protein kinase binding	Molecular Function	IBA	GO_REF:0000033
GO:0030674	protein-macromolecule adaptor activity	Molecular Function	IPI	PMID:25127057
GO:0042802	identical protein binding	Molecular Function	IEA	GO_REF:0000117
GO:0140297	DNA-binding transcription factor binding	Molecular Function	IEA	GO_REF:0000107
GO:1990782	protein tyrosine kinase binding	Molecular Function	IPI	PMID:24882218

Enzyme–Substrate Interactions ▾


P78543	BTG2	Yes	No	No	No	—	No	E3-specific

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