TRIM7

Details:

UniProt Entry: Q9C029
Gene: TRIM7
Class: RING
Family: RING5
Protein length: 511
Database confidence: 0.75
InterPro: InterPro Entry
Mode of Action: Complex
AlphaFold Model: Link
PDB Structures: 6uma, 6umb, 7ovx, 7ow2, 7w0q, 7w0s, 7w0t, 7x6y, 7x6z, 7x70, 7y3a, 7y3b, 7y3c, 8a5l, 8a5m, 8a8x

Protein Sequence ▾

>Q9C029
MAAVGPRTGP GTGAEALALA AELQGEATCS ICLELFREPV SVECGHSFCR ACIGRCWERP
GAGSVGAATR APPFPLPCPQ CREPARPSQL RPNRQLAAVA TLLRRFSLPA AAPGEHGSQA
AAARAAAARC GQHGEPFKLY CQDDGRAICV VCDRAREHRE HAVLPLDEAV QEAKELLESR
LRVLKKELED CEVFRSTEKK ESKELLKQMA AEQEKVGAEF QALRAFLVEQ EGRLLGRLEE
LSREVAQKQN ENLAQLGVEI TQLSKLSSQI QETAQKPDLD FLQEFKSTLS RCSNVPGPKP
TTVSSEMKNK VWNVSLKTFV LKGMLKKFKE DLRGELEKEE KVELTLDPDT ANPRLILSLD
LKGVRLGERA QDLPNHPCRF DTNTRVLASC GFSSGRHHWE VEVGSKDGWA FGVARESVRR
KGLTPFTPEE GVWALQLNGG QYWAVTSPER SPLSCGHLSR VRVALDLEVG AVSFYAVEDM
RHLYTFRVNF QERVFPLFSV CSTGTYLRIW P

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
12	109	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
29	81	Domain	Zinc finger, RING-type	IPR001841	SM00184
29	82	Domain	Zinc finger, RING-type	IPR001841	PS50089
44	53	Conserved_site	Zinc finger, RING-type, conserved site	IPR017907	PS00518
125	166	Domain	B-box-type zinc finger	IPR000315	PS50119
125	166	Domain	B-box-type zinc finger	IPR000315	SM00336
129	166	Domain	B-box-type zinc finger	IPR000315	PF00643
138	155	Domain	Zinc finger, B-box, chordata	IPR020457	PR01406
157	171	Domain	Zinc finger, B-box, chordata	IPR020457	PR01406
318	510	Homologous_superfamily	B30.2/SPRY domain superfamily	IPR043136	G3DSA:2.60.120.920
324	511	Domain	B30.2/SPRY domain	IPR001870	PS50188
340	508	Homologous_superfamily	Concanavalin A-like lectin/glucanase domain superfamily	IPR013320	SSF49899
340	357	Domain	Butyrophylin-like, SPRY domain	IPR003879	PR01407
341	393	Domain	SPRY-associated	IPR006574	SM00589
344	392	Domain	SPRY-associated	IPR006574	PF13765
357	374	Domain	Butyrophylin-like, SPRY domain	IPR003879	PR01407
379	403	Domain	Butyrophylin-like, SPRY domain	IPR003879	PR01407
394	507	Domain	SPRY domain	IPR003877	SM00449
396	501	Domain	SPRY domain	IPR003877	PF00622
409	422	Domain	Butyrophylin-like, SPRY domain	IPR003879	PR01407
452	476	Domain	Butyrophylin-like, SPRY domain	IPR003879	PR01407
482	500	Domain	Butyrophylin-like, SPRY domain	IPR003879	PR01407

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000041
GO:0045087	innate immune response	Biological Process	IBA	GO_REF:0000033
GO:0051607	defense response to virus	Biological Process	IEA	GO_REF:0000043
GO:0140374	antiviral innate immune response	Biological Process	IDA	PMID:35893676
GO:0005737	cytoplasm	Cellular Component	IBA	GO_REF:0000033
GO:0005634	nucleus	Cellular Component	IEA	GO_REF:0000120
GO:0005794	Golgi apparatus	Cellular Component	IEA	GO_REF:0000120
GO:0005515	protein binding	Molecular Function	IPI	PMID:25416956
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000120
GO:0016740	transferase activity	Molecular Function	IEA	GO_REF:0000043
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0061630	ubiquitin protein ligase activity	Molecular Function	IEA	GO_REF:0000003

Enzyme–Substrate Interactions ▾


Q9HCU9	BRMS1	Yes	No	No	No	—	No	E3-specific

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