TRIM9

Details:

UniProt Entry: Q9C026
Gene: TRIM9
Class: RING
Family: RING8
Protein length: 710
Database confidence: 0.875
InterPro: InterPro Entry
Mode of Action: Complex
AlphaFold Model: Link
PDB Structures: 2db8, 7b2s

Protein Sequence ▾

>Q9C026
MEEMEEELKC PVCGSFYREP IILPCSHNLC QACARNILVQ TPESESPQSH RAAGSGVSDY
DYLDLDKMSL YSEADSGYGS YGGFASAPTT PCQKSPNGVR VFPPAMPPPA THLSPALAPV
PRNSCITCPQ CHRSLILDDR GLRGFPKNRV LEGVIDRYQQ SKAAALKCQL CEKAPKEATV
MCEQCDVFYC DPCRLRCHPP RGPLAKHRLV PPAQGRVSRR LSPRKVSTCT DHELENHSMY
CVQCKMPVCY QCLEEGKHSS HEVKALGAMW KLHKSQLSQA LNGLSDRAKE AKEFLVQLRN
MVQQIQENSV EFEACLVAQC DALIDALNRR KAQLLARVNK EHEHKLKVVR DQISHCTVKL
RQTTGLMEYC LEVIKENDPS GFLQISDALI RRVHLTEDQW GKGTLTPRMT TDFDLSLDNS
PLLQSIHQLD FVQVKASSPV PATPILQLEE CCTHNNSATL SWKQPPLSTV PADGYILELD
DGNGGQFREV YVGKETMCTV DGLHFNSTYN ARVKAFNKTG VSPYSKTLVL QTSEVAWFAF
DPGSAHSDII LSNDNLTVTC SSYDDRVVLG KTGFSKGIHY WELTVDRYDN HPDPAFGVAR
MDVMKDVMLG KDDKAWAMYV DNNRSWFMHN NSHTNRTEGG ITKGATIGVL LDLNRKNLTF
FINDEQQGPI AFDNVEGLFF PAVSLNRNVQ VTLHTGLPVP DFYSSRASIA

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
1	51	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
10	47	Domain	Zinc finger, RING-type	IPR001841	PS50089
10	131	Domain	Zinc finger, RING-type	IPR001841	SM00184
25	34	Conserved_site	Zinc finger, RING-type, conserved site	IPR017907	PS00518
163	212	Domain	B-box-type zinc finger	IPR000315	SM00336
163	212	Domain	B-box-type zinc finger	IPR000315	PS50119
224	266	Domain	B-box-type zinc finger	IPR000315	SM00336
224	266	Domain	B-box-type zinc finger	IPR000315	PS50119
225	265	Domain	B-box-type zinc finger	IPR000315	PF00643
273	399	Domain	B-box, C-terminal	IPR003649	SM00502
374	432	Domain	COS domain	IPR017903	PS51262
434	536	Homologous_superfamily	Immunoglobulin-like fold	IPR013783	G3DSA:2.60.40.10
437	533	Homologous_superfamily	Fibronectin type III superfamily	IPR036116	SSF49265
439	522	Domain	Fibronectin type III	IPR003961	SM00060
440	535	Domain	Fibronectin type III	IPR003961	PS50853
453	532	Domain	Fibronectin type III	IPR003961	cd00063
454	525	Domain	Fibronectin type III	IPR003961	PF00041
504	701	Homologous_superfamily	Concanavalin A-like lectin/glucanase domain superfamily	IPR013320	SSF49899
517	702	Domain	B30.2/SPRY domain	IPR001870	PS50188
540	695	Homologous_superfamily	B30.2/SPRY domain superfamily	IPR043136	G3DSA:2.60.120.920
576	697	Domain	SPRY domain	IPR003877	SM00449
578	696	Domain	SPRY domain	IPR003877	PF00622

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000041
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	Biological Process	IDA	PMID:20085810
GO:0005737	cytoplasm	Cellular Component	IEA	GO_REF:0000120
GO:0005856	cytoskeleton	Cellular Component	IEA	GO_REF:0000120
GO:0008021	synaptic vesicle	Cellular Component	IEA	GO_REF:0000044
GO:0030425	dendrite	Cellular Component	IEA	GO_REF:0000044
GO:0031410	cytoplasmic vesicle	Cellular Component	IEA	GO_REF:0000043
GO:0042995	cell projection	Cellular Component	IEA	GO_REF:0000043
GO:0045202	synapse	Cellular Component	IEA	GO_REF:0000043
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000120
GO:0016740	transferase activity	Molecular Function	IEA	GO_REF:0000043
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000120
GO:0005515	protein binding	Molecular Function	IPI	PMID:16189514
GO:0019904	protein domain specific binding	Molecular Function	IPI	PMID:22084112
GO:0042803	protein homodimerization activity	Molecular Function	IPI	PMID:11331580
GO:0061630	ubiquitin protein ligase activity	Molecular Function	IEA	GO_REF:0000003

Enzyme–Substrate Interactions ▾


P50552	VASP	Yes	No	Yes	No	16189514, 32296183	EBI-757861	E3-specific
Q9C026	TRIM9	Yes	Yes	No	Yes	—	No	E3-specific

Data Usage Statement and License Agreement

Ownership and Copyright

The Database, including all associated datasets, metadata, and documentation, is the intellectual property of the PROXIDRUGs consortium and the InnoDATA project.
The content of the Database is protected under applicable copyright and database protection laws.

Permitted Use

The Database is provided for research, academic, and non-commercial purposes only, unless explicitly stated otherwise.
Users are permitted to:
- Access, download, and use the data.
- Modify or build upon the data for academic, educational, or scientific purposes.
- Share derived datasets, analyses, or visualizations with proper citation and explicit acknowledgment of “The Human E3 Ligome” project.

Prohibited Use

Use the Database or any derivative works for commercial purposes without prior written consent from the PROXIDRUGs consortia (InnoDATA PIs).
Redistribute or republish the Database (or substantial parts of it) without proper credit and adherence to the license terms.
Misrepresent the data, alter metadata to mislead, or use it in a way that violates ethical or scientific standards.

Licensing

Unless otherwise stated, the Database is licensed under the Creative Commons Attribution 4.0 International License (CC BY 4.0).
This license allows redistribution and adaptation, provided appropriate credit is given.
Contributions (e.g., data corrections, additions, or scripts) can be made through merge requests on GitLab.
Contributors must agree to license their contributions under the same CC BY 4.0 license.

Citation Requirements

If you use or refer to the Database in your publications, reports, or presentations, you must cite the paper: Dutta et al. (2025, preprint)

Contact and Support

For inquiries, permissions, or support regarding the Database, please contact: Dr. Ramachandra M. Bhaskara, Goethe University Frankfurt.
Email: bhaskara@med.uni-frankfurt.de.
Website maintained by Alberto Cristiani, Arghya Dutta, and Siddhanta V. Nikte.

Substrate	Name	Known ESI (UbiBrowser)	Known ESI (UbiNet)	PPI (IntAct direct) PSI-MI score ≥ 0.5	PPI (IntAct indirect) PSI-MI scores ≥ 0.5 for both PPIs	PubMed Ref.	IntAct Ref.	Substrate Specificity
P50552	VASP	Yes	No	Yes	No	16189514, 32296183	EBI-757861	E3-specific
Q9C026	TRIM9	Yes	Yes	No	Yes	—	No	E3-specific