TRI15

Details:

UniProt Entry: Q9C019
Gene: TRIM15
Class: RING
Family: RING5
Protein length: 465
Database confidence: 0.625
InterPro: InterPro Entry
Mode of Action: Standalone
AlphaFold Model: Link
PDB Structures: 7qs2

Protein Sequence ▾

>Q9C019
MPATPSLKVV HELPACTLCA GPLEDAVTIP CGHTFCRLCL PALSQMGAQS SGKILLCPLC
QEEEQAETPM APVPLGPLGE TYCEEHGEKI YFFCENDAEF LCVFCREGPT HQAHTVGFLD
EAIQPYRDRL RSRLEALSTE RDEIEDVKCQ EDQKLQVLLT QIESKKHQVE TAFERLQQEL
EQQRCLLLAR LRELEQQIWK ERDEYITKVS EEVTRLGAQV KELEEKCQQP ASELLQDVRV
NQSRCEMKTF VSPEAISPDL VKKIRDFHRK ILTLPEMMRM FSENLAHHLE IDSGVITLDP
QTASRSLVLS EDRKSVRYTR QKKSLPDSPL RFDGLPAVLG FPGFSSGRHR WQVDLQLGDG
GGCTVGVAGE GVRRKGEMGL SAEDGVWAVI ISHQQCWAST SPGTDLPLSE IPRGVRVALD
YEAGQVTLHN AQTQEPIFTF TASFSGKVFP FFAVWKKGSC LTLKG

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
11	68	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
16	60	Domain	Zinc finger, RING-type	IPR001841	SM00184
16	61	Domain	Zinc finger, RING-type	IPR001841	PS50089
16	58	Domain	Zinc finger, RING-type, eukaryotic	IPR027370	PF13445
31	40	Conserved_site	Zinc finger, RING-type, conserved site	IPR017907	PS00518
78	119	Domain	B-box-type zinc finger	IPR000315	SM00336
78	119	Domain	B-box-type zinc finger	IPR000315	PS50119
80	116	Domain	B-box-type zinc finger	IPR000315	PF00643
276	465	Domain	B30.2/SPRY domain	IPR001870	PS50188
292	309	Domain	Butyrophylin-like, SPRY domain	IPR003879	PR01407
293	345	Domain	SPRY-associated	IPR006574	SM00589
293	464	Homologous_superfamily	B30.2/SPRY domain superfamily	IPR043136	G3DSA:2.60.120.920
296	459	Homologous_superfamily	Concanavalin A-like lectin/glucanase domain superfamily	IPR013320	SSF49899
296	344	Domain	SPRY-associated	IPR006574	PF13765
309	326	Domain	Butyrophylin-like, SPRY domain	IPR003879	PR01407
331	355	Domain	Butyrophylin-like, SPRY domain	IPR003879	PR01407
346	464	Domain	SPRY domain	IPR003877	SM00449
348	457	Domain	SPRY domain	IPR003877	PF00622
363	376	Domain	Butyrophylin-like, SPRY domain	IPR003879	PR01407
406	430	Domain	Butyrophylin-like, SPRY domain	IPR003879	PR01407
436	454	Domain	Butyrophylin-like, SPRY domain	IPR003879	PR01407

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0045087	innate immune response	Biological Process	IEA	GO_REF:0000117
GO:0007249	canonical NF-kappaB signal transduction	Biological Process	IDA	PMID:27995356
GO:0070534	protein K63-linked ubiquitination	Biological Process	IDA	PMID:27995356
GO:0007500	mesodermal cell fate determination	Biological Process	TAS	PMID:10207104
GO:0032481	positive regulation of type I interferon production	Biological Process	IMP	PMID:23077300
GO:0044790	suppression of viral release by host	Biological Process	IDA	PMID:18248090
GO:0045893	positive regulation of DNA-templated transcription	Biological Process	IEA	GO_REF:0000108
GO:1900246	positive regulation of RIG-I signaling pathway	Biological Process	IMP	PMID:23077300
GO:1901223	negative regulation of non-canonical NF-kappaB signal transduction	Biological Process	IDA	PMID:34871740
GO:1901253	negative regulation of intracellular transport of viral material	Biological Process	IMP	PMID:18248090
GO:0005634	nucleus	Cellular Component	IEA	GO_REF:0000120
GO:0005737	cytoplasm	Cellular Component	IEA	GO_REF:0000120
GO:0005925	focal adhesion	Cellular Component	IEA	GO_REF:0000044
GO:0070161	anchoring junction	Cellular Component	IEA	GO_REF:0000043
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000120
GO:0016740	transferase activity	Molecular Function	IEA	GO_REF:0000043
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000120
GO:0003713	transcription coactivator activity	Molecular Function	IDA	PMID:23077300
GO:0005515	protein binding	Molecular Function	IPI	PMID:25416956
GO:0061630	ubiquitin protein ligase activity	Molecular Function	IBA	GO_REF:0000033
GO:0140313	molecular sequestering activity	Molecular Function	IDA	PMID:34871740

Enzyme–Substrate Interactions ▾


P02647	APOA1	Yes	No	No	No	—	No	E3-specific

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