TRI31

Details:

UniProt Entry: Q9BZY9
Gene: TRIM31
Class: RING
Family: RING5
Protein length: 425
Database confidence: 1.0
InterPro: InterPro Entry
Mode of Action: Standalone
AlphaFold Model: Link
PDB Structures: 2ysj, 2ysl

Protein Sequence ▾

>Q9BZY9
MASGQFVNKL QEEVICPICL DILQKPVTID CGHNFCLKCI TQIGETSCGF FKCPLCKTSV
RKNAIRFNSL LRNLVEKIQA LQASEVQSKR KEATCPRHQE MFHYFCEDDG KFLCFVCRES
KDHKSHNVSL IEEAAQNYQG QIQEQIQVLQ QKEKETVQVK AQGVHRVDVF TDQVEHEKQR
ILTEFELLHQ VLEEEKNFLL SRIYWLGHEG TEAGKHYVAS TEPQLNDLKK LVDSLKTKQN
MPPRQLLEDI KVVLCRSEEF QFLNPTPVPL ELEKKLSEAK SRHDSITGSL KKFKDQLQAD
RKKDENRFFK SMNKNDMKSW GLLQKNNHKM NKTSEPGSSS AGGRTTSGPP NHHSSAPSHS
LFRASSAGKV TFPVCLLASY DEISGQGASS QDTKTFDVAL SEELHAALSE WLTAIRAWFC
EVPSS

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
1	80	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
16	57	Domain	Zinc finger, RING-type	IPR001841	PS50089
16	56	Domain	Zinc finger, RING-type	IPR001841	SM00184
31	40	Conserved_site	Zinc finger, RING-type, conserved site	IPR017907	PS00518
90	131	Domain	B-box-type zinc finger	IPR000315	SM00336
90	131	Domain	B-box-type zinc finger	IPR000315	PS50119
91	130	Domain	B-box-type zinc finger	IPR000315	PF00643
103	120	Domain	Zinc finger, B-box, chordata	IPR020457	PR01406
122	136	Domain	Zinc finger, B-box, chordata	IPR020457	PR01406

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0044546	NLRP3 inflammasome complex assembly	Biological Process	IDA	PMID:35114687
GO:0002376	immune system process	Biological Process	IEA	GO_REF:0000043
GO:0006511	ubiquitin-dependent protein catabolic process	Biological Process	IDA	PMID:27929086
GO:0006954	inflammatory response	Biological Process	IEA	GO_REF:0000043
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000041
GO:0019076	viral release from host cell	Biological Process	IMP	PMID:18248090
GO:0032897	negative regulation of viral transcription	Biological Process	IDA	PMID:18248090
GO:0045087	innate immune response	Biological Process	IBA	GO_REF:0000033
GO:0045893	positive regulation of DNA-templated transcription	Biological Process	IEA	GO_REF:0000108
GO:0046597	host-mediated suppression of symbiont invasion	Biological Process	IMP	PMID:18248090
GO:0051607	defense response to virus	Biological Process	IEA	GO_REF:0000043
GO:0070534	protein K63-linked ubiquitination	Biological Process	IDA	PMID:27992402
GO:0070936	protein K48-linked ubiquitination	Biological Process	IDA	PMID:27929086
GO:0140374	antiviral innate immune response	Biological Process	IDA	PMID:27992402
GO:1900226	negative regulation of NLRP3 inflammasome complex assembly	Biological Process	IDA	PMID:27929086
GO:0005737	cytoplasm	Cellular Component	IEA	GO_REF:0000120
GO:0005739	mitochondrion	Cellular Component	IEA	GO_REF:0000120
GO:0005829	cytosol	Cellular Component	TAS	Reactome:R-HSA-1031716
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000120
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0061630	ubiquitin protein ligase activity	Molecular Function	IEA	GO_REF:0000003
GO:0005515	protein binding	Molecular Function	IPI	PMID:25416956
GO:0003713	transcription coactivator activity	Molecular Function	IDA	PMID:23077300
GO:0016740	transferase activity	Molecular Function	IEA	GO_REF:0000043

Enzyme–Substrate Interactions ▾


Q9NQ88	TIGAR	Yes	No	No	No	—	No	E3-specific
Q9BZY9	TRI31	Yes	Yes	No	No	—	No	E3-specific

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If you use or refer to the Database in your publications, reports, or presentations, you must cite the paper: Dutta et al. (2025, preprint)

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For inquiries, permissions, or support regarding the Database, please contact: Dr. Ramachandra M. Bhaskara, Goethe University Frankfurt.
Email: bhaskara@med.uni-frankfurt.de.
Website maintained by Alberto Cristiani, Arghya Dutta, and Siddhanta V. Nikte.

Substrate	Name	Known ESI (UbiBrowser)	Known ESI (UbiNet)	PPI (IntAct direct) PSI-MI score ≥ 0.5	PPI (IntAct indirect) PSI-MI scores ≥ 0.5 for both PPIs	PubMed Ref.	IntAct Ref.	Substrate Specificity
Q9NQ88	TIGAR	Yes	No	No	No	—	No	E3-specific
Q9BZY9	TRI31	Yes	Yes	No	No	—	No	E3-specific