TRIM8

Details:

UniProt Entry: Q9BZR9
Gene: TRIM8
Class: RING
Family: RING9
Protein length: 551
Database confidence: 0.875
InterPro: InterPro Entry
Mode of Action: Standalone
AlphaFold Model: Link

Protein Sequence ▾

>Q9BZR9
MAENWKNCFE EELICPICLH VFVEPVQLPC KHNFCRGCIG EAWAKDSGLV RCPECNQAYN
QKPGLEKNLK LTNIVEKFNA LHVEKPPAAL HCVFCRRGPP LPAQKVCLRC EAPCCQSHVQ
THLQQPSTAR GHLLVEADDV RAWSCPQHNA YRLYHCEAEQ VAVCQYCCYY SGAHQGHSVC
DVEIRRNEIR KMLMKQQDRL EEREQDIEDQ LYKLESDKRL VEEKVNQLKE EVRLQYEKLH
QLLDEDLRQT VEVLDKAQAK FCSENAAQAL HLGERMQEAK KLLGSLQLLF DKTEDVSFMK
NTKSVKILMD RTQTCTSSSL SPTKIGHLNS KLFLNEVAKK EKQLRKMLEG PFSTPVPFLQ
SVPLYPCGVS SSGAEKRKHS TAFPEASFLE TSSGPVGGQY GAAGTASGEG QSGQPLGPCS
STQHLVALPG GAQPVHSSPV FPPSQYPNGS AAQQPMLPQY GGRKILVCSV DNCYCSSVAN
HGGHQPYPRS GHFPWTVPSQ EYSHPLPPTP SVPQSLPSLA VRDWLDASQQ PGHQDFYRVY
GQPSTKHYVT S

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
4	85	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
15	55	Domain	Zinc finger, C3HC4 RING-type	IPR018957	PF00097
15	55	Domain	Zinc finger, RING-type	IPR001841	SM00184
15	56	Domain	Zinc finger, RING-type	IPR001841	PS50089
30	39	Conserved_site	Zinc finger, RING-type, conserved site	IPR017907	PS00518

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0002376	immune system process	Biological Process	IEA	GO_REF:0000043
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000117
GO:0044790	suppression of viral release by host	Biological Process	IEA	GO_REF:0000117
GO:0045087	innate immune response	Biological Process	IEA	GO_REF:0000120
GO:0007249	canonical NF-kappaB signal transduction	Biological Process	IDA	PMID:34871740
GO:0019827	stem cell population maintenance	Biological Process	IEA	GO_REF:0000107
GO:1900182	positive regulation of protein localization to nucleus	Biological Process	IEA	GO_REF:0000107
GO:0010508	positive regulation of autophagy	Biological Process	IMP	PMID:26347139
GO:0032897	negative regulation of viral transcription	Biological Process	IEA	GO_REF:0000107
GO:0043123	positive regulation of canonical NF-kappaB signal transduction	Biological Process	IDA	PMID:23077300
GO:0045893	positive regulation of DNA-templated transcription	Biological Process	IEA	GO_REF:0000108
GO:0046597	host-mediated suppression of symbiont invasion	Biological Process	IEA	GO_REF:0000107
GO:0070534	protein K63-linked ubiquitination	Biological Process	IDA	PMID:27995356
GO:0005634	nucleus	Cellular Component	IEA	GO_REF:0000117
GO:0005829	cytosol	Cellular Component	IEA	GO_REF:0000117
GO:0005737	cytoplasm	Cellular Component	IDA	PMID:23152791
GO:0016604	nuclear body	Cellular Component	IEA	GO_REF:0000044
GO:0016605	PML body	Cellular Component	IDA	PMID:11331580
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0016740	transferase activity	Molecular Function	IEA	GO_REF:0000043
GO:0061630	ubiquitin protein ligase activity	Molecular Function	IEA	GO_REF:0000117
GO:0003713	transcription coactivator activity	Molecular Function	IDA	PMID:23077300
GO:0005515	protein binding	Molecular Function	IPI	PMID:19549727
GO:0042802	identical protein binding	Molecular Function	IPI	PMID:22493164
GO:0042803	protein homodimerization activity	Molecular Function	IPI	PMID:11331580

Enzyme–Substrate Interactions ▾


O15524	SOCS1	Yes	Yes	No	No	—	No	E3-specific

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