NSD3

Details:

UniProt Entry: Q9BZ95
Gene: NSD3
Class: RING
Family: RING10
Protein length: 1437
Database confidence: 0.125
InterPro: InterPro Entry
Mode of Action: Unclassified
AlphaFold Model: Link
PDB Structures: 2daq, 2ncz, 2nd1, 4gnd, 4gne, 4gnf, 4gng, 4rxj, 5upd, 6cen, 6g24, 6g25, 6g27, 6g29, 6g2b, 6g2c, 6g2e, 6g2f, 6g2o, 6g3p, 6g3t, 7crp, 7crq, 7crr, 7jyn

Protein Sequence ▾

>Q9BZ95
MDFSFSFMQG IMGNTIQQPP QLIDSANIRQ EDAFDNNSDI AEDGGQTPYE ATLQQGFQYP
ATTEDLPPLT NGYPSSISVY ETQTKYQSYN QYPNGSANGF GAVRNFSPTD YYHSEIPNTR
PHEILEKPSP PQPPPPPSVP QTVIPKKTGS PEIKLKITKT IQNGRELFES SLCGDLLNEV
QASEHTKSKH ESRKEKRKKS NKHDSSRSEE RKSHKIPKLE PEEQNRPNER VDTVSEKPRE
EPVLKEEAPV QPILSSVPTT EVSTGVKFQV GDLVWSKVGT YPWWPCMVSS DPQLEVHTKI
NTRGAREYHV QFFSNQPERA WVHEKRVREY KGHKQYEELL AEATKQASNH SEKQKIRKPR
PQRERAQWDI GIAHAEKALK MTREERIEQY TFIYIDKQPE EALSQAKKSV ASKTEVKKTR
RPRSVLNTQP EQTNAGEVAS SLSSTEIRRH SQRRHTSAEE EEPPPVKIAW KTAAARKSLP
ASITMHKGSL DLQKCNMSPV VKIEQVFALQ NATGDGKFID QFVYSTKGIG NKTEISVRGQ
DRLIISTPNQ RNEKPTQSVS SPEATSGSTG SVEKKQQRRS IRTRSESEKS TEVVPKKKIK
KEQVETVPQA TVKTGLQKGA SEISDSCKPL KKRSRASTDV EMTSSAYRDT SDSDSRGLSD
LQVGFGKQVD SPSATADADV SDVQSMDSSL SRRGTGMSKK DTVCQICESS GDSLIPCEGE
CCKHFHLECL GLASLPDSKF ICMECKTGQH PCFSCKVSGK DVKRCSVGAC GKFYHEACVR
KFPTAIFESK GFRCPQHCCS ACSMEKDIHK ASKGRMMRCL RCPVAYHSGD ACIAAGSMLV
SSYILICSNH SKRSSNSSAV NVGFCFVCAR GLIVQDHSDP MFSSYAYKSH YLLNESNRAE
LMKLPMIPSS SASKKKCEKG GRLLCCESCP ASFHPECLSI EMPEGCWNCN DCKAGKKLHY
KQIVWVKLGN YRWWPAEICN PRSVPLNIQG LKHDLGDFPV FFFGSHDYYW VHQGRVFPYV
EGDKSFAEGQ TSINKTFKKA LEEAAKRFQE LKAQRESKEA LEIEKNSRKP PPYKHIKANK
VIGKVQIQVA DLSEIPRCNC KPADENPCGL ESECLNRMLQ YECHPQVCPA GDRCQNQCFT
KRLYPDAEII KTERRGWGLR TKRSIKKGEF VNEYVGELID EEECRLRIKR AHENSVTNFY
MLTVTKDRII DAGPKGNYSR FMNHSCNPNC ETQKWTVNGD VRVGLFALCD IPAGMELTFN
YNLDCLGNGR TECHCGADNC SGFLGVRPKS ACASTNEEKA KNAKLKQKRR KIKTEPKQMH
EDYCFQCGDG GELVMCDKKD CPKAYHLLCL NLTQPPYGKW ECPWHQCDEC SSAAVSFCEF
CPHSFCKDHE KGALVPSALE GRLCCSEHDP MAPVSPEYWS KIKCKWESQD HGEEVKE

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
268	331	Domain	PWWP domain	IPR000313	SM00293
270	333	Domain	PWWP domain	IPR000313	PS50812
271	379	Domain	PWWP domain	IPR000313	PF00855
681	748	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
698	756	Homologous_superfamily	Zinc finger, FYVE/PHD-type	IPR011011	SSF57903
701	748	Domain	Zinc finger, PHD-finger	IPR019787	PS50016
703	746	Domain	Zinc finger, PHD-type	IPR001965	SM00249
704	745	Conserved_site	Zinc finger, PHD-type, conserved site	IPR019786	PS01359
749	813	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
751	798	Domain	Zinc finger, PHD-type	IPR001965	SM00249
799	851	Domain	Zinc finger, PHD-type	IPR001965	SM00249
912	954	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
916	967	Homologous_superfamily	Zinc finger, FYVE/PHD-type	IPR011011	SSF57903
916	953	Domain	Zinc finger, PHD-type	IPR001965	SM00249
958	1020	Domain	PWWP domain	IPR000313	SM00293
960	1022	Domain	PWWP domain	IPR000313	PS50812
962	1048	Domain	PWWP domain	IPR000313	PF00855
1057	1285	Homologous_superfamily	SET domain superfamily	IPR046341	G3DSA:2.170.270.10
1063	1275	Homologous_superfamily	SET domain superfamily	IPR046341	SSF82199
1093	1143	Domain	AWS domain	IPR006560	PS51215
1093	1144	Domain	AWS domain	IPR006560	SM00570
1104	1142	Domain	AWS domain	IPR006560	PF17907
1145	1262	Domain	SET domain	IPR001214	PS50280
1145	1268	Domain	SET domain	IPR001214	SM00317
1156	1262	Domain	SET domain	IPR001214	PF00856
1269	1285	Domain	Post-SET domain	IPR003616	SM00508
1269	1285	Domain	Post-SET domain	IPR003616	PS50868
1298	1366	Homologous_superfamily	Zinc finger, FYVE/PHD-type	IPR011011	SSF57903
1306	1413	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
1321	1368	Domain	Zinc finger, PHD-finger	IPR019787	PS50016
1323	1366	Domain	Zinc finger, PHD-type	IPR001965	SM00249
1364	1413	Domain	NSD, Cys-His rich domain	IPR041306	PF17982

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0006325	chromatin organization	Biological Process	IEA	GO_REF:0000043
GO:0006338	chromatin remodeling	Biological Process	IEA	GO_REF:0000120
GO:0006355	regulation of DNA-templated transcription	Biological Process	IBA	GO_REF:0000033
GO:0032259	methylation	Biological Process	IEA	GO_REF:0000043
GO:0045893	positive regulation of DNA-templated transcription	Biological Process	IMP	PMID:21555454
GO:0000785	chromatin	Cellular Component	IBA	GO_REF:0000033
GO:0005634	nucleus	Cellular Component	IBA	GO_REF:0000033
GO:0005654	nucleoplasm	Cellular Component	TAS	Reactome:R-HSA-5159245
GO:0005694	chromosome	Cellular Component	IEA	GO_REF:0000120
GO:0005515	protein binding	Molecular Function	IPI	PMID:21516116
GO:0008168	methyltransferase activity	Molecular Function	IEA	GO_REF:0000043
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0016740	transferase activity	Molecular Function	IEA	GO_REF:0000043
GO:0042054	histone methyltransferase activity	Molecular Function	IEA	GO_REF:0000002
GO:0042800	histone H3K4 methyltransferase activity	Molecular Function	IEA	GO_REF:0000117
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0046975	histone H3K36 methyltransferase activity	Molecular Function	IBA	GO_REF:0000033
GO:0046976	histone H3K27 methyltransferase activity	Molecular Function	IEA	GO_REF:0000117
GO:0140537	transcription regulator activator activity	Molecular Function	IMP	PMID:21555454
GO:0140938	histone H3 methyltransferase activity	Molecular Function	TAS	Reactome:R-HSA-5638333
GO:0140946	histone H3K4 dimethyltransferase activity	Molecular Function	IEA	GO_REF:0000120
GO:0140951	histone H3K27 trimethyltransferase activity	Molecular Function	IDA	PMID:16682010
GO:0140952	histone H3K27 dimethyltransferase activity	Molecular Function	IEA	GO_REF:0000120

Enzyme–Substrate Interactions ▾

Small Molecule Interactions ▾

Type	ChEMBL Compound ID	Source	pChEMBL	PDB Compound ID	PDB Codes	SMILES
E3 Binder	CHEMBL4778517	ChEMBL	6.77	EJE	—	Cc1cc(CN)cc(C)c1-c1ncn(C)c1-c1ccnc2cc(F)ccc12
E3 Binder	CHEMBL5277519	ChEMBL	6.69	—	—	Cc1ccc2c(-c3c(-c4c(C)cc(CN)cc4C)ncn3C)ccnc2c1
E3 Binder	CHEMBL4758943	ChEMBL	7.04	Q5D	—	N#Cc1ccc(C(=O)N(Cc2cccs2)C2CC2)cc1

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