RHBT2

Details:

UniProt Entry: Q9BYZ6
Gene: RHOBTB2
Class: Other E3 Components
Family: Adaptor
Protein length: 727
Database confidence: 0.375
InterPro: InterPro Entry
Mode of Action: unknown
AlphaFold Model: Link

Protein Sequence ▾

>Q9BYZ6
MDSDMDYERP NVETIKCVVV GDNAVGKTRL ICARACNATL TQYQLLATHV PTVWAIDQYR
VCQEVLERSR DVVDDVSVSL RLWDTFGDHH KDRRFAYGRS DVVVLCFSIA NPNSLHHVKT
MWYPEIKHFC PRAPVILVGC QLDLRYADLE AVNRARRPLA RPIKPNEILP PEKGREVAKE
LGIPYYETSV VAQFGIKDVF DNAIRAALIS RRHLQFWKSH LRNVQRPLLQ APFLPPKPPP
PIIVVPDPPS SSEECPAHLL EDPLCADVIL VLQERVRIFA HKIYLSTSSS KFYDLFLMDL
SEGELGGPSE PGGTHPEDHQ GHSDQHHHHH HHHHGRDFLL RAASFDVCES VDEAGGSGPA
GLRASTSDGI LRGNGTGYLP GRGRVLSSWS RAFVSIQEEM AEDPLTYKSR LMVVVKMDSS
IQPGPFRAVL KYLYTGELDE NERDLMHIAH IAELLEVFDL RMMVANILNN EAFMNQEITK
AFHVRRTNRV KECLAKGTFS DVTFILDDGT ISAHKPLLIS SCDWMAAMFG GPFVESSTRE
VVFPYTSKSC MRAVLEYLYT GMFTSSPDLD DMKLIILANR LCLPHLVALT EQYTVTGLME
ATQMMVDIDG DVLVFLELAQ FHCAYQLADW CLHHICTNYN NVCRKFPRDM KAMSPENQEY
FEKHRWPPVW YLKEEDHYQR ARKEREKEDY LHLKRQPKRR WLFWNSPSSP SSSAASSSSP
SSSSAVV

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
8	270	Family	Small GTPase	IPR001806	PS51421
11	216	Homologous_superfamily	P-loop containing nucleoside triphosphate hydrolase	IPR027417	SSF52540
11	212	Homologous_superfamily	P-loop containing nucleoside triphosphate hydrolase	IPR027417	G3DSA:3.40.50.300
14	209	Family	Small GTPase Rho	IPR003578	PTHR24072
16	207	Family	Small GTPase	IPR001806	PF00071
17	210	Family	Small GTPase	IPR001806	SM00174
240	470	Homologous_superfamily	SKP1/BTB/POZ domain superfamily	IPR011333	SSF54695
242	329	Homologous_superfamily	SKP1/BTB/POZ domain superfamily	IPR011333	G3DSA:3.30.710.10
266	472	Domain	BTB/POZ domain	IPR000210	SM00225
266	442	Domain	BTB/POZ domain	IPR000210	PS50097
383	488	Homologous_superfamily	SKP1/BTB/POZ domain superfamily	IPR011333	G3DSA:3.30.710.10
385	470	Domain	BTB/POZ domain	IPR000210	PF00651
487	593	Homologous_superfamily	SKP1/BTB/POZ domain superfamily	IPR011333	SSF54695
489	645	Homologous_superfamily	SKP1/BTB/POZ domain superfamily	IPR011333	G3DSA:3.30.710.10
491	594	Domain	BTB/POZ domain	IPR000210	PF00651
500	567	Domain	BTB/POZ domain	IPR000210	PS50097
500	598	Domain	BTB/POZ domain	IPR000210	SM00225

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0007264	small GTPase-mediated signal transduction	Biological Process	IEA	GO_REF:0000002
GO:0006511	ubiquitin-dependent protein catabolic process	Biological Process	IMP	PMID:27941885
GO:0007015	actin filament organization	Biological Process	IBA	GO_REF:0000033
GO:0007163	establishment or maintenance of cell polarity	Biological Process	IBA	GO_REF:0000033
GO:0007165	signal transduction	Biological Process	IBA	GO_REF:0000033
GO:0008360	regulation of cell shape	Biological Process	IBA	GO_REF:0000033
GO:0016567	protein ubiquitination	Biological Process	IDA	PMID:27941885
GO:0030865	cortical cytoskeleton organization	Biological Process	IBA	GO_REF:0000033
GO:0032956	regulation of actin cytoskeleton organization	Biological Process	IBA	GO_REF:0000033
GO:0010008	endosome membrane	Cellular Component	IEA	GO_REF:0000117
GO:0005856	cytoskeleton	Cellular Component	IBA	GO_REF:0000033
GO:0005886	plasma membrane	Cellular Component	IBA	GO_REF:0000033
GO:0031410	cytoplasmic vesicle	Cellular Component	IBA	GO_REF:0000033
GO:0042995	cell projection	Cellular Component	IBA	GO_REF:0000033
GO:0031463	Cul3-RING ubiquitin ligase complex	Cellular Component	IDA	PMID:27941885
GO:0003924	GTPase activity	Molecular Function	IEA	GO_REF:0000002
GO:0005525	GTP binding	Molecular Function	IEA	GO_REF:0000120
GO:0000166	nucleotide binding	Molecular Function	IEA	GO_REF:0000043
GO:0005515	protein binding	Molecular Function	IPI	PMID:15107402
GO:0019901	protein kinase binding	Molecular Function	IBA	GO_REF:0000033
GO:1990756	ubiquitin-like ligase-substrate adaptor activity	Molecular Function	IDA	PMID:27941885

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