BACH2

Details:

UniProt Entry: Q9BYV9
Gene: BACH2
Class: Other E3 Components
Family: Adaptor
Protein length: 841
Database confidence: 0.25
InterPro: InterPro Entry
Mode of Action: unknown
AlphaFold Model: Link

Protein Sequence ▾

>Q9BYV9
MSVDEKPDSP MYVYESTVHC TNILLGLNDQ RKKDILCDVT LIVERKEFRA HRAVLAACSE
YFWQALVGQT KNDLVVSLPE EVTARGFGPL LQFAYTAKLL LSRENIREVI RCAEFLRMHN
LEDSCFSFLQ TQLLNSEDGL FVCRKDAACQ RPHEDCENSA GEEEDEEEET MDSETAKMAC
PRDQMLPEPI SFEAAAIPVA EKEEALLPEP DVPTDTKESS EKDALTQYPR YKKYQLACTK
NVYNASSHST SGFASTFRED NSSNSLKPGL ARGQIKSEPP SEENEEESIT LCLSGDEPDA
KDRAGDVEMD RKQPSPAPTP TAPAGAACLE RSRSVASPSC LRSLFSITKS VELSGLPSTS
QQHFARSPAC PFDKGITQGD LKTDYTPFTG NYGQPHVGQK EVSNFTMGSP LRGPGLEALC
KQEGELDRRS VIFSSSACDQ VSTSVHSYSG VSSLDKDLSE PVPKGLWVGA GQSLPSSQAY
SHGGLMADHL PGRMRPNTSC PVPIKVCPRS PPLETRTRTS SSCSSYSYAE DGSGGSPCSL
PLCEFSSSPC SQGARFLATE HQEPGLMGDG MYNQVRPQIK CEQSYGTNSS DESGSFSEAD
SESCPVQDRG QEVKLPFPVD QITDLPRNDF QMMIKMHKLT SEQLEFIHDV RRRSKNRIAA
QRCRKRKLDC IQNLECEIRK LVCEKEKLLS ERNQLKACMG ELLDNFSCLS QEVCRDIQSP
EQIQALHRYC PVLRPMDLPT ASSINPAPLG AEQNIAASQC AVGENVPCCL EPGAAPPGPP
WAPSNTSENC TSGRRLEGTD PGTFSERGPP LEPRSQTVTV DFCQEMTDKC TTDEQPRKDY
T

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
8	138	Homologous_superfamily	SKP1/BTB/POZ domain superfamily	IPR011333	G3DSA:3.30.710.10
10	132	Homologous_superfamily	SKP1/BTB/POZ domain superfamily	IPR011333	SSF54695
27	132	Domain	BTB/POZ domain	IPR000210	PF00651
37	103	Domain	BTB/POZ domain	IPR000210	PS50097
37	133	Domain	BTB/POZ domain	IPR000210	SM00225
607	669	Homologous_superfamily	Transcription factor, Skn-1-like, DNA-binding domain superfamily	IPR008917	SSF47454
618	696	Domain	Basic leucine zipper domain, Maf-type	IPR004826	PF03131
640	710	Domain	BACH, basic leucine zipper (bZIP) domain	IPR043321	cd14719
644	708	Domain	Basic-leucine zipper domain	IPR004827	SM00338
651	696	Domain	Basic-leucine zipper domain	IPR004827	PS50217
651	666	Domain	Basic-leucine zipper domain	IPR004827	PS00036
655	702	Homologous_superfamily	Basic-leucine zipper domain superfamily	IPR046347	SSF57959

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0000122	negative regulation of transcription by RNA polymerase II	Biological Process	IEA	GO_REF:0000107
GO:0006355	regulation of DNA-templated transcription	Biological Process	IEA	GO_REF:0000120
GO:0006357	regulation of transcription by RNA polymerase II	Biological Process	IBA	GO_REF:0000033
GO:0051170	import into nucleus	Biological Process	ISS	GO_REF:0000024
GO:0090721	primary adaptive immune response involving T cells and B cells	Biological Process	IMP	PMID:28530713
GO:0005654	nucleoplasm	Cellular Component	IDA	GO_REF:0000052
GO:0005829	cytosol	Cellular Component	IDA	GO_REF:0000052
GO:0000785	chromatin	Cellular Component	ISA	GO_REF:0000113
GO:0005634	nucleus	Cellular Component	IEA	GO_REF:0000120
GO:0005737	cytoplasm	Cellular Component	IEA	GO_REF:0000120
GO:0090575	RNA polymerase II transcription regulator complex	Cellular Component	ISS	GO_REF:0000114
GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Molecular Function	IBA	GO_REF:0000033
GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	Molecular Function	IBA	GO_REF:0000033
GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	Molecular Function	IEA	GO_REF:0000107
GO:0003677	DNA binding	Molecular Function	IEA	GO_REF:0000120
GO:0003700	DNA-binding transcription factor activity	Molecular Function	IEA	GO_REF:0000120
GO:0005515	protein binding	Molecular Function	IPI	PMID:23661758
GO:1990837	sequence-specific double-stranded DNA binding	Molecular Function	IDA	PMID:28473536

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