TRI54

Details:

UniProt Entry: Q9BYV2
Gene: TRIM54
Class: RING
Family: RING5
Protein length: 358
Database confidence: 0.625
InterPro: InterPro Entry
Mode of Action: Complex
AlphaFold Model: Link
PDB Structures: 3q1d

Protein Sequence ▾

>Q9BYV2
MNFTVGFKPL LGDAHSMDNL EKQLICPICL EMFSKPVVIL PCQHNLCRKC ANDVFQASNP
LWQSRGSTTV SSGGRFRCPS CRHEVVLDRH GVYGLQRNLL VENIIDIYKQ ESSRPLHSKA
EQHLMCEEHE EEKINIYCLS CEVPTCSLCK VFGAHKDCEV APLPTIYKRQ KSELSDGIAM
LVAGNDRVQA VITQMEEVCQ TIEDNSRRQK QLLNQRFESL CAVLEERKGE LLQALAREQE
EKLQRVRGLI RQYGDHLEAS SKLVESAIQS MEEPQMALYL QQAKELINKV GAMSKVELAG
RPEPGYESME QFTVRVEHVA EMLRTIDFQP GASGEEEEVA PDGEEGSAGP EEERPDGP

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
13	114	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
24	82	Domain	TRIM54, RING finger, HC subclass	IPR042752	cd16761
26	82	Domain	Zinc finger, RING-type	IPR001841	PS50089
26	81	Domain	Zinc finger, RING-type	IPR001841	SM00184
26	79	Domain	Zinc finger, RING-type, eukaryotic	IPR027370	PF13445
42	51	Conserved_site	Zinc finger, RING-type, conserved site	IPR017907	PS00518
121	163	Domain	B-box-type zinc finger	IPR000315	SM00336
121	163	Domain	B-box-type zinc finger	IPR000315	PS50119
123	156	Domain	B-box-type zinc finger	IPR000315	PF00643
124	166	Domain	Tripartite motif-containing protein 54, B-box-type 2 zinc finger	IPR033492	cd19833
271	329	Domain	COS domain	IPR017903	PS51262

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0007026	negative regulation of microtubule depolymerization	Biological Process	IEA	GO_REF:0000107
GO:0007017	microtubule-based process	Biological Process	NAS	PMID:11243782
GO:0007165	signal transduction	Biological Process	NAS	PMID:11243782
GO:0030154	cell differentiation	Biological Process	IEA	GO_REF:0000043
GO:0045087	innate immune response	Biological Process	IBA	GO_REF:0000033
GO:0005737	cytoplasm	Cellular Component	IBA	GO_REF:0000033
GO:0005856	cytoskeleton	Cellular Component	IEA	GO_REF:0000120
GO:0005874	microtubule	Cellular Component	IEA	GO_REF:0000043
GO:0030018	Z disc	Cellular Component	IEA	GO_REF:0000044
GO:0005875	microtubule associated complex	Cellular Component	IEA	GO_REF:0000107
GO:0005515	protein binding	Molecular Function	IPI	PMID:25416956
GO:0008017	microtubule binding	Molecular Function	IEA	GO_REF:0000107
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000120
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0061630	ubiquitin protein ligase activity	Molecular Function	IBA	GO_REF:0000033

Enzyme–Substrate Interactions ▾

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