HOIL1

Details:

UniProt Entry: Q9BYM8
Gene: RBCK1
Class: RBR
Family: RBR
Protein length: 510
Database confidence: 1.0
InterPro: InterPro Entry
Mode of Action: Standalone
AlphaFold Model: Link
PDB Structures: 2crc, 2lgy, 4dbg, 7v8e, 8bvl, 8eaz

Protein Sequence ▾

>Q9BYM8
MDEKTKKAEE MALSLTRAVA GGDEQVAMKC AIWLAEQRVP LSVQLKPEVS PTQDIRLWVS
VEDAQMHTVT IWLTVRPDMT VASLKDMVFL DYGFPPVLQQ WVIGQRLARD QETLHSHGVR
QNGDSAYLYL LSARNTSLNP QELQRERQLR MLEDLGFKDL TLQPRGPLEP GPPKPGVPQE
PGRGQPDAVP EPPPVGWQCP GCTFINKPTR PGCEMCCRAR PEAYQVPASY QPDEEERARL
AGEEEALRQY QQRKQQQQEG NYLQHVQLDQ RSLVLNTEPA ECPVCYSVLA PGEAVVLREC
LHTFCRECLQ GTIRNSQEAE VSCPFIDNTY SCSGKLLERE IKALLTPEDY QRFLDLGISI
AENRSAFSYH CKTPDCKGWC FFEDDVNEFT CPVCFHVNCL LCKAIHEQMN CKEYQEDLAL
RAQNDVAARQ TTEMLKVMLQ QGEAMRCPQC QIVVQKKDGC DWIRCTVCHT EICWVTKGPR
WGPGGPGDTS GGCRCRVNGI PCHPSCQNCH

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
49	130	Homologous_superfamily	Ubiquitin-like domain superfamily	IPR029071	SSF54236
55	122	Domain	Ubiquitin-like domain	IPR000626	PS50053
192	220	Homologous_superfamily	Zinc finger, RanBP2-type superfamily	IPR036443	SSF90209
195	219	Domain	Zinc finger, RanBP2-type	IPR001876	SM00547
197	216	Domain	Zinc finger, RanBP2-type	IPR001876	PS01358
197	222	Domain	Zinc finger, RanBP2-type	IPR001876	PS50199
276	365	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
278	506	Domain	TRIAD supradomain	IPR044066	PS51873
282	324	Domain	Zinc finger, RING-type, eukaryotic	IPR027370	PF13445
282	324	Domain	Zinc finger, RING-type	IPR001841	PS50089
282	326	Domain	Zinc finger, RING-type	IPR001841	SM00184
300	309	Conserved_site	Zinc finger, RING-type, conserved site	IPR017907	PS00518

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0009893	positive regulation of metabolic process	Biological Process	IEA	GO_REF:0000117
GO:0010604	positive regulation of macromolecule metabolic process	Biological Process	IEA	GO_REF:0000117
GO:0080090	regulation of primary metabolic process	Biological Process	IEA	GO_REF:0000117
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000041
GO:0060546	negative regulation of necroptotic process	Biological Process	IEA	GO_REF:0000107
GO:2001238	positive regulation of extrinsic apoptotic signaling pathway	Biological Process	IEA	GO_REF:0000107
GO:0000209	protein polyubiquitination	Biological Process	IEA	GO_REF:0000107
GO:0032088	negative regulation of NF-kappaB transcription factor activity	Biological Process	IDA	PMID:17449468
GO:0042742	defense response to bacterium	Biological Process	IMP	PMID:28481331
GO:0043065	positive regulation of apoptotic process	Biological Process	IEA	GO_REF:0000107
GO:0043123	positive regulation of canonical NF-kappaB signal transduction	Biological Process	IBA	GO_REF:0000033
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	Biological Process	IBA	GO_REF:0000033
GO:0050852	T cell receptor signaling pathway	Biological Process	IDA	PMID:20005846
GO:0051092	positive regulation of NF-kappaB transcription factor activity	Biological Process	IDA	PMID:19136968
GO:0097039	protein linear polyubiquitination	Biological Process	IBA	GO_REF:0000033
GO:1901224	positive regulation of non-canonical NF-kappaB signal transduction	Biological Process	IEA	GO_REF:0000107
GO:0005829	cytosol	Cellular Component	TAS	Reactome:R-HSA-5357776
GO:0071797	LUBAC complex	Cellular Component	IBA	GO_REF:0000033
GO:0004842	ubiquitin-protein transferase activity	Molecular Function	IEA	GO_REF:0000117
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0016740	transferase activity	Molecular Function	IEA	GO_REF:0000043
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0005515	protein binding	Molecular Function	IPI	PMID:16643902
GO:0042802	identical protein binding	Molecular Function	IPI	PMID:25416956
GO:0043130	ubiquitin binding	Molecular Function	IBA	GO_REF:0000033
GO:0061630	ubiquitin protein ligase activity	Molecular Function	IEA	GO_REF:0000003
GO:1990757	ubiquitin ligase activator activity	Molecular Function	IEA	GO_REF:0000107

Enzyme–Substrate Interactions ▾


P48200	IREB2	Yes	Yes	No	No	—	No	E3-specific
Q9NYJ8	TAB2	Yes	Yes	No	No	—	No	E3-specific
O14867	BACH1	Yes	Yes	No	No	—	No	E3-specific
Q8N5C8	TAB3	Yes	Yes	No	No	—	No	E3-specific

Small Molecule Interactions ▾

Type	ChEMBL Compound ID	Source	pChEMBL	PDB Compound ID	PDB Codes	SMILES
E3 Binder	CHEMBL331627	ChEMBL	6.29	—	—	CN1C(=O)[C@]23CC4=CC=C[C@H](O)[C@H]4N2C(=O)[C@@]1(CO)SS3

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Substrate	Name	Known ESI (UbiBrowser)	Known ESI (UbiNet)	PPI (IntAct direct) PSI-MI score ≥ 0.5	PPI (IntAct indirect) PSI-MI scores ≥ 0.5 for both PPIs	PubMed Ref.	IntAct Ref.	Substrate Specificity
P48200	IREB2	Yes	Yes	No	No	—	No	E3-specific
Q9NYJ8	TAB2	Yes	Yes	No	No	—	No	E3-specific
O14867	BACH1	Yes	Yes	No	No	—	No	E3-specific
Q8N5C8	TAB3	Yes	Yes	No	No	—	No	E3-specific