PCGF6

Details:

UniProt Entry: Q9BYE7
Gene: PCGF6
Class: RING
Family: RING4
Protein length: 350
Database confidence: 0.75
InterPro: InterPro Entry
Mode of Action: Standalone
AlphaFold Model: Link
PDB Structures: 2djb

Protein Sequence ▾

>Q9BYE7
MEGVAVVTAG SVGAAKTEGA AALPPPPPVS PPALTPAPAA GEEGPAPLSE TGAPGCSGSR
PPELEPERSL GRFRGRFEDE DEELEEEEEL EEEEEEEEED MSHFSLRLEG GRQDSEDEEE
RLINLSELTP YILCSICKGY LIDATTITEC LHTFCKSCIV RHFYYSNRCP KCNIVVHQTQ
PLYNIRLDRQ LQDIVYKLVI NLEEREKKQM HDFYKERGLE VPKPAVPQPV PSSKGRSKKV
LESVFRIPPE LDMSLLLEFI GANEGTGHFK PLEKKFVRVS GEATIGHVEK FLRRKMGLDP
ACQVDIICGD HLLEQYQTLR EIRRAIGDAA MQDGLLVLHY GLVVSPLKIT

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
118	221	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
130	174	Domain	Polycomb group RING finger protein 6, C3HC4-type RING finger	IPR038037	cd16738
134	173	Domain	Zinc finger, RING-type	IPR001841	PS50089
134	172	Domain	Zinc finger, RING-type	IPR001841	SM00184
150	159	Conserved_site	Zinc finger, RING-type, conserved site	IPR017907	PS00518
252	341	Domain	Polycomb group RING finger protein 6, RAWUL	IPR046979	cd17085
265	340	Homologous_superfamily	Ubiquitin-like domain superfamily	IPR029071	SSF54236

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0000122	negative regulation of transcription by RNA polymerase II	Biological Process	IEA	GO_REF:0000107
GO:0006338	chromatin remodeling	Biological Process	IMP	PMID:26151332
GO:0006357	regulation of transcription by RNA polymerase II	Biological Process	IBA	GO_REF:0000033
GO:0045892	negative regulation of DNA-templated transcription	Biological Process	IEA	GO_REF:0000117
GO:0005634	nucleus	Cellular Component	IEA	GO_REF:0000120
GO:0031519	PcG protein complex	Cellular Component	IEA	GO_REF:0000117
GO:0005654	nucleoplasm	Cellular Component	TAS	Reactome:R-HSA-8953452
GO:0035102	PRC1 complex	Cellular Component	IBA	GO_REF:0000033
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0005515	protein binding	Molecular Function	IPI	PMID:21282530

Enzyme–Substrate Interactions ▾

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