TRI62

Details:

UniProt Entry: Q9BVG3
Gene: TRIM62
Class: RING
Family: RING5
Protein length: 475
Database confidence: 0.875
InterPro: InterPro Entry
Mode of Action: Standalone
AlphaFold Model: Link

Protein Sequence ▾

>Q9BVG3
MACSLKDELL CSICLSIYQD PVSLGCEHYF CRRCITEHWV RQEAQGARDC PECRRTFAEP
ALAPSLKLAN IVERYSSFPL DAILNARRAA RPCQAHDKVK LFCLTDRALL CFFCDEPALH
EQHQVTGIDD AFDELQRELK DQLQALQDSE REHTEALQLL KRQLAETKSS TKSLRTTIGE
AFERLHRLLR ERQKAMLEEL EADTARTLTD IEQKVQRYSQ QLRKVQEGAQ ILQERLAETD
RHTFLAGVAS LSERLKGKIH ETNLTYEDFP TSKYTGPLQY TIWKSLFQDI HPVPAALTLD
PGTAHQRLIL SDDCTIVAYG NLHPQPLQDS PKRFDVEVSV LGSEAFSSGV HYWEVVVAEK
TQWVIGLAHE AASRKGSIQI QPSRGFYCIV MHDGNQYSAC TEPWTRLNVR DKLDKVGVFL
DYDQGLLIFY NADDMSWLYT FREKFPGKLC SYFSPGQSHA NGKNVQPLRI NTVRI

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
1	83	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
11	53	Domain	Zinc finger, RING-type	IPR001841	SM00184
11	54	Domain	Zinc finger, RING-type	IPR001841	PS50089
26	35	Conserved_site	Zinc finger, RING-type, conserved site	IPR017907	PS00518
88	128	Domain	B-box-type zinc finger	IPR000315	PS50119
91	126	Domain	B-box-type zinc finger	IPR000315	PF00643
277	475	Domain	B30.2/SPRY domain	IPR001870	PS50188
284	471	Domain	TRIM62, PRY/SPRY domain	IPR035830	cd13744
289	471	Homologous_superfamily	Concanavalin A-like lectin/glucanase domain superfamily	IPR013320	SSF49899
290	474	Homologous_superfamily	B30.2/SPRY domain superfamily	IPR043136	G3DSA:2.60.120.920
293	310	Domain	Butyrophylin-like, SPRY domain	IPR003879	PR01407
294	347	Domain	SPRY-associated	IPR006574	SM00589
297	346	Domain	SPRY-associated	IPR006574	PF13765
333	357	Domain	Butyrophylin-like, SPRY domain	IPR003879	PR01407
348	466	Domain	SPRY domain	IPR003877	SM00449
351	456	Domain	SPRY domain	IPR003877	PF00622
363	376	Domain	Butyrophylin-like, SPRY domain	IPR003879	PR01407
407	431	Domain	Butyrophylin-like, SPRY domain	IPR003879	PR01407

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0010719	negative regulation of epithelial to mesenchymal transition	Biological Process	IEA	GO_REF:0000107
GO:0043123	positive regulation of canonical NF-kappaB signal transduction	Biological Process	IDA	PMID:11053425
GO:0002376	immune system process	Biological Process	IEA	GO_REF:0000043
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000041
GO:0019076	viral release from host cell	Biological Process	IMP	PMID:18248090
GO:0032897	negative regulation of viral transcription	Biological Process	IDA	PMID:18248090
GO:0044314	protein K27-linked ubiquitination	Biological Process	IDA	PMID:26488816
GO:0045087	innate immune response	Biological Process	IBA	GO_REF:0000033
GO:0045893	positive regulation of DNA-templated transcription	Biological Process	IEA	GO_REF:0000108
GO:0046596	regulation of viral entry into host cell	Biological Process	IDA	PMID:18248090
GO:1905036	positive regulation of antifungal innate immune response	Biological Process	IEA	GO_REF:0000120
GO:0005737	cytoplasm	Cellular Component	IBA	GO_REF:0000033
GO:0005829	cytosol	Cellular Component	TAS	Reactome:R-HSA-1031716
GO:0003713	transcription coactivator activity	Molecular Function	IDA	PMID:23077300
GO:0004842	ubiquitin-protein transferase activity	Molecular Function	IDA	PMID:23402750
GO:0005515	protein binding	Molecular Function	IPI	PMID:32296183
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000120
GO:0016740	transferase activity	Molecular Function	IEA	GO_REF:0000043
GO:0042802	identical protein binding	Molecular Function	IPI	PMID:32296183
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0061630	ubiquitin protein ligase activity	Molecular Function	IEA	GO_REF:0000003

Enzyme–Substrate Interactions ▾


Q9BVG3	TRI62	Yes	Yes	Yes	No	32296183	EBI-23370655	E3-specific
Q9H257	CARD9	Yes	Yes	No	No	—	No	E3-specific

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If you use or refer to the Database in your publications, reports, or presentations, you must cite the paper: Dutta et al. (2025, preprint)

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For inquiries, permissions, or support regarding the Database, please contact: Dr. Ramachandra M. Bhaskara, Goethe University Frankfurt.
Email: bhaskara@med.uni-frankfurt.de.
Website maintained by Alberto Cristiani, Arghya Dutta, and Siddhanta V. Nikte.

Substrate	Name	Known ESI (UbiBrowser)	Known ESI (UbiNet)	PPI (IntAct direct) PSI-MI score ≥ 0.5	PPI (IntAct indirect) PSI-MI scores ≥ 0.5 for both PPIs	PubMed Ref.	IntAct Ref.	Substrate Specificity
Q9BVG3	TRI62	Yes	Yes	Yes	No	32296183	EBI-23370655	E3-specific
Q9H257	CARD9	Yes	Yes	No	No	—	No	E3-specific