RN126

Details:

UniProt Entry: Q9BV68
Gene: RNF126
Class: RING
Family: RING4
Protein length: 311
Database confidence: 0.875
InterPro: InterPro Entry
Mode of Action: Standalone
AlphaFold Model: Link
PDB Structures: 2n9o, 2n9p

Protein Sequence ▾

>Q9BV68
MAEASPHPGR YFCHCCSVEI VPRLPDYICP RCESGFIEEL PEETRSTENG SAPSTAPTDQ
SRPPLEHVDQ HLFTLPQGYG QFAFGIFDDS FEIPTFPPGA QADDGRDPES RRERDHPSRH
RYGARQPRAR LTTRRATGRH EGVPTLEGII QQLVNGIITP ATIPSLGPWG VLHSNPMDYA
WGANGLDAII TQLLNQFENT GPPPADKEKI QALPTVPVTE EHVGSGLECP VCKDDYALGE
RVRQLPCNHL FHDGCIVPWL EQHDSCPVCR KSLTGQNTAT NPPGLTGVSF SSSSSSSSSS
SPSNENATSN S

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
10	40	Domain	E3 ubiquitin-protein ligase RNF126-like, zinc-ribbon	IPR039525	PF14369
215	289	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
228	271	Domain	RNF126, RING finger, H2 subclass	IPR039571	cd16801
228	270	Domain	Zinc finger, RING-type	IPR001841	PF13639
229	269	Domain	Zinc finger, RING-type	IPR001841	SM00184
229	270	Domain	Zinc finger, RING-type	IPR001841	PS50089

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0000209	protein polyubiquitination	Biological Process	IEA	GO_REF:0000117
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000041
GO:0000724	double-strand break repair via homologous recombination	Biological Process	IDA	PMID:29670289
GO:0110025	DNA strand resection involved in replication fork processing	Biological Process	IMP	PMID:26240375
GO:0006511	ubiquitin-dependent protein catabolic process	Biological Process	IMP	PMID:23026136
GO:0006513	protein monoubiquitination	Biological Process	IDA	PMID:23277564
GO:0035519	protein K29-linked ubiquitination	Biological Process	IDA	PMID:36563124
GO:0042059	negative regulation of epidermal growth factor receptor signaling pathway	Biological Process	IMP	PMID:23418353
GO:0042127	regulation of cell population proliferation	Biological Process	IMP	PMID:23026136
GO:0042147	retrograde transport, endosome to Golgi	Biological Process	IMP	PMID:24275455
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	Biological Process	IDA	PMID:24981174
GO:0043162	ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	Biological Process	IMP	PMID:23418353
GO:0044314	protein K27-linked ubiquitination	Biological Process	IDA	PMID:36563124
GO:0070534	protein K63-linked ubiquitination	Biological Process	ISS	GO_REF:0000024
GO:0070936	protein K48-linked ubiquitination	Biological Process	ISS	GO_REF:0000024
GO:0071629	cytoplasm protein quality control by the ubiquitin-proteasome system	Biological Process	IMP	PMID:24981174
GO:1905168	positive regulation of double-strand break repair via homologous recombination	Biological Process	IDA	PMID:36563124
GO:0005634	nucleus	Cellular Component	IEA	GO_REF:0000120
GO:0005654	nucleoplasm	Cellular Component	IDA	GO_REF:0000052
GO:0005737	cytoplasm	Cellular Component	IEA	GO_REF:0000120
GO:0005829	cytosol	Cellular Component	IDA	GO_REF:0000052
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0016740	transferase activity	Molecular Function	IEA	GO_REF:0000043
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0061630	ubiquitin protein ligase activity	Molecular Function	IEA	GO_REF:0000120
GO:0005154	epidermal growth factor receptor binding	Molecular Function	IEA	GO_REF:0000107
GO:0005515	protein binding	Molecular Function	IPI	PMID:14667819

Enzyme–Substrate Interactions ▾


Q9GZX7	AICDA	Yes	Yes	No	No	—	No	E3-specific
P36888	FLT3	Yes	Yes	No	No	—	No	Cluster-specific

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Substrate	Name	Known ESI (UbiBrowser)	Known ESI (UbiNet)	PPI (IntAct direct) PSI-MI score ≥ 0.5	PPI (IntAct indirect) PSI-MI scores ≥ 0.5 for both PPIs	PubMed Ref.	IntAct Ref.	Substrate Specificity
Q9GZX7	AICDA	Yes	Yes	No	No	—	No	E3-specific
P36888	FLT3	Yes	Yes	No	No	—	No	Cluster-specific