TRAF4

Details:

UniProt Entry: Q9BUZ4
Gene: TRAF4
Class: RING
Family: RING1
Protein length: 470
Database confidence: 0.875
InterPro: InterPro Entry
Mode of Action: Complex
AlphaFold Model: Link
PDB Structures: 2eod, 2yuc, 3zjb, 4k8u, 4m4e, 5yc1

Protein Sequence ▾

>Q9BUZ4
MPGFDYKFLE KPKRRLLCPL CGKPMREPVQ VSTCGHRFCD TCLQEFLSEG VFKCPEDQLP
LDYAKIYPDP ELEVQVLGLP IRCIHSEEGC RWSGPLRHLQ GHLNTCSFNV IPCPNRCPMK
LSRRDLPAHL QHDCPKRRLK CEFCGCDFSG EAYESHEGMC PQESVYCENK CGARMMRRLL
AQHATSECPK RTQPCTYCTK EFVFDTIQSH QYQCPRLPVA CPNQCGVGTV AREDLPGHLK
DSCNTALVLC PFKDSGCKHR CPKLAMARHV EESVKPHLAM MCALVSRQRQ ELQELRRELE
ELSVGSDGVL IWKIGSYGRR LQEAKAKPNL ECFSPAFYTH KYGYKLQVSA FLNGNGSGEG
THLSLYIRVL PGAFDNLLEW PFARRVTFSL LDQSDPGLAK PQHVTETFHP DPNWKNFQKP
GTWRGSLDES SLGFGYPKFI SHQDIRKRNY VRDDAVFIRA AVELPRKILS

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
1	470	Family	TNF receptor-associated factor TRAF, metazoa	IPR012227	PIRSF015614
4	76	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
18	58	Domain	Zinc finger, RING-type	IPR001841	PS50089
18	57	Domain	Zinc finger, RING-type	IPR001841	SM00184
18	55	Domain	Zinc finger, C3HC4 RING-type	IPR018957	PF00097
34	43	Conserved_site	Zinc finger, RING-type, conserved site	IPR017907	PS00518
80	134	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
102	154	Domain	Zinc finger, TRAF-type	IPR001293	PS50145
102	156	Domain	Zinc finger, TRAF-type	IPR001293	PF02176
135	187	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
155	208	Domain	Zinc finger, TRAF-type	IPR001293	PS50145
188	248	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
209	266	Domain	Zinc finger, TRAF-type	IPR001293	PS50145
210	269	Domain	Zinc finger, TRAF-type	IPR001293	PF02176
282	470	Homologous_superfamily	TRAF-like	IPR008974	G3DSA:2.60.210.10
307	462	Domain	MATH/TRAF domain	IPR002083	PS50144
308	463	Domain	TNF receptor-associated factor 4, MATH domain	IPR037307	cd03781
312	445	Domain	MATH/TRAF domain	IPR002083	SM00061

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0007165	signal transduction	Biological Process	IEA	GO_REF:0000002
GO:0042981	regulation of apoptotic process	Biological Process	IEA	GO_REF:0000002
GO:0007585	respiratory gaseous exchange by respiratory system	Biological Process	IEA	GO_REF:0000107
GO:0030323	respiratory tube development	Biological Process	IEA	GO_REF:0000107
GO:0002376	immune system process	Biological Process	IEA	GO_REF:0000043
GO:0006915	apoptotic process	Biological Process	IEA	GO_REF:0000043
GO:0007166	cell surface receptor signaling pathway	Biological Process	IBA	GO_REF:0000033
GO:0043122	regulation of canonical NF-kappaB signal transduction	Biological Process	IBA	GO_REF:0000033
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	Biological Process	IEA	GO_REF:0000041
GO:0045087	innate immune response	Biological Process	IEA	GO_REF:0000043
GO:0045860	positive regulation of protein kinase activity	Biological Process	IDA	PMID:16157600
GO:0046330	positive regulation of JNK cascade	Biological Process	IEA	GO_REF:0000002
GO:0001650	fibrillar center	Cellular Component	IDA	GO_REF:0000052
GO:0005654	nucleoplasm	Cellular Component	IDA	GO_REF:0000052
GO:0005737	cytoplasm	Cellular Component	IEA	GO_REF:0000120
GO:0005829	cytosol	Cellular Component	IDA	GO_REF:0000052
GO:0005634	nucleus	Cellular Component	IEA	GO_REF:0000120
GO:0005856	cytoskeleton	Cellular Component	IEA	GO_REF:0000120
GO:0005886	plasma membrane	Cellular Component	IEA	GO_REF:0000120
GO:0005923	bicellular tight junction	Cellular Component	IEA	GO_REF:0000120
GO:0016020	membrane	Cellular Component	IEA	GO_REF:0000043
GO:0048471	perinuclear region of cytoplasm	Cellular Component	IEA	GO_REF:0000044
GO:0070161	anchoring junction	Cellular Component	IEA	GO_REF:0000043
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000120
GO:0019899	enzyme binding	Molecular Function	IEA	GO_REF:0000117
GO:0042802	identical protein binding	Molecular Function	IEA	GO_REF:0000117
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000120
GO:0005164	tumor necrosis factor receptor binding	Molecular Function	IEA	GO_REF:0000104
GO:0005515	protein binding	Molecular Function	IPI	PMID:10514511
GO:0016740	transferase activity	Molecular Function	IEA	GO_REF:0000043
GO:0019901	protein kinase binding	Molecular Function	IEA	GO_REF:0000107
GO:0031625	ubiquitin protein ligase binding	Molecular Function	IPI	PMID:11279055
GO:0031996	thioesterase binding	Molecular Function	IPI	PMID:11279055
GO:0035591	signaling adaptor activity	Molecular Function	IBA	GO_REF:0000033
GO:0050699	WW domain binding	Molecular Function	IPI	PMID:19937093

Enzyme–Substrate Interactions ▾

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