PHF23

Details:

UniProt Entry: Q9BUL5
Gene: PHF23
Class: RING
Family: RING1
Protein length: 403
Database confidence: 0.125
InterPro: InterPro Entry
Mode of Action: Unclassified
AlphaFold Model: Link
PDB Structures: 6wxk

Protein Sequence ▾

>Q9BUL5
MLEAMAEPSP EDPPPTLKPE TQPPEKRRRT IEDFNKFCSF VLAYAGYIPP SKEESDWPAS
GSSSPLRGES AADSDGWDSA PSDLRTIQTF VKKAKSSKRR AAQAGPTQPG PPRSTFSRLQ
APDSATLLEK MKLKDSLFDL DGPKVASPLS PTSLTHTSRP PAALTPVPLS QGDLSHPPRK
KDRKNRKLGP GAGAGFGVLR RPRPTPGDGE KRSRIKKSKK RKLKKAERGD RLPPPGPPQA
PPSDTDSEEE EEEEEEEEEE EMATVVGGEA PVPVLPTPPE APRPPATVHP EGVPPADSES
KEVGSTETSQ DGDASSSEGE MRVMDEDIMV ESGDDSWDLI TCYCRKPFAG RPMIECSLCG
TWIHLSCAKI KKTNVPDFFY CQKCKELRPE ARRLGGPPKS GEP

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
332	392	Homologous_superfamily	Zinc finger, FYVE/PHD-type	IPR011011	SSF57903
336	386	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
341	385	Domain	Zinc finger, PHD-type	IPR001965	SM00249
342	386	Domain	Zinc finger, PHD-finger	IPR019787	PF00628

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0006914	autophagy	Biological Process	IEA	GO_REF:0000043
GO:0031398	positive regulation of protein ubiquitination	Biological Process	IBA	GO_REF:0000033
GO:1901097	negative regulation of autophagosome maturation	Biological Process	IBA	GO_REF:0000033
GO:1902902	negative regulation of autophagosome assembly	Biological Process	IBA	GO_REF:0000033
GO:0005634	nucleus	Cellular Component	IEA	GO_REF:0000044
GO:0005654	nucleoplasm	Cellular Component	IDA	GO_REF:0000052
GO:0005829	cytosol	Cellular Component	IDA	GO_REF:0000052
GO:0005737	cytoplasm	Cellular Component	IEA	GO_REF:0000120
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0005515	protein binding	Molecular Function	IPI	PMID:25484098

Enzyme–Substrate Interactions ▾

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