PCGF1

Details:

UniProt Entry: Q9BSM1
Gene: PCGF1
Class: RING
Family: RING4
Protein length: 259
Database confidence: 0.875
InterPro: InterPro Entry
Mode of Action: Complex
AlphaFold Model: Link
PDB Structures: 4hpl, 4hpm, 5jh5

Protein Sequence ▾

>Q9BSM1
MASPQGGQIA IAMRLRNQLQ SVYKMDPLRN EEEVRVKIKD LNEHIVCCLC AGYFVDATTI
TECLHTFCKS CIVKYLQTSK YCPMCNIKIH ETQPLLNLKL DRVMQDIVYK LVPGLQDSEE
KRIREFYQSR GLDRVTQPTG EEPALSNLGL PFSSFDHSKA HYYRYDEQLN LCLERLSSGK
DKNKSVLQNK YVRCSVRAEV RHLRRVLCHR LMLNPQHVQL LFDNEVLPDH MTMKQIWLSR
WFGKPSPLLL QYSVKEKRR

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
31	136	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
47	86	Domain	Zinc finger, RING-type	IPR001841	PS50089
47	85	Domain	Zinc finger, RING-type	IPR001841	SM00184
63	72	Conserved_site	Zinc finger, RING-type, conserved site	IPR017907	PS00518
190	253	Domain	RAWUL domain	IPR032443	PF16207

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0000122	negative regulation of transcription by RNA polymerase II	Biological Process	IBA	GO_REF:0000033
GO:0006338	chromatin remodeling	Biological Process	IDA	PMID:16943429
GO:0006355	regulation of DNA-templated transcription	Biological Process	TAS	PMID:26687479
GO:0005634	nucleus	Cellular Component	IEA	GO_REF:0000120
GO:0005654	nucleoplasm	Cellular Component	IDA	GO_REF:0000052
GO:0031519	PcG protein complex	Cellular Component	IEA	GO_REF:0000120
GO:0035102	PRC1 complex	Cellular Component	IBA	GO_REF:0000033
GO:0005515	protein binding	Molecular Function	IPI	PMID:16943429
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:1990841	promoter-specific chromatin binding	Molecular Function	IBA	GO_REF:0000033

Enzyme–Substrate Interactions ▾

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