TRI56

Details:

UniProt Entry: Q9BRZ2
Gene: TRIM56
Class: RING
Family: RING8
Protein length: 755
Database confidence: 1.0
InterPro: InterPro Entry
Mode of Action: Standalone
AlphaFold Model: Link
PDB Structures: 5jw7

Protein Sequence ▾

>Q9BRZ2
MVSHGSSPSL LEALSSDFLA CKICLEQLRA PKTLPCLHTY CQDCLAQLAD GGRVRCPECR
ETVPVPPEGV ASFKTNFFVN GLLDLVKARA CGDLRAGKPA CALCPLVGGT STGGPATARC
LDCADDLCQA CADGHRCTRQ THTHRVVDLV GYRAGWYDEE ARERQAAQCP QHPGEALRFL
CQPCSQLLCR ECRLDPHLDH PCLPLAEAVR ARRPGLEGLL AGVDNNLVEL EAARRVEKEA
LARLREQAAR VGTQVEEAAE GVLRALLAQK QEVLGQLRAH VEAAEEAARE RLAELEGREQ
VARAAAAFAR RVLSLGREAE ILSLEGAIAQ RLRQLQGCPW APGPAPCLLP QLELHPGLLD
KNCHLLRLSF EEQQPQKDGG KDGAGTQGGE ESQSRREDEP KTERQGGVQP QAGDGAQTPK
EEKAQTTREE GAQTLEEDRA QTPHEDGGPQ PHRGGRPNKK KKFKGRLKSI SREPSPALGP
NLDGSGLLPR PIFYCSFPTR MPGDKRSPRI TGLCPFGPRE ILVADEQNRA LKRFSLNGDY
KGTVPVPEGC SPCSVAALQS AVAFSASARL YLINPNGEVQ WRRALSLSQA SHAVAALPSG
DRVAVSVAGH VEVYNMEGSL ATRFIPGGKA SRGLRALVFL TTSPQGHFVG SDWQQNSVVI
CDGLGQVVGE YKGPGLHGCQ PGSVSVDKKG YIFLTLREVN KVVILDPKGS LLGDFLTAYH
GLEKPRVTTM VDGRYLVVSL SNGTIHIFRV RSPDS

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
12	91	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
21	59	Domain	Zinc finger, RING-type	IPR001841	SM00184
21	57	Domain	Zinc finger, RING-type, eukaryotic	IPR027370	PF13445
21	60	Domain	Zinc finger, RING-type	IPR001841	PS50089
36	45	Conserved_site	Zinc finger, RING-type, conserved site	IPR017907	PS00518
164	205	Domain	B-box-type zinc finger	IPR000315	PS50119
164	205	Domain	B-box-type zinc finger	IPR000315	SM00336
165	205	Domain	B-box-type zinc finger	IPR000315	PF00643
492	753	Homologous_superfamily	Six-bladed beta-propeller, TolB-like	IPR011042	G3DSA:2.120.10.30

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0140896	cGAS/STING signaling pathway	Biological Process	IDA	PMID:32911482
GO:0002376	immune system process	Biological Process	IEA	GO_REF:0000043
GO:0006513	protein monoubiquitination	Biological Process	IEA	GO_REF:0000117
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000041
GO:0032479	regulation of type I interferon production	Biological Process	IEA	GO_REF:0000117
GO:0032728	positive regulation of interferon-beta production	Biological Process	ISS	GO_REF:0000024
GO:0034340	response to type I interferon	Biological Process	ISS	GO_REF:0000024
GO:0045087	innate immune response	Biological Process	IBA	GO_REF:0000033
GO:0045089	positive regulation of innate immune response	Biological Process	IDA	PMID:29426904
GO:0051607	defense response to virus	Biological Process	ISS	GO_REF:0000024
GO:0060340	positive regulation of type I interferon-mediated signaling pathway	Biological Process	IBA	GO_REF:0000033
GO:0070534	protein K63-linked ubiquitination	Biological Process	ISS	GO_REF:0000024
GO:1901224	positive regulation of non-canonical NF-kappaB signal transduction	Biological Process	IDA	PMID:35952808
GO:0005654	nucleoplasm	Cellular Component	IBA	GO_REF:0000033
GO:0005737	cytoplasm	Cellular Component	ISS	GO_REF:0000024
GO:0005829	cytosol	Cellular Component	TAS	Reactome:R-HSA-1964496
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0003723	RNA binding	Molecular Function	HDA	PMID:22658674
GO:0004842	ubiquitin-protein transferase activity	Molecular Function	TAS	Reactome:R-HSA-3134804
GO:0005515	protein binding	Molecular Function	IPI	PMID:22948160
GO:0016740	transferase activity	Molecular Function	IEA	GO_REF:0000043
GO:0061630	ubiquitin protein ligase activity	Molecular Function	ISS	GO_REF:0000024

Enzyme–Substrate Interactions ▾


O00422	SAP18	Yes	No	No	No	—	No	E3-specific

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