KLDC3

Details:

UniProt Entry: Q9BQ90
Gene: KLHDC3
Class: Other E3 Components
Family: Receptor
Protein length: 382
Database confidence: 0.375
InterPro: InterPro Entry
Mode of Action: unknown
AlphaFold Model: Link

Protein Sequence ▾

>Q9BQ90
MLRWTVHLEG GPRRVNHAAV AVGHRVYSFG GYCSGEDYET LRQIDVHIFN AVSLRWTKLP
PVKSAIRGQA PVVPYMRYGH STVLIDDTVL LWGGRNDTEG ACNVLYAFDV NTHKWFTPRV
SGTVPGARDG HSACVLGKIM YIFGGYEQQA DCFSNDIHKL DTSTMTWTLI CTKGSPARWR
DFHSATMLGS HMYVFGGRAD RFGPFHSNNE IYCNRIRVFD TRTEAWLDCP PTPVLPEGRR
SHSAFGYNGE LYIFGGYNAR LNRHFHDLWK FNPVSFTWKK IEPKGKGPCP RRRQCCCIVG
DKIVLFGGTS PSPEEGLGDE FDLIDHSDLH ILDFSPSLKT LCKLAVIQYN LDQSCLPHDI
RWELNAMTTN SNISRPIVSS HG

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
2	168	Homologous_superfamily	Kelch-type beta propeller	IPR015915	G3DSA:2.120.10.80
11	69	Homologous_superfamily	Kelch-type beta propeller	IPR015915	SSF117281
71	319	Homologous_superfamily	Kelch-type beta propeller	IPR015915	SSF117281
127	174	Repeat	Kelch repeat type 2	IPR011498	PF07646
173	356	Homologous_superfamily	Kelch-type beta propeller	IPR015915	G3DSA:2.120.10.80
182	231	Repeat	Kelch repeat type 1	IPR006652	PF01344

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0007131	reciprocal meiotic recombination	Biological Process	NAS	PMID:12606021
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000041
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	Biological Process	IDA	PMID:26138980
GO:0051321	meiotic cell cycle	Biological Process	IEA	GO_REF:0000043
GO:0140627	ubiquitin-dependent protein catabolic process via the C-end degron rule pathway	Biological Process	IDA	PMID:29779948
GO:0005654	nucleoplasm	Cellular Component	IDA	GO_REF:0000052
GO:0005737	cytoplasm	Cellular Component	IBA	GO_REF:0000033
GO:0031462	Cul2-RING ubiquitin ligase complex	Cellular Component	IDA	PMID:26138980
GO:0000785	chromatin	Cellular Component	IEA	GO_REF:0000117
GO:0005829	cytosol	Cellular Component	TAS	Reactome:R-HSA-1791177
GO:0003682	chromatin binding	Molecular Function	IEA	GO_REF:0000002
GO:0005515	protein binding	Molecular Function	IPI	PMID:12482870
GO:1990756	ubiquitin-like ligase-substrate adaptor activity	Molecular Function	IDA	PMID:26138980

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