RNF5

Details:

UniProt Entry: Q99942
Gene: RNF5
Class: RING
Family: RING4
Protein length: 180
Database confidence: 1.0
InterPro: InterPro Entry
Mode of Action: Standalone
AlphaFold Model: Link

Protein Sequence ▾

>Q99942
MAAAEEEDGG PEGPNRERGG AGATFECNIC LETAREAVVS VCGHLYCWPC LHQWLETRPE
RQECPVCKAG ISREKVVPLY GRGSQKPQDP RLKTPPRPQG QRPAPESRGG FQPFGDTGGF
HFSFGVGAFP FGFFTTVFNA HEPFRRGTGV DLGQGHPASS WQDSLFLFLA IFFFFWLLSI

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
15	81	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
19	109	Family	E3 ubiquitin-protein ligase RNF5/RNF185-like	IPR045103	PTHR12313
27	68	Domain	Zinc finger, RING-type	IPR001841	PS50089
27	67	Domain	Zinc finger, RING-type	IPR001841	SM00184
42	51	Conserved_site	Zinc finger, RING-type, conserved site	IPR017907	PS00518

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0009617	response to bacterium	Biological Process	IEA	GO_REF:0000107
GO:0010507	negative regulation of autophagy	Biological Process	IEA	GO_REF:0000107
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000120
GO:0031648	protein destabilization	Biological Process	IEA	GO_REF:0000107
GO:2000785	regulation of autophagosome assembly	Biological Process	IEA	GO_REF:0000107
GO:0006511	ubiquitin-dependent protein catabolic process	Biological Process	IEA	GO_REF:0000120
GO:0036503	ERAD pathway	Biological Process	IEA	GO_REF:0000117
GO:1904380	endoplasmic reticulum mannose trimming	Biological Process	IEA	GO_REF:0000117
GO:0030163	protein catabolic process	Biological Process	IMP	PMID:19285439
GO:0055085	transmembrane transport	Biological Process	TAS	Reactome:R-HSA-382556
GO:0070534	protein K63-linked ubiquitination	Biological Process	IDA	PMID:19269966
GO:0070936	protein K48-linked ubiquitination	Biological Process	IDA	PMID:19285439
GO:0005783	endoplasmic reticulum	Cellular Component	IDA	GO_REF:0000052
GO:0005789	endoplasmic reticulum membrane	Cellular Component	IEA	GO_REF:0000120
GO:0016020	membrane	Cellular Component	IEA	GO_REF:0000120
GO:0031966	mitochondrial membrane	Cellular Component	IEA	GO_REF:0000120
GO:0044322	endoplasmic reticulum quality control compartment	Cellular Component	IEA	GO_REF:0000108
GO:0005739	mitochondrion	Cellular Component	IEA	GO_REF:0000043
GO:0005886	plasma membrane	Cellular Component	IEA	GO_REF:0000120
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0016740	transferase activity	Molecular Function	IEA	GO_REF:0000043
GO:0044390	ubiquitin-like protein conjugating enzyme binding	Molecular Function	IEA	GO_REF:0000104
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000120
GO:0061630	ubiquitin protein ligase activity	Molecular Function	IEA	GO_REF:0000120
GO:0004842	ubiquitin-protein transferase activity	Molecular Function	IDA	PMID:19269966
GO:0005515	protein binding	Molecular Function	IPI	PMID:12861019
GO:0042802	identical protein binding	Molecular Function	IPI	PMID:25416956
GO:0044877	protein-containing complex binding	Molecular Function	IPI	PMID:24019521

Enzyme–Substrate Interactions ▾


Q9P055	JKAMP	Yes	Yes	No	No	—	No	E3-specific
P49023	PAXI	Yes	Yes	Yes	No	12861019	EBI-963436	E3-specific
Q12770	SCAP	Yes	No	No	No	—	No	E3-specific
P68036	UB2L3	Yes	Yes	No	No	—	No	E3-specific
O43511	S26A4	Yes	Yes	No	No	—	No	E3-specific

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The E3 Ligome database, including all associated data, metadata, and documentation, is the intellectual property of Goethe University (PROXIDRUGs consortium) under the InnoDATA project.
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If you use or refer to the Database in your publications, reports, or presentations, you must cite the paper: Dutta, A., Cristiani, A., Nikte, S.V. et al. Multi-scale classification decodes the complexity of the human E3 ligome. Nat Commun 16, 11382 (2025).

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For inquiries, permissions, or support regarding the Database, please contact: Dr. Ramachandra M. Bhaskara, Goethe University Frankfurt.
Email: bhaskara@med.uni-frankfurt.de.
Website maintained by Alberto Cristiani, Arghya Dutta, and Siddhanta V. Nikte.