BARD1

Details:

UniProt Entry: Q99728

Gene: BARD1

Class: RING

Family: RING9

Protein length: 777

Database confidence: 0.875

InterPro: InterPro Entry

Mode of Action: Standalone

AlphaFold Model: Link

PDB Structures: 1jm7, 2nte, 2r1z, 3c5r, 3fa2, 6m14, 7e8i, 7jzv, 7lyb, 7lyc

Protein Sequence ▾

Domain Architecture (From InterPro) ▾

Protein functions ▾

Start	End	Type	Name	InterPro	Source
26	122	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
41	105	Domain	BARD1, Zinc finger, RING-type	IPR039503	PF14835
47	91	Domain	BARD1, Zinc finger, RING-type	IPR039503	cd16496
50	86	Domain	Zinc finger, RING-type	IPR001841	PS50089
66	75	Conserved_site	Zinc finger, RING-type, conserved site	IPR017907	PS00518
420	555	Homologous_superfamily	Ankyrin repeat-containing domain superfamily	IPR036770	G3DSA:1.25.40.20
423	533	Homologous_superfamily	Ankyrin repeat-containing domain superfamily	IPR036770	SSF48403
427	459	Repeat	Ankyrin repeat	IPR002110	PS50088
427	456	Repeat	Ankyrin repeat	IPR002110	SM00248
432	521	Repeat	Ankyrin repeat	IPR002110	PF12796
460	489	Repeat	Ankyrin repeat	IPR002110	SM00248
460	492	Repeat	Ankyrin repeat	IPR002110	PS50088
461	476	Repeat	Ankyrin repeat	IPR002110	PR01415
493	525	Repeat	Ankyrin repeat	IPR002110	PS50088
493	522	Repeat	Ankyrin repeat	IPR002110	SM00248
509	523	Repeat	Ankyrin repeat	IPR002110	PR01415
560	643	Domain	BRCT domain	IPR001357	SM00292
568	667	Homologous_superfamily	BRCT domain superfamily	IPR036420	G3DSA:3.40.50.10190
569	669	Homologous_superfamily	BRCT domain superfamily	IPR036420	SSF52113
570	653	Domain	BRCT domain	IPR001357	PS50172
616	776	Homologous_superfamily	BRCT domain superfamily	IPR036420	SSF52113
667	777	Domain	BRCT domain	IPR001357	PS50172
668	771	Homologous_superfamily	BRCT domain superfamily	IPR036420	G3DSA:3.40.50.10190
669	770	Domain	BRCT domain	IPR001357	SM00292

GO term	Name	Ontology	Evidence	Reference
GO:0006281	DNA repair	Biological Process	IEA	GO_REF:0000043
GO:0006974	DNA damage response	Biological Process	IEA	GO_REF:0000043
GO:0001894	tissue homeostasis	Biological Process	TAS	PMID:15782130
GO:0006282	regulation of DNA repair	Biological Process	NAS	PMID:20656689
GO:0006338	chromatin remodeling	Biological Process	TAS	PMID:35351360
GO:0006357	regulation of transcription by RNA polymerase II	Biological Process	TAS	PMID:35351360
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000041
GO:0031441	negative regulation of mRNA 3'-end processing	Biological Process	NAS	PMID:15905410
GO:0035825	homologous recombination	Biological Process	NAS	PMID:22369660
GO:0042325	regulation of phosphorylation	Biological Process	IMP	PMID:15782130
GO:0043065	positive regulation of apoptotic process	Biological Process	IMP	PMID:15782130
GO:0043066	negative regulation of apoptotic process	Biological Process	IMP	PMID:15265711
GO:0044818	mitotic G2/M transition checkpoint	Biological Process	NAS	PMID:22369660
GO:0045732	positive regulation of protein catabolic process	Biological Process	NAS	PMID:15905410
GO:0045786	negative regulation of cell cycle	Biological Process	NAS	PMID:15159397
GO:0046826	negative regulation of protein export from nucleus	Biological Process	IDA	PMID:15265711
GO:0051726	regulation of cell cycle	Biological Process	NAS	PMID:15632137
GO:0071479	cellular response to ionizing radiation	Biological Process	IMP	PMID:14636569
GO:0085020	protein K6-linked ubiquitination	Biological Process	IBA	GO_REF:0000033
GO:0110025	DNA strand resection involved in replication fork processing	Biological Process	NAS	PMID:29709199
GO:2000001	regulation of DNA damage checkpoint	Biological Process	NAS	PMID:14636569
GO:0005654	nucleoplasm	Cellular Component	IEA	GO_REF:0000117
GO:0005634	nucleus	Cellular Component	IEA	GO_REF:0000120
GO:0016607	nuclear speck	Cellular Component	IDA	GO_REF:0000052
GO:0036464	cytoplasmic ribonucleoprotein granule	Cellular Component	IDA	GO_REF:0000052
GO:0005737	cytoplasm	Cellular Component	IDA	PMID:15265711
GO:0000151	ubiquitin ligase complex	Cellular Component	NAS	PMID:14976165
GO:0000152	nuclear ubiquitin ligase complex	Cellular Component	IDA	PMID:14636569
GO:0031436	BRCA1-BARD1 complex	Cellular Component	IBA	GO_REF:0000033
GO:0070531	BRCA1-A complex	Cellular Component	IBA	GO_REF:0000033
GO:0070532	BRCA1-B complex	Cellular Component	IPI	PMID:16391231
GO:0070533	BRCA1-C complex	Cellular Component	IPI	PMID:16391231
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0016740	transferase activity	Molecular Function	IEA	GO_REF:0000043
GO:0005515	protein binding	Molecular Function	IPI	PMID:25416956
GO:0004842	ubiquitin-protein transferase activity	Molecular Function	IBA	GO_REF:0000033
GO:0003723	RNA binding	Molecular Function	IDA	PMID:12419249
GO:0019900	kinase binding	Molecular Function	NAS	PMID:15782130
GO:0042803	protein homodimerization activity	Molecular Function	IPI	PMID:15265711
GO:0046982	protein heterodimerization activity	Molecular Function	IPI	PMID:15265711
GO:0061630	ubiquitin protein ligase activity	Molecular Function	IEA	GO_REF:0000003
GO:0061649	ubiquitin-modified histone reader activity	Molecular Function	TAS	PMID:35351360
GO:0140863	histone H2AK127 ubiquitin ligase activity	Molecular Function	TAS	PMID:35351360
GO:0140864	histone H2AK129 ubiquitin ligase activity	Molecular Function	TAS	PMID:35351360

Enzyme–Substrate Interactions ▾

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