SPSB2

>Q99619
MGQTALAGGS SSTPTPQALY PDLSCPEGLE ELLSAPPPDL GAQRRHGWNP KDCSENIEVK
EGGLYFERRP VAQSTDGARG KRGYSRGLHA WEISWPLEQR GTHAVVGVAT ALAPLQTDHY
AALLGSNSES WGWDIGRGKL YHQSKGPGAP QYPAGTQGEQ LEVPERLLVV LDMEEGTLGY
AIGGTYLGPA FRGLKGRTLY PAVSAVWGQC QVRIRYLGER RAEPHSLLHL SRLCVRHNLG
DTRLGQVSAL PLPPAMKRYL LYQ

The same domains may appear in multiple rows, following InterPro convention.

Start	End	Type	Name	InterPro	Source
15	218	Homologous_superfamily	Concanavalin A-like lectin/glucanase domain superfamily	IPR013320	SSF49899
26	221	Domain	B30.2/SPRY domain	IPR001870	PS50188
43	227	Homologous_superfamily	B30.2/SPRY domain superfamily	IPR043136	G3DSA:2.60.120.920
86	220	Domain	SPRY domain	IPR003877	SM00449
89	214	Domain	SPRY domain	IPR003877	PF00622
211	263	Domain	SOCS box domain	IPR001496	PS50225
218	263	Domain	SOCS box domain	IPR001496	SM00253
221	262	Homologous_superfamily	SOCS box-like domain superfamily	IPR036036	SSF158235
222	263	Domain	SSB2, SOCS box domain	IPR037340	cd03719
223	261	Domain	SOCS box domain	IPR001496	PF07525
224	263	Domain	SOCS box domain	IPR001496	SM00969

GO term	Name	Ontology	Evidence	Reference
GO:0006511	ubiquitin-dependent protein catabolic process	Biological Process	IEA	GO_REF:0000120
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000120
GO:0035556	intracellular signal transduction	Biological Process	IEA	GO_REF:0000002
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	Biological Process	IBA	GO_REF:0000033
GO:0005737	cytoplasm	Cellular Component	IEA	GO_REF:0000120
GO:0005829	cytosol	Cellular Component	IEA	GO_REF:0000120
GO:0019005	SCF ubiquitin ligase complex	Cellular Component	IBA	GO_REF:0000033
GO:0005515	protein binding	Molecular Function	IPI	PMID:15601820
GO:1990756	ubiquitin-like ligase-substrate adaptor activity	Molecular Function	IEA	GO_REF:0000117

Type	ChEMBL Compound ID	Source	pChEMBL	PDB Compound ID	PDB Codes	SMILES
E3 Binder	CHEMBL3326273	ChEMBL	8.36	—	—	CC[C@H](C)[C@@H]1NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(C)=O)CSSC[C@H](C(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC1=O
E3 Binder	CHEMBL3326275	ChEMBL	7.46	—	—	CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CS)NC(C)=O)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(N)=O
E3 Binder	CHEMBL3326274	ChEMBL	6.5	—	—	CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(C)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(N)=O)C(N)=O