ZBT18

Details:

UniProt Entry: Q99592
Gene: ZBTB18
Class: RING
Family: RING6
Protein length: 522
Database confidence: 0.25
InterPro: InterPro Entry
Mode of Action: Unclassified
AlphaFold Model: Link

Protein Sequence ▾

>Q99592
MEFPDHSRHL LQCLSEQRHQ GFLCDCTVLV GDAQFRAHRA VLASCSMYFH LFYKDQLDKR
DIVHLNSDIV TAPAFALLLE FMYEGKLQFK DLPIEDVLAA ASYLHMYDIV KVCKKKLKEK
ATTEADSTKK EEDASSCSDK VESLSDGSSH IAGDLPSDED EGEDEKLNIL PSKRDLAAEP
GNMWMRLPSD SAGIPQAGGE AEPHATAAGK TVASPCSSTE SLSQRSVTSV RDSADVDCVL
DLSVKSSLSG VENLNSSYFS SQDVLRSNLV QVKVEKEASC DESDVGTNDY DMEHSTVKES
VSTNNRVQYE PAHLAPLRED SVLRELDRED KASDDEMMTP ESERVQVEGG MESSLLPYVS
NILSPAGQIF MCPLCNKVFP SPHILQIHLS THFREQDGIR SKPAADVNVP TCSLCGKTFS
CMYTLKRHER THSGEKPYTC TQCGKSFQYS HNLSRHAVVH TREKPHACKW CERRFTQSGD
LYRHIRKFHC ELVNSLSVKS EALSLPTVRD WTLEDSSQEL WK

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
1	150	Homologous_superfamily	SKP1/BTB/POZ domain superfamily	IPR011333	G3DSA:3.30.710.10
2	119	Homologous_superfamily	SKP1/BTB/POZ domain superfamily	IPR011333	SSF54695
14	120	Domain	BTB/POZ domain	IPR000210	PF00651
24	121	Domain	BTB/POZ domain	IPR000210	SM00225
24	91	Domain	BTB/POZ domain	IPR000210	PS50097
368	396	Homologous_superfamily	Zinc finger C2H2 superfamily	IPR036236	SSF57667
370	392	Domain	Zinc finger C2H2-type	IPR013087	SM00355
370	392	Domain	Zinc finger C2H2-type	IPR013087	PF00096
370	397	Domain	Zinc finger C2H2-type	IPR013087	PS50157
372	392	Domain	Zinc finger C2H2-type	IPR013087	PS00028
410	432	Domain	Zinc finger C2H2-type	IPR013087	SM00355
410	437	Domain	Zinc finger C2H2-type	IPR013087	PS50157
411	441	Homologous_superfamily	Zinc finger C2H2 superfamily	IPR036236	SSF57667
412	432	Domain	Zinc finger C2H2-type	IPR013087	PS00028
432	484	Homologous_superfamily	Zinc finger C2H2 superfamily	IPR036236	SSF57667
438	460	Domain	Zinc finger C2H2-type	IPR013087	PF00096
438	465	Domain	Zinc finger C2H2-type	IPR013087	PS50157
438	460	Domain	Zinc finger C2H2-type	IPR013087	SM00355
440	460	Domain	Zinc finger C2H2-type	IPR013087	PS00028
466	489	Domain	Zinc finger C2H2-type	IPR013087	SM00355
466	489	Domain	Zinc finger C2H2-type	IPR013087	PF00096
466	489	Domain	Zinc finger C2H2-type	IPR013087	PS50157
468	489	Domain	Zinc finger C2H2-type	IPR013087	PS00028

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0000122	negative regulation of transcription by RNA polymerase II	Biological Process	ISS	GO_REF:0000024
GO:0006357	regulation of transcription by RNA polymerase II	Biological Process	IBA	GO_REF:0000033
GO:0007519	skeletal muscle tissue development	Biological Process	ISS	GO_REF:0000024
GO:0045892	negative regulation of DNA-templated transcription	Biological Process	ISS	GO_REF:0000024
GO:0045944	positive regulation of transcription by RNA polymerase II	Biological Process	IDA	PMID:25796446
GO:0005634	nucleus	Cellular Component	IEA	GO_REF:0000043
GO:0000792	heterochromatin	Cellular Component	IDA	PMID:9756912
GO:0005654	nucleoplasm	Cellular Component	IDA	GO_REF:0000052
GO:0016607	nuclear speck	Cellular Component	IDA	GO_REF:0000052
GO:0003677	DNA binding	Molecular Function	IEA	GO_REF:0000043
GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	Molecular Function	IBA	GO_REF:0000033
GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	Molecular Function	IDA	PMID:9756912
GO:0005515	protein binding	Molecular Function	IPI	PMID:24722188
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0043565	sequence-specific DNA binding	Molecular Function	IDA	PMID:9756912
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:1990837	sequence-specific double-stranded DNA binding	Molecular Function	IDA	PMID:28473536

Enzyme–Substrate Interactions ▾

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