RING2

Details:

UniProt Entry: Q99496
Gene: RNF2
Class: RING
Family: RING4
Protein length: 336
Database confidence: 1.0
InterPro: InterPro Entry
Mode of Action: Complex
AlphaFold Model: Link
PDB Structures: 2h0d, 3gs2, 3h8h, 3ixs, 3rpg, 4r8p, 4s3o, 6wi7, 6wi8, 7nd1

Protein Sequence ▾

>Q99496
MSQAVQTNGT QPLSKTWELS LYELQRTPQE AITDGLEIVV SPRSLHSELM CPICLDMLKN
TMTTKECLHR FCADCIITAL RSGNKECPTC RKKLVSKRSL RPDPNFDALI SKIYPSRDEY
EAHQERVLAR INKHNNQQAL SHSIEEGLKI QAMNRLQRGK KQQIENGSGA EDNGDSSHCS
NASTHSNQEA GPSNKRTKTS DDSGLELDNN NAAMAIDPVM DGASEIELVF RPHPTLMEKD
DSAQTRYIKT SGNATVDHLS KYLAVRLALE ELRSKGESNQ MNLDTASEKQ YTIYIATASG
QFTVLNGSFS LELVSEKYWK VNKPMELYYA PTKEHK

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
2	201	Family	E3 ubiquitin-protein ligase RING1/RING2	IPR043540	PTHR46076
44	114	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
51	90	Domain	Zinc finger, RING-type	IPR001841	SM00184
51	91	Domain	Zinc finger, RING-type	IPR001841	PS50089
67	76	Conserved_site	Zinc finger, RING-type, conserved site	IPR017907	PS00518
246	330	Domain	RAWUL domain	IPR032443	PF16207

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0000122	negative regulation of transcription by RNA polymerase II	Biological Process	IEA	GO_REF:0000107
GO:0000278	mitotic cell cycle	Biological Process	IEA	GO_REF:0000107
GO:0001702	gastrulation with mouth forming second	Biological Process	IEA	GO_REF:0000107
GO:0009948	anterior/posterior axis specification	Biological Process	IEA	GO_REF:0000107
GO:0010467	gene expression	Biological Process	IEA	GO_REF:0000107
GO:0006325	chromatin organization	Biological Process	IEA	GO_REF:0000107
GO:0006338	chromatin remodeling	Biological Process	IDA	PMID:16943429
GO:0007281	germ cell development	Biological Process	IEA	GO_REF:0000107
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000041
GO:0040029	epigenetic regulation of gene expression	Biological Process	IMP	PMID:33864376
GO:0043433	negative regulation of DNA-binding transcription factor activity	Biological Process	IMP	PMID:18629613
GO:0005737	cytoplasm	Cellular Component	ISS	GO_REF:0000024
GO:0000791	euchromatin	Cellular Component	IEA	GO_REF:0000107
GO:0000792	heterochromatin	Cellular Component	IEA	GO_REF:0000107
GO:0001739	sex chromatin	Cellular Component	IEA	GO_REF:0000107
GO:0005634	nucleus	Cellular Component	IEA	GO_REF:0000120
GO:0005654	nucleoplasm	Cellular Component	IDA	GO_REF:0000052
GO:0005694	chromosome	Cellular Component	IEA	GO_REF:0000120
GO:0016604	nuclear body	Cellular Component	IDA	GO_REF:0000052
GO:0000151	ubiquitin ligase complex	Cellular Component	IEA	GO_REF:0000002
GO:0031519	PcG protein complex	Cellular Component	IBA	GO_REF:0000033
GO:0035102	PRC1 complex	Cellular Component	IEA	GO_REF:0000120
GO:0071339	MLL1 complex	Cellular Component	IDA	PMID:15960975
GO:0004842	ubiquitin-protein transferase activity	Molecular Function	IDA	PMID:16714294
GO:0003682	chromatin binding	Molecular Function	IBA	GO_REF:0000033
GO:0005515	protein binding	Molecular Function	IPI	PMID:10369680
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0016740	transferase activity	Molecular Function	IEA	GO_REF:0000043
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0061630	ubiquitin protein ligase activity	Molecular Function	ISS	GO_REF:0000024
GO:0071535	RING-like zinc finger domain binding	Molecular Function	IPI	PMID:16714294
GO:0140862	histone H2AK119 ubiquitin ligase activity	Molecular Function	ISS	GO_REF:0000024

Enzyme–Substrate Interactions ▾

Substrate	Name	Known ESI (UbiBrowser)	Known ESI (UbiNet)	PPI (IntAct direct) PSI-MI score ≥ 0.5	PPI (IntAct indirect) PSI-MI scores ≥ 0.5 for both PPIs	PubMed Ref.	IntAct Ref.	Substrate Specificity
P23921	RIR1	Yes	Yes	No	No	—	No	Cluster-specific
Q9C0C7	AMRA1	Yes	Yes	No	No	—	No	E3-specific
Q99496	RING2	Yes	Yes	No	Yes	—	No	Cluster-specific
Q7L7L0	H2A3	Yes	Yes	No	No	—	No	Cluster-specific
Q8N488	RYBP	Yes	Yes	Yes	Yes	27705803, 32296183, 26496610, 28514442, 16943429, 20696397, 24981860, 34316702	EBI-3955724	E3-specific
A6NK89	RASFA	Yes	No	No	No	—	No	E3-specific
O75496	GEMI	Yes	Yes	No	No	—	No	Cluster-specific
Q93077	H2A1C	Yes	Yes	No	No	—	No	Cluster-specific
Q99878	H2A1J	Yes	Yes	No	No	—	No	Cluster-specific
P20671	H2A1D	Yes	Yes	No	No	—	No	Cluster-specific
Q96KK5	H2A1H	Yes	Yes	No	No	—	No	Cluster-specific

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