UHRF1

Details:

UniProt Entry: Q96T88
Gene: UHRF1
Class: RING
Family: RING7
Protein length: 793
Database confidence: 0.875
InterPro: InterPro Entry
Mode of Action: Standalone
AlphaFold Model: Link
PDB Structures: 2faz, 2l3r, 2lgg, 2lgk, 2lgl, 2pb7, 3ask, 3asl, 3bi7, 3clz, 3db3, 3db4, 3dwh, 3fl2, 3shb, 3sou, 3sow, 3sox, 3t6r, 3zvy, 3zvz, 4gy5, 4qqd, 5c6d, 5iay, 5xpi, 5yy9, 5yya, 6b9m, 6iiw, 6vcs, 6ved, 6vyj, 6w92, 7fb7

Protein Sequence ▾

>Q96T88
MWIQVRTMDG RQTHTVDSLS RLTKVEELRR KIQELFHVEP GLQRLFYRGK QMEDGHTLFD
YEVRLNDTIQ LLVRQSLVLP HSTKERDSEL SDTDSGCCLG QSESDKSSTH GEAAAETDSR
PADEDMWDET ELGLYKVNEY VDARDTNMGA WFEAQVVRVT RKAPSRDEPC SSTSRPALEE
DVIYHVKYDD YPENGVVQMN SRDVRARART IIKWQDLEVG QVVMLNYNPD NPKERGFWYD
AEISRKRETR TARELYANVV LGDDSLNDCR IIFVDEVFKI ERPGEGSPMV DNPMRRKSGP
SCKHCKDDVN RLCRVCACHL CGGRQDPDKQ LMCDECDMAF HIYCLDPPLS SVPSEDEWYC
PECRNDASEV VLAGERLRES KKKAKMASAT SSSQRDWGKG MACVGRTKEC TIVPSNHYGP
IPGIPVGTMW RFRVQVSESG VHRPHVAGIH GRSNDGAYSL VLAGGYEDDV DHGNFFTYTG
SGGRDLSGNK RTAEQSCDQK LTNTNRALAL NCFAPINDQE GAEAKDWRSG KPVRVVRNVK
GGKNSKYAPA EGNRYDGIYK VVKYWPEKGK SGFLVWRYLL RRDDDEPGPW TKEGKDRIKK
LGLTMQYPEG YLEALANRER EKENSKREEE EQQEGGFASP RTGKGKWKRK SAGGGPSRAG
SPRRTSKKTK VEPYSLTAQQ SSLIREDKSN AKLWNEVLAS LKDRPASGSP FQLFLSKVEE
TFQCICCQEL VFRPITTVCQ HNVCKDCLDR SFRAQVFSCP ACRYDLGRSY AMQVNQPLQT
VLNQLFPGYG NGR

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
1	75	Domain	Ubiquitin-like domain	IPR000626	PS50053
1	74	Domain	Ubiquitin-like domain	IPR000626	SM00213
1	96	Homologous_superfamily	Ubiquitin-like domain superfamily	IPR029071	SSF54236
3	75	Domain	Ubiquitin-like domain	IPR000626	PF00240
32	788	Family	UHRF1/2-like	IPR045134	PTHR14140
133	284	Domain	UHRF1, tandem tudor domain	IPR021991	PF12148
310	366	Domain	Zinc finger, PHD-finger	IPR019787	PS50016
316	367	Homologous_superfamily	Zinc finger, FYVE/PHD-type	IPR011011	SSF57903
317	364	Domain	Zinc finger, PHD-type	IPR001965	SM00249
318	365	Domain	Zinc finger, PHD-finger	IPR019787	PF00628
318	364	Domain	Zinc finger, RING-type	IPR001841	PS50089
318	363	Domain	Zinc finger, RING-type	IPR001841	SM00184
399	609	Homologous_superfamily	SRA-YDG superfamily	IPR036987	G3DSA:2.30.280.10
400	607	Homologous_superfamily	PUA-like superfamily	IPR015947	SSF88697
414	586	Domain	SRA-YDG	IPR003105	SM00466
417	585	Domain	SRA-YDG	IPR003105	PF02182
419	582	Domain	SRA-YDG	IPR003105	PS51015
670	793	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
724	762	Domain	Zinc finger, RING-type	IPR001841	SM00184
724	763	Domain	Zinc finger, RING-type	IPR001841	PS50089
739	748	Conserved_site	Zinc finger, RING-type, conserved site	IPR017907	PS00518

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0006325	chromatin organization	Biological Process	IEA	GO_REF:0000043
GO:0006950	response to stress	Biological Process	IEA	GO_REF:0000117
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000120
GO:0044027	negative regulation of gene expression via chromosomal CpG island methylation	Biological Process	IEA	GO_REF:0000117
GO:0051865	protein autoubiquitination	Biological Process	IEA	GO_REF:0000117
GO:0090307	mitotic spindle assembly	Biological Process	IDA	PMID:19001501
GO:0000122	negative regulation of transcription by RNA polymerase II	Biological Process	IEA	GO_REF:0000107
GO:0000724	double-strand break repair via homologous recombination	Biological Process	TAS	PMID:33939809
GO:0006281	DNA repair	Biological Process	IEA	GO_REF:0000043
GO:0006511	ubiquitin-dependent protein catabolic process	Biological Process	IDA	PMID:22945642
GO:0006974	DNA damage response	Biological Process	IEA	GO_REF:0000043
GO:0031507	heterochromatin formation	Biological Process	IDA	PMID:17967883
GO:0035825	homologous recombination	Biological Process	TAS	PMID:33939809
GO:0040029	epigenetic regulation of gene expression	Biological Process	TAS	PMID:33939809
GO:0045944	positive regulation of transcription by RNA polymerase II	Biological Process	IDA	PMID:10646863
GO:0050678	regulation of epithelial cell proliferation	Biological Process	IMP	PMID:15361834
GO:0051247	positive regulation of protein metabolic process	Biological Process	IDA	PMID:10646863
GO:0000792	heterochromatin	Cellular Component	IEA	GO_REF:0000117
GO:0005634	nucleus	Cellular Component	IEA	GO_REF:0000120
GO:0005654	nucleoplasm	Cellular Component	IDA	GO_REF:0000052
GO:0005819	spindle	Cellular Component	IC	PMID:37728657
GO:0000785	chromatin	Cellular Component	ISS	GO_REF:0000024
GO:0000791	euchromatin	Cellular Component	IDA	PMID:21777816
GO:0005657	replication fork	Cellular Component	IEA	GO_REF:0000107
GO:0016363	nuclear matrix	Cellular Component	ISS	GO_REF:0000024
GO:0003677	DNA binding	Molecular Function	IEA	GO_REF:0000043
GO:0004842	ubiquitin-protein transferase activity	Molecular Function	IEA	GO_REF:0000104
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0016740	transferase activity	Molecular Function	IEA	GO_REF:0000043
GO:0042393	histone binding	Molecular Function	IEA	GO_REF:0000104
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0061630	ubiquitin protein ligase activity	Molecular Function	IEA	GO_REF:0000120
GO:0000987	cis-regulatory region sequence-specific DNA binding	Molecular Function	IDA	PMID:10646863
GO:0003676	nucleic acid binding	Molecular Function	EXP	PMID:18772889
GO:0005515	protein binding	Molecular Function	IPI	PMID:15361834
GO:0008327	methyl-CpG binding	Molecular Function	IDA	PMID:15361834
GO:0042802	identical protein binding	Molecular Function	ISS	GO_REF:0000024
GO:0044729	hemi-methylated DNA-binding	Molecular Function	IEA	GO_REF:0000107
GO:0062072	histone H3K9me2/3 reader activity	Molecular Function	IEA	GO_REF:0000107
GO:0140612	DNA damage sensor activity	Molecular Function	TAS	PMID:33939809
GO:0141055	histone H3 ubiquitin ligase activity	Molecular Function	ISS	GO_REF:0000024

Enzyme–Substrate Interactions ▾


P26358	DNMT1	Yes	Yes	Yes	No	19798101, 17934516	EBI-1548967	E3-specific

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