RUFY1

Details:

UniProt Entry: Q96T51
Gene: RUFY1
Class: RING
Family: RING9
Protein length: 708
Database confidence: 0.125
InterPro: InterPro Entry
Mode of Action: Unclassified
AlphaFold Model: Link
PDB Structures: 2yqm, 2yw8

Protein Sequence ▾

>Q96T51
MADREGGCAA GRGRELEPEL EPGPGPGSAL EPGEEFEIVD RSQLPGPGDL RSATRPRAAE
GWSAPILTLA RRATGNLSAS CGSALRAAAG LGGGDSGDGT ARAASKCQMM EERANLMHMM
KLSIKVLLQS ALSLGRSLDA DHAPLQQFFV VMEHCLKHGL KVKKSFIGQN KSFFGPLELV
EKLCPEASDI ATSVRNLPEL KTAVGRGRAW LYLALMQKKL ADYLKVLIDN KHLLSEFYEP
EALMMEEEGM VIVGLLVGLN VLDANLCLKG EDLDSQVGVI DFSLYLKDVQ DLDGGKEHER
ITDVLDQKNY VEELNRHLSC TVGDLQTKID GLEKTNSKLQ EELSAATDRI CSLQEEQQQL
REQNELIRER SEKSVEITKQ DTKVELETYK QTRQGLDEMY SDVWKQLKEE KKVRLELEKE
LELQIGMKTE MEIAMKLLEK DTHEKQDTLV ALRQQLEEVK AINLQMFHKA QNAESSLQQK
NEAITSFEGK TNQVMSSMKQ MEERLQHSER ARQGAEERSH KLQQELGGRI GALQLQLSQL
HEQCSSLEKE LKSEKEQRQA LQRELQHEKD TSSLLRMELQ QVEGLKKELR ELQDEKAELQ
KICEEQEQAL QEMGLHLSQS KLKMEDIKEV NQALKGHAWL KDDEATHCRQ CEKEFSISRR
KHHCRNCGHI FCNTCSSNEL ALPSYPKPVR VCDSCHTLLL QRCSSTAS

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
103	281	Homologous_superfamily	RUN domain superfamily	IPR037213	G3DSA:1.20.58.900
109	275	Homologous_superfamily	RUN domain superfamily	IPR037213	SSF140741
139	271	Domain	RUN domain	IPR004012	PS50826
147	269	Domain	RUN domain	IPR004012	PF02759
207	269	Domain	RUN domain	IPR004012	SM00593
594	704	Homologous_superfamily	Zinc finger, FYVE/PHD-type	IPR011011	SSF57903
627	708	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
634	701	Domain	FYVE zinc finger	IPR000306	SM00064
638	698	Domain	FYVE zinc finger	IPR000306	PF01363
642	700	Domain	Zinc finger, FYVE-related	IPR017455	PS50178
648	696	Domain	Zinc finger, RING-type	IPR001841	PS50089

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0007264	small GTPase-mediated signal transduction	Biological Process	IEA	GO_REF:0000107
GO:0030100	regulation of endocytosis	Biological Process	IEA	GO_REF:0000120
GO:0034058	endosomal vesicle fusion	Biological Process	IDA	PMID:20534812
GO:0034498	early endosome to Golgi transport	Biological Process	IDA	PMID:36282215
GO:0006897	endocytosis	Biological Process	IEA	GO_REF:0000043
GO:0015031	protein transport	Biological Process	IBA	GO_REF:0000033
GO:0005829	cytosol	Cellular Component	IDA	GO_REF:0000052
GO:0016607	nuclear speck	Cellular Component	IDA	GO_REF:0000052
GO:0005737	cytoplasm	Cellular Component	IBA	GO_REF:0000033
GO:0031901	early endosome membrane	Cellular Component	IDA	PMID:20534812
GO:0005768	endosome	Cellular Component	IEA	GO_REF:0000043
GO:0016020	membrane	Cellular Component	IEA	GO_REF:0000043
GO:0005515	protein binding	Molecular Function	IPI	PMID:21988832
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0008289	lipid binding	Molecular Function	IEA	GO_REF:0000043
GO:0017124	SH3 domain binding	Molecular Function	IEA	GO_REF:0000117
GO:0030674	protein-macromolecule adaptor activity	Molecular Function	IDA	PMID:20534812
GO:0042169	SH2 domain binding	Molecular Function	IPI	PMID:11877430
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000120
GO:0042802	identical protein binding	Molecular Function	IPI	PMID:32296183

Enzyme–Substrate Interactions ▾

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