CRBN

Start	End	Type	Name	InterPro	Source
61	185	Homologous_superfamily	Lon protease, N-terminal domain superfamily	IPR046336	G3DSA:2.30.130.40
80	317	Domain	Lon protease, N-terminal domain	IPR003111	PF02190
80	317	Domain	Lon protease, N-terminal domain	IPR003111	SM00464
80	316	Homologous_superfamily	PUA-like superfamily	IPR015947	SSF88697
81	317	Domain	Lon protease, N-terminal domain	IPR003111	PS51787
318	426	Domain	CULT domain	IPR034750	PS51788
320	432	Domain	Yippee/Mis18/Cereblon	IPR004910	PF03226
321	422	Domain	CULT domain	IPR034750	cd15777

GO term	Name	Ontology	Evidence	Reference
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000041
GO:0030177	positive regulation of Wnt signaling pathway	Biological Process	IBA	GO_REF:0000033
GO:0031333	negative regulation of protein-containing complex assembly	Biological Process	IEA	GO_REF:0000107
GO:0031334	positive regulation of protein-containing complex assembly	Biological Process	IEA	GO_REF:0000107
GO:0034766	negative regulation of monoatomic ion transmembrane transport	Biological Process	IEA	GO_REF:0000107
GO:0035641	locomotory exploration behavior	Biological Process	IEA	GO_REF:0000107
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	Biological Process	IBA	GO_REF:0000033
GO:0060173	limb development	Biological Process	IBA	GO_REF:0000033
GO:0005634	nucleus	Cellular Component	IEA	GO_REF:0000120
GO:0005737	cytoplasm	Cellular Component	IEA	GO_REF:0000120
GO:0016020	membrane	Cellular Component	IEA	GO_REF:0000120
GO:0005829	cytosol	Cellular Component	TAS	Reactome:R-HSA-9681169
GO:0048471	perinuclear region of cytoplasm	Cellular Component	IEA	GO_REF:0000107
GO:0031464	Cul4A-RING E3 ubiquitin ligase complex	Cellular Component	IBA	GO_REF:0000033
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0005515	protein binding	Molecular Function	IPI	PMID:20223979
GO:0044325	transmembrane transporter binding	Molecular Function	IEA	GO_REF:0000107

Type	ChEMBL Compound ID	Source	pChEMBL	PDB Compound ID	PDB Codes	SMILES
E3 Binder	CHEMBL5266158	ChEMBL	8.0	—	—	C#C/C(=C\C(C)(C)CCCCOCCOCCOCCOCCOc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O)C(=O)N1CCCC(n2nc(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc32)C1
E3 Binder	CHEMBL4647144	ChEMBL	6.24	—	—	C#CCCCC(=O)N1CCN(c2cc(Nc3ncc(/C=C/c4ccc(F)c(F)c4)s3)nc(C)n2)CC1
E3 Binder	CHEMBL4649252	ChEMBL	6.35	—	—	C#CCCCC(=O)N1CCN(c2cc(Nc3ncc(/C=C/c4cccc(C)c4)s3)nc(C)n2)CC1
E3 Binder	CHEMBL4642122	ChEMBL	6.11	—	—	C#CCCCC(=O)N1CCN(c2cc(Nc3ncc(/C=C/c4cccc(F)c4)s3)nc(C)n2)CC1
E3 Binder	CHEMBL5271189	ChEMBL	7.89	—	—	CC(=O)C1=C(O)N(C2CCCC2)c2nc(Nc3ccc(N4CCN(Cc5cn(CCCCCNc6cccc7c6C(=O)N(C6CCC(=O)NC6=O)C7=O)nn5)CC4)cn3)ncc2C1C
E3 Binder	CHEMBL5172193	ChEMBL	8.49	—	—	CC(=O)Nc1cc(Nc2cccc3c2C(=O)N(C2CCC(=O)NC2=O)C3=O)cc(C(C)(C)C)c1
E3 Binder	CHEMBL5183717	ChEMBL	7.96	—	—	CC(=O)Nc1cc(Oc2cccc3c2C(=O)N(C2CCC(=O)NC2=O)C3=O)cc(C(C)(C)C)c1
E3 Binder	CHEMBL5201283	ChEMBL	7.85	—	—	CC(C)(C)c1cc(N)cc(Oc2cccc3c2C(=O)N(C2CCC(=O)NC2=O)C3=O)c1
E3 Binder	CHEMBL4645982	ChEMBL	10.0	—	—	CC(C)C1CCN(Cc2ccc(COc3cccc4c3CN(C3CCC(=O)NC3=O)C4=O)cc2)CC1
E3 Binder	CHEMBL4642197	ChEMBL	9.52	—	—	CC(C)N1CCN(Cc2ccc(COc3cccc4c3CN(C3CCC(=O)NC3=O)C4=O)cc2)CC1
E3 Binder	CHEMBL5204319	ChEMBL	7.34	—	—	CC1(C)CCC(c2ccccc2)=C(CN2CCN(c3ccc(C(=O)NS(=O)(=O)c4ccc(N[C@H](CCN5CCN(C(=O)CCCn6cc(COCCOCCNc7cccc8c7C(=O)N(C7CCC(=O)NC7=O)C8=O)nn6)CC5)CSc5ccccc5)c(S(=O)(=O)C(F)(F)F)c4)cc3)CC2)C1
E3 Binder	CHEMBL4646021	ChEMBL	9.52	—	—	CC1(C)CCN(Cc2ccc(COc3cccc4c3CN(C3CCC(=O)NC3=O)C4=O)cc2)CC1
E3 Binder	CHEMBL4643542	ChEMBL	9.0	—	—	CC1CCN(Cc2ccc(COc3cccc4c3CN(C3CCC(=O)NC3=O)C4=O)cc2)CC1
E3 Binder	CHEMBL4209505	ChEMBL	8.0	—	—	CCC(C)(C)C(=O)C(=O)N1CCCC[C@H]1C(=O)O[C@H](CCc1ccc(OC)c(OC)c1)c1cccc(NC(=O)CCC(=O)NCCNC(=O)COc2cccc3c2C(=O)N(C2CCC(=O)NC2=O)C3=O)c1
E3 Binder	CHEMBL4797017	ChEMBL	9.3	—	—	CCCn1cc(-c2nc(Nc3ccc(C(=O)NCCCCCNc4cccc5c4CN(C4CCC(=O)NC4=O)C5=O)cc3)nc3[nH]ccc23)cn1
E3 Binder	CHEMBL5178146	ChEMBL	7.22	—	—	CCN(c1cc(-c2ccc(CN3CCN(C(=O)CCCCCCCNc4cccc5c4C(=O)N(C4CCC(=O)NC4=O)C5=O)CC3)cc2)cc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C)C1CCOCC1
E3 Binder	CHEMBL5175736	ChEMBL	7.0	—	—	CCN(c1cc(-c2ccc(CN3CCN(C(=O)CCCCCNc4cccc5c4C(=O)N(C4CCC(=O)NC4=O)C5=O)CC3)cc2)cc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C)C1CCOCC1
E3 Binder	CHEMBL5273652	ChEMBL	7.01	—	—	CN(C)C(=O)c1cn(C2CCCC2)c2cnc(Nc3ccc(N4CCN(c5cn(CCCCCNc6cccc7c6C(=O)N(C6CCC(=O)NC6=O)C7=O)nn5)CC4)cn3)nc12
E3 Binder	CHEMBL5195741	ChEMBL	8.18	—	—	CN(CCCNC(=O)CNc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O)C(C)(C)C=C(C#N)C(=O)N1CCC[C@@H](n2nc(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc32)C1
E3 Binder	CHEMBL4645406	ChEMBL	6.01	—	—	CN(c1ccccc1)c1nccc(NCC(=O)Nc2cccc3c2CN(C2CCC(=O)NC2=O)C3=O)n1
E3 Binder	CHEMBL4642035	ChEMBL	8.52	—	—	CN1CCN(Cc2ccc(COc3cccc4c3CN(C3CCC(=O)NC3=O)C4=O)cc2)CC1
E3 Handle	—	PROTACDB3	6.0*	—	—	CN1CCN(c2ccc(NC3CCC(=O)NC3=O)cc2)CC1
E3 Handle	—	PROTACDB3	6.0*	—	—	CN1CCc2cc3c(cc2C1)C(=O)N(C1CCC(=O)NC1=O)C3=O
E3 Handle	—	PROTACDB3	6.0*	—	—	CN1CCc2cc3c(cc2CC1)C(=O)N(C1CCC(=O)NC1=O)C3=O
E3 Binder	CHEMBL4848064	ChEMBL	9.18	—	—	CNC(=O)N1N=C(c2ccc(N3CCN(C(=O)CCCCNC(=O)COc4cccc5c4C(=O)N(C4CCC(=O)NC4=O)C5=O)CC3)cc2)c2cc(OC)c(OC)cc2C[C@@H]1C
E3 Binder	CHEMBL5178566	ChEMBL	9.61	—	—	CNC(=O)N1N=C(c2ccc(N3CCN(C(=O)CCOCCOCCOCCNc4cccc5c4C(=O)N(C4CCC(=O)NC4=O)C5=O)CC3)cc2)c2cc(OC)c(OC)cc2C[C@@H]1C
E3 Binder	CHEMBL4854720	ChEMBL	8.85	—	—	CNC(=O)N1N=C(c2ccc(N3CCN(C(=O)COCCOCC(=O)Nc4cccc5c4C(=O)N(C4CCC(=O)NC4=O)C5=O)CC3)cc2)c2cc(OC)c(OC)cc2C[C@@H]1C
E3 Binder	CHEMBL4647512	ChEMBL	9.3	—	—	COc1ccc(N2CCN(Cc3ccc(COc4cccc5c4CN(C4CCC(=O)NC4=O)C5=O)cc3)CC2)cc1
E3 Binder	CHEMBL5208953	ChEMBL	7.82	—	—	COc1ccc(OC)c(-n2nnc(C(=O)Nc3cc(NC(=O)CNc4cccc5c4C(=O)N(C4CCC(=O)NC4=O)C5=O)cc(C(C)(C)C)c3)c2C)c1
E3 Binder	CHEMBL5193211	ChEMBL	6.39	—	—	COc1ccc(OC)c(-n2nnc(C(=O)Nc3cc(NC(=O)Nc4cccc5c4C(=O)N(C4CCC(=O)NC4=O)C5=O)cc(C(C)(C)C)c3)c2C)c1
E3 Binder	CHEMBL5174754	ChEMBL	7.62	—	—	COc1ccc(OC)c(-n2nnc(C(=O)Nc3cc(NCCNc4cccc5c4C(=O)N(C4CCC(=O)NC4=O)C5=O)cc(C(C)(C)C)c3)c2C)c1
E3 Binder	CHEMBL5205527	ChEMBL	7.77	—	—	COc1ccc(OC)c(-n2nnc(C(=O)Nc3cc(OC(=O)CNc4cccc5c4C(=O)N(C4CCC(=O)NC4=O)C5=O)cc(C(C)(C)C)c3)c2C)c1
E3 Binder	CHEMBL5182478	ChEMBL	7.64	—	—	COc1ccc(OC)c(-n2nnc(C(=O)Nc3cc(OCCNc4cccc5c4C(=O)N(C4CCC(=O)NC4=O)C5=O)cc(C(C)(C)C)c3)c2C)c1
E3 Binder	CHEMBL5172753	ChEMBL	7.51	—	—	COc1ccc(OC)c(-n2nnc(C(=O)Nc3cc(Oc4cccc5c4C(=O)N(C4CCC(=O)NC4=O)C5=O)cc(C(C)(C)C)c3)c2C)c1
E3 Handle	—	PROTACDB3	6.0*	—	—	COc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2
E3 Handle	—	PROTACDB3	6.0*	—	—	COc1ccccc1C(=O)NC1CCC(=O)NC1=O
E3 Handle	—	PROTACDB3	6.0*	—	—	COc1ccccc1N1CCC(=O)NC1=O
E3 Binder	CHEMBL5090015	ChEMBL	6.21	—	—	COc1ccccc1S(=O)(=O)Nc1ccc2c(c1)C(=O)N(C1CCC(=O)NC1=O)C2=O
E3 Binder	CHEMBL5278868	ChEMBL	8.7	—	—	C[C@@H]1C[C@@H](O)c2ncnc(N3CCN(C(=O)[C@H](CNCCCc4cccc5c4CN(C4CCC(=O)NC4=O)C5=O)c4ccc(Cl)cc4)CC3)c21
E3 Binder	CHEMBL5084741	ChEMBL	7.8	—	—	Cc1c(Cl)cccc1S(=O)(=O)Nc1ccc2c(c1)C(=O)N(C1CCC(=O)NC1=O)C2=O
E3 Binder	CHEMBL1171837	ChEMBL	7.97	0LI	—	Cc1ccc(C(=O)Nc2ccc(CN3CCN(C)CC3)c(C(F)(F)F)c2)cc1C#Cc1cnc2cccnn12
E3 Binder	CHEMBL4170596	ChEMBL	7.75	—	—	Cc1ccc(NC(=O)NCc2ccc3c(c2)CN(C2CCC(=O)NC2=O)C3=O)cc1Cl
E3 Binder	CHEMBL5084281	ChEMBL	9.0	—	—	Cc1ccc(S(=O)(=O)Nc2ccc3c(c2)C(=O)N(C2CCC(=O)NC2=O)C3=O)cc1Cl
E3 Binder	CHEMBL5073414	ChEMBL	7.96	—	—	Cc1ccccc1S(=O)(=O)Nc1ccc2c(c1)C(=O)N(C1CCC(=O)NC1=O)C2=O
E3 Binder	CHEMBL5277990	ChEMBL	6.37	—	—	Cc1sc2c(c1C)C(c1ccc(Cl)cc1)=N[C@@H](CC(=O)NCCCCNC(=O)COc1cccc3c1C(=O)N(C1CCC(=O)NC1=O)C3O)c1nnc(C)n1-2
E3 Binder	CHEMBL5287110	ChEMBL	6.37	—	—	Cc1sc2c(c1C)C(c1ccc(Cl)cc1)=N[C@@H](CC(=O)NCCCCNC(=O)Oc1cccc3c1C(=O)N(C1CCC(=O)NC1=O)C3=O)c1nnc(C)n1-2
E3 Handle	—	PROTACDB3	6.0*	—	—	Cn1c(=O)n(C2CCC(=O)NC2=O)c2ccccc21
E3 Binder	CHEMBL4637801	ChEMBL	10.0	—	—	N#Cc1ccc(N2CCN(Cc3ccc(COc4cccc5c4CN(C4CCC(=O)NC4=O)C5=O)cc3)CC2)c(F)c1
E3 Binder	CHEMBL4648616	ChEMBL	7.52	QFC	—	N#Cc1ccc(N2CCN(Cc3ccc(COc4cccc5c4CN([C@H]4CCC(=O)NC4=O)C5=O)cc3)CC2)c(F)c1
E3 Binder	CHEMBL4642706	ChEMBL	9.0	—	—	N#Cc1cccnc1N1CCN(Cc2ccc(COc3cccc4c3CN(C3CCC(=O)NC3=O)C4=O)cc2)CC1
E3 Binder	CHEMBL4639846	ChEMBL	9.4	—	—	NC(=O)c1ccc(N2CCN(Cc3ccc(COc4cccc5c4CN(C4CCC(=O)NC4=O)C5=O)cc3)CC2)cn1
E3 Handle	—	PROTACDB3	6.0*	—	—	NCC(=O)N[C@H]1CC(=O)NC1=O
E3 Handle	—	PROTACDB3	6.0*	—	—	NCC(=O)N[C@H]1CCC(=O)NC1=O
E3 Handle	—	PROTACDB3	6.0*	—	—	Nc1cc(OS(=O)(=O)F)cc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O
E3 Binder	CHEMBL4648134	ChEMBL	6.1	—	—	Nc1ccc(C(=O)NC2CCC(=O)NC2=O)c2ncccc12
E3 Binder	CHEMBL297116	ChEMBL	6.18	—	—	Nc1ccc2c(c1)C(=O)N(C1CCC(=O)NC1=O)C2
E3 Handle	CHEMBL43855	PROTACDB3, ChEMBL	6.25	—	—	Nc1ccc2c(c1)C(=O)N(C1CCC(=O)NC1=O)C2=O
E3 Binder	CHEMBL40206	ChEMBL	6.42	—	—	Nc1ccc2c(c1)CN(C1CCC(=O)NC1=O)C2=O
E3 Handle	CHEMBL43452	PROTACDB3, ChEMBL	8.05	—	—	Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O
E3 Handle	CHEMBL848	PROTACDB3, ChEMBL	7.17	—	—	Nc1cccc2c1CN(C1CCC(=O)NC1=O)C2=O
E3 Handle	—	PROTACDB3	6.0*	LVY	—	Nc1cccc2c1CN([C@H]1CCC(=O)NC1=O)C2=O
E3 Handle	—	PROTACDB3	6.0*	—	—	Nc1cccc2nnn(C3CCC(=O)NC3=O)c(=O)c12
E3 Binder	CHEMBL5288045	ChEMBL	8.0	—	—	Nc1ncnc2c1c(-c1ccc(Oc3ccccc3)cc1)nn2C1CCCN(C(=O)/C=C/CCCCCOCCOCCOCCOCCOc2cccc3c2C(=O)N(C2CCC(=O)NC2=O)C3=O)C1
E3 Binder	CHEMBL5289597	ChEMBL	8.66	—	—	Nc1ncnc2c1c(-c1ccc(Oc3ccccc3)cc1)nn2C1CCCN(C(=O)CCCCCCCOCCOCCOCCOCCOc2cccc3c2C(=O)N(C2CCC(=O)NC2=O)C3=O)C1
E3 Binder	CHEMBL5277476	ChEMBL	7.54	—	—	Nc1ncnc2c1c(-c1ccc(Oc3ccccc3)cc1)nn2C1CCCN(C(=O)c2cn(CCOCCOCCOCCCc3cccc4c3CN(C3CCC(=O)NC3=O)C4=O)nn2)C1
E3 Binder	CHEMBL5269261	ChEMBL	7.52	—	—	Nc1ncnc2c1c(-c1ccc(Oc3ccccc3)cc1)nn2C1CCCN(C(=O)c2cn(CCOCCOCCOCCNc3cccc4c3C(=O)N(C3CCC(=O)NC3=O)C4=O)nn2)C1
E3 Binder	CHEMBL5285777	ChEMBL	6.96	—	—	O=C(CCCO/N=C1C(=C2/C(=O)N(Cc3cn(CCOCCNc4cccc5c4C(=O)C(N4CCC(=O)NC4=O)C5=O)nn3)c3ccccc32)/Nc2ccccc2/1)NO
E3 Binder	CHEMBL4208229	ChEMBL	8.24	—	—	O=C(Nc1ccc(OC(F)(F)Cl)cc1)c1cnc(N2CC[C@@H](O)C2)c(-c2cc[nH]n2)c1
E3 Handle	—	PROTACDB3	6.0*	—	—	O=C1CCC(N2C(=O)c3cc4c(cc3C2=O)CNC4)C(=O)N1
E3 Handle	—	PROTACDB3	6.0*	—	—	O=C1CCC(N2C(=O)c3ccc(F)cc3C2=O)C(=O)N1
E3 Binder	CHEMBL5078004	ChEMBL	8.05	—	—	O=C1CCC(N2C(=O)c3ccc(NS(=O)(=O)c4ccc(OC(F)(F)F)cc4)cc3C2=O)C(=O)N1
E3 Binder	CHEMBL5074427	ChEMBL	7.64	—	—	O=C1CCC(N2C(=O)c3ccc(NS(=O)(=O)c4cccc(Cl)c4)cc3C2=O)C(=O)N1
E3 Binder	CHEMBL5079426	ChEMBL	8.0	—	—	O=C1CCC(N2C(=O)c3ccc(NS(=O)(=O)c4cccc(OC(F)(F)F)c4)cc3C2=O)C(=O)N1
E3 Binder	CHEMBL5078971	ChEMBL	8.52	—	—	O=C1CCC(N2C(=O)c3ccc(NS(=O)(=O)c4ccccc4)cc3C2=O)C(=O)N1
E3 Binder	CHEMBL5069911	ChEMBL	7.28	—	—	O=C1CCC(N2C(=O)c3ccc(NS(=O)(=O)c4ccccc4C(F)(F)F)cc3C2=O)C(=O)N1
E3 Binder	CHEMBL5094191	ChEMBL	10.0	—	—	O=C1CCC(N2C(=O)c3ccc(NS(=O)(=O)c4ccccc4OC(F)(F)F)cc3C2=O)C(=O)N1
E3 Binder	CHEMBL182442	ChEMBL	6.42	—	—	O=C1CCC(N2C(=O)c3ccc(O)cc3C2=O)C(=O)N1
E3 Binder	CHEMBL2324714	ChEMBL	6.2	—	—	O=C1CCC(N2C(=O)c3cccc(O)c3C2=O)C(=O)N1
E3 Binder	CHEMBL4642316	ChEMBL	8.48	—	—	O=C1CCC(N2C(=O)c3cccc(OCc4ccc(CN5CCN(c6ccc(Cl)cc6Cl)CC5)cc4)c3C2=O)C(=O)N1
E3 Binder	CHEMBL4644747	ChEMBL	8.68	—	—	O=C1CCC(N2C(=O)c3cccc(OCc4ccc(CN5CCN(c6ccc(F)cc6)CC5)cc4)c3C2=O)C(=O)N1
E3 Binder	CHEMBL4645564	ChEMBL	8.62	—	—	O=C1CCC(N2C(=O)c3cccc(OCc4ccc(CN5CCN(c6ccc(F)cc6F)CC5)cc4)c3C2=O)C(=O)N1
E3 Handle	—	PROTACDB3	6.0*	—	—	O=C1CCC(N2C(=O)c3cccc4cccc(c34)C2=O)C(=O)N1
E3 Handle	CHEMBL468	PROTACDB3, ChEMBL	7.44	—	—	O=C1CCC(N2C(=O)c3ccccc3C2=O)C(=O)N1
E3 Binder	CHEMBL4449512	ChEMBL	8.7	—	—	O=C1CCC(N2Cc3c(CCCCCNC(=O)[C@@H]4NC5(CCCCC5)[C@@]5(C(=O)Nc6cc(Cl)ccc65)[C@H]4c4cccc(Cl)c4F)cccc3C2=O)C(=O)N1
E3 Binder	CHEMBL4635421	ChEMBL	6.36	—	—	O=C1CCC(N2Cc3c(NC(=O)CNc4ccnc(N5CCC[C@@H]5CO)n4)cccc3C2=O)C(=O)N1
E3 Binder	CHEMBL4648907	ChEMBL	6.89	—	—	O=C1CCC(N2Cc3c(NC(=O)CNc4ccnc(N5CCN(c6cccc(C(F)(F)F)c6)CC5)n4)cccc3C2=O)C(=O)N1
E3 Binder	CHEMBL4645905	ChEMBL	8.82	—	—	O=C1CCC(N2Cc3c(NCc4ccc(CN5CCN(c6ccc(F)cc6F)CC5)cc4)cccc3C2=O)C(=O)N1
E3 Binder	CHEMBL2324726	ChEMBL	6.63	—	—	O=C1CCC(N2Cc3c(O)cccc3C2=O)C(=O)N1
E3 Binder	CHEMBL4644660	ChEMBL	10.0	—	—	O=C1CCC(N2Cc3c(OCc4ccc(C(=O)N5CCN(c6ccc(Cl)cc6)CC5)cc4)cccc3C2=O)C(=O)N1
E3 Binder	CHEMBL4637622	ChEMBL	10.0	—	—	O=C1CCC(N2Cc3c(OCc4ccc(C(=O)N5CCN(c6ccc(Cl)cc6Cl)CC5)cc4)cccc3C2=O)C(=O)N1
E3 Binder	CHEMBL4648954	ChEMBL	9.52	—	—	O=C1CCC(N2Cc3c(OCc4ccc(C(=O)N5CCN(c6ccc(F)cc6)CC5)cc4)cccc3C2=O)C(=O)N1
E3 Binder	CHEMBL4636184	ChEMBL	10.0	—	—	O=C1CCC(N2Cc3c(OCc4ccc(C(=O)N5CCN(c6ccc(F)cc6F)CC5)cc4)cccc3C2=O)C(=O)N1
E3 Binder	CHEMBL4641342	ChEMBL	9.22	—	—	O=C1CCC(N2Cc3c(OCc4ccc(CN5CCC(C(F)(F)F)CC5)cc4)cccc3C2=O)C(=O)N1
E3 Binder	CHEMBL4647343	ChEMBL	9.3	—	—	O=C1CCC(N2Cc3c(OCc4ccc(CN5CCC(F)(F)CC5)cc4)cccc3C2=O)C(=O)N1
E3 Binder	CHEMBL4645692	ChEMBL	9.52	—	—	O=C1CCC(N2Cc3c(OCc4ccc(CN5CCN(c6c(F)cccc6F)CC5)cc4)cccc3C2=O)C(=O)N1
E3 Binder	CHEMBL4636670	ChEMBL	10.0	—	—	O=C1CCC(N2Cc3c(OCc4ccc(CN5CCN(c6ccc(Cl)cc6)CC5)cc4)cccc3C2=O)C(=O)N1
E3 Binder	CHEMBL4642904	ChEMBL	9.7	—	—	O=C1CCC(N2Cc3c(OCc4ccc(CN5CCN(c6ccc(Cl)cc6Cl)CC5)cc4)cccc3C2=O)C(=O)N1
E3 Binder	CHEMBL4645264	ChEMBL	9.22	—	—	O=C1CCC(N2Cc3c(OCc4ccc(CN5CCN(c6ccc(Cl)cc6Cl)CC5=O)cc4)cccc3C2=O)C(=O)N1
E3 Binder	CHEMBL4640365	ChEMBL	10.0	—	—	O=C1CCC(N2Cc3c(OCc4ccc(CN5CCN(c6ccc(F)cc6)CC5)cc4)cccc3C2=O)C(=O)N1
E3 Binder	CHEMBL4645677	ChEMBL	10.0	—	—	O=C1CCC(N2Cc3c(OCc4ccc(CN5CCN(c6ccc(F)cc6F)CC5)cc4)cccc3C2=O)C(=O)N1
E3 Binder	CHEMBL4634712	ChEMBL	9.15	—	—	O=C1CCC(N2Cc3c(OCc4ccc(CN5CCN(c6ccc(F)cn6)CC5)cc4)cccc3C2=O)C(=O)N1
E3 Binder	CHEMBL4638224	ChEMBL	10.0	—	—	O=C1CCC(N2Cc3c(OCc4ccc(CN5CCN(c6cccc(F)c6)CC5)cc4)cccc3C2=O)C(=O)N1
E3 Binder	CHEMBL4647905	ChEMBL	10.0	—	—	O=C1CCC(N2Cc3c(OCc4ccc(CN5CCN(c6ccccc6)CC5)cc4)cccc3C2=O)C(=O)N1
E3 Binder	CHEMBL4641034	ChEMBL	9.7	—	—	O=C1CCC(N2Cc3c(OCc4ccc(CN5CCN(c6ccccc6F)CC5)cc4)cccc3C2=O)C(=O)N1
E3 Binder	CHEMBL4642361	ChEMBL	9.4	—	—	O=C1CCC(N2Cc3c(OCc4ccc(CN5CCN(c6ccccn6)CC5)cc4)cccc3C2=O)C(=O)N1
E3 Binder	CHEMBL4638669	ChEMBL	8.12	—	—	O=C1CCC(N2Cc3c(OCc4ccccc4)cccc3C2=O)C(=O)N1
E3 Binder	CHEMBL4742712	ChEMBL	8.05	—	—	O=C1CCC(N2Cc3cc(CNC(=O)C(F)(F)c4ccc(Cl)cc4)ccc3C2=O)C(=O)N1
E3 Handle	—	PROTACDB3	6.0*	—	—	O=C1CCC(N2Cc3cc4c(cc3C2=O)CNC4)C(=O)N1
E3 Binder	CHEMBL2324704	ChEMBL	6.47	—	—	O=C1CCC(N2Cc3cccc(O)c3C2=O)C(=O)N1
E3 Binder	CHEMBL304572	ChEMBL	6.22	—	—	O=C1CCC(N2Cc3ccccc3C2=O)C(=O)N1
E3 Handle	—	PROTACDB3	6.0*	—	—	O=C1CCC(NC(=O)c2ccccc2)C(=O)N1
E3 Handle	—	PROTACDB3	6.0*	—	—	O=C1CCC(NC(=O)c2ccccc2F)C(=O)N1
E3 Handle	—	PROTACDB3	6.0*	—	—	O=C1CCC(Nc2ccccc2)C(=O)N1
E3 Handle	—	PROTACDB3	6.0*	—	—	O=C1CCC(c2ccccc2)C(=O)N1
E3 Handle	—	PROTACDB3	6.0*	—	—	O=C1CCC(n2c(=O)oc3ccccc32)C(=O)N1
E3 Handle	—	PROTACDB3	6.0*	—	—	O=C1CCN(c2ccccc2)C(=O)N1
E3 Handle	—	PROTACDB3	6.0*	—	—	O=C1CCN(c2ccccc2Cl)C(=O)N1
E3 Binder	CHEMBL4634342	ChEMBL	9.3	—	—	O=C1CC[C@@H](N2Cc3c(OCc4ccc(CN5CCN(c6ccc(F)cc6F)CC5)cc4)cccc3C2=O)C(=O)N1
E3 Binder	CHEMBL4647587	ChEMBL	10.0	—	—	O=C1CC[C@H](N2Cc3c(OCc4ccc(CN5CCN(c6ccc(F)cc6F)CC5)cc4)cccc3C2=O)C(=O)N1
E3 Binder	CHEMBL3989927	ChEMBL	9.3	8W7	—	O=C1CC[C@H](N2Cc3c(OCc4ccc(CN5CCOCC5)cc4)cccc3C2=O)C(=O)N1

CRBN

Details:

Protein Sequence ▾

Domain Architecture (From InterPro) ▾

Protein functions ▾

Small Molecule Interactions ▾