KCNA7

Details:

UniProt Entry: Q96RP8
Gene: KCNA7
Class: Other E3 Components
Family: Adaptor
Protein length: 456
Database confidence: 0.125
InterPro: InterPro Entry
Mode of Action: unknown
AlphaFold Model: Link

Protein Sequence ▾

>Q96RP8
MEPRCPPPCG CCERLVLNVA GLRFETRART LGRFPDTLLG DPARRGRFYD DARREYFFDR
HRPSFDAVLY YYQSGGRLRR PAHVPLDVFL EEVAFYGLGA AALARLREDE GCPVPPERPL
PRRAFARQLW LLFEFPESSQ AARVLAVVSV LVILVSIVVF CLETLPDFRD DRDGTGLAAA
AAAGPFPAPL NGSSQMPGNP PRLPFNDPFF VVETLCICWF SFELLVRLLV CPSKAIFFKN
VMNLIDFVAI LPYFVALGTE LARQRGVGQQ AMSLAILRVI RLVRVFRIFK LSRHSKGLQI
LGQTLRASMR ELGLLIFFLF IGVVLFSSAV YFAEVDRVDS HFTSIPESFW WAVVTMTTVG
YGDMAPVTVG GKIVGSLCAI AGVLTISLPV PVIVSNFSYF YHRETEGEEA GMFSHVDMQP
CGPLEGKANG GLVDGEVPEL PPPLWAPPGK HLVTEV

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
9	110	Homologous_superfamily	SKP1/BTB/POZ domain superfamily	IPR011333	G3DSA:3.30.710.10
13	107	Homologous_superfamily	SKP1/BTB/POZ domain superfamily	IPR011333	SSF54695
13	113	Domain	BTB/POZ domain	IPR000210	SM00225
16	103	Domain	Potassium channel tetramerisation-type BTB domain	IPR003131	PF02214
42	53	Family	Potassium channel, voltage dependent, Kv1	IPR003972	PR01496
55	65	Family	Potassium channel, voltage dependent, Kv	IPR003968	PR01491
56	66	Family	Potassium channel, voltage dependent, Kv1	IPR003972	PR01496
99	110	Family	Potassium channel, voltage dependent, Kv1	IPR003972	PR01496
115	294	Homologous_superfamily	Voltage-dependent channel domain superfamily	IPR027359	G3DSA:1.20.120.350
133	149	Family	Potassium channel, voltage dependent, Kv1	IPR003972	PR01496
143	404	Domain	Ion transport domain	IPR005821	PF00520
156	167	Family	Potassium channel, voltage dependent, Kv1	IPR003972	PR01496
287	295	Family	Potassium channel, voltage dependent, Kv	IPR003968	PR01491
311	325	Family	Potassium channel, voltage dependent, Kv	IPR003968	PR01491
382	393	Family	Potassium channel, voltage dependent, Kv	IPR003968	PR01491

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0006811	monoatomic ion transport	Biological Process	IEA	GO_REF:0000120
GO:0006813	potassium ion transport	Biological Process	IEA	GO_REF:0000120
GO:0034220	monoatomic ion transmembrane transport	Biological Process	IEA	GO_REF:0000043
GO:0051260	protein homooligomerization	Biological Process	IEA	GO_REF:0000002
GO:0055085	transmembrane transport	Biological Process	IEA	GO_REF:0000002
GO:0071805	potassium ion transmembrane transport	Biological Process	IEA	GO_REF:0000043
GO:0001508	action potential	Biological Process	IBA	GO_REF:0000033
GO:0016020	membrane	Cellular Component	IEA	GO_REF:0000120
GO:0008076	voltage-gated potassium channel complex	Cellular Component	IEA	GO_REF:0000002
GO:0034702	monoatomic ion channel complex	Cellular Component	IEA	GO_REF:0000043
GO:0005886	plasma membrane	Cellular Component	TAS	Reactome:R-HSA-1296127
GO:0005216	monoatomic ion channel activity	Molecular Function	IEA	GO_REF:0000002
GO:0005249	voltage-gated potassium channel activity	Molecular Function	IEA	GO_REF:0000002
GO:0005267	potassium channel activity	Molecular Function	IEA	GO_REF:0000043
GO:0005251	delayed rectifier potassium channel activity	Molecular Function	IBA	GO_REF:0000033
GO:0005515	protein binding	Molecular Function	IPI	PMID:36931259

Small Molecule Interactions ▾

Type	ChEMBL Compound ID	Source	pChEMBL	PDB Compound ID	PDB Codes	SMILES
E3 Binder	CHEMBL444449	ChEMBL	7.01	—	—	O=c1ccc2c(OCCCCOc3ccccc3)c3ccoc3cc2o1

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