NACC1

Details:

UniProt Entry: Q96RE7
Gene: NACC1
Class: Other E3 Components
Family: Adaptor
Protein length: 527
Database confidence: 0.25
InterPro: InterPro Entry
Mode of Action: unknown
AlphaFold Model: Link

Protein Sequence ▾

>Q96RE7
MAQTLQMEIP NFGNSILECL NEQRLQGLYC DVSVVVKGHA FKAHRAVLAA SSSYFRDLFN
NSRSAVVELP AAVQPQSFQQ ILSFCYTGRL SMNVGDQFLL MYTAGFLQIQ EIMEKGTEFF
LKVSSPSCDS QGLHAEEAPS SEPQSPVAQT SGWPACSTPL PLVSRVKTEQ QESDSVQCMP
VAKRLWDSGQ KEAGGGGNGS RKMAKFSTPD LAANRPHQPP PPQQAPVVAA AQPAVAAGAG
QPAGGVAAAG GVVSGPSTSE RTSPGTSSAY TSDSPGSYHN EEDEEEDGGE EGMDEQYRQI
CNMYTMYSMM NVGQTAEKVE ALPEQVAPES RNRIRVRQDL ASLPAELINQ IGNRCHPKLY
DEGDPSEKLE LVTGTNVYIT RAQLMNCHVS AGTRHKVLLR RLLASFFDRN TLANSCGTGI
RSSTNDPRRK PLDSRVLHAV KYYCQNFAPN FKESEMNAIA ADMCTNARRV VRKSWMPKVK
VLKAEDDAYT TFISETGKIE PDMMGVEHGF ETASHEGEAG PSAEALQ

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
1	125	Homologous_superfamily	SKP1/BTB/POZ domain superfamily	IPR011333	G3DSA:3.30.710.10
3	120	Homologous_superfamily	SKP1/BTB/POZ domain superfamily	IPR011333	SSF54695
20	120	Domain	BTB/POZ domain	IPR000210	PF00651
30	124	Domain	BTB/POZ domain	IPR000210	SM00225
30	94	Domain	BTB/POZ domain	IPR000210	PS50097
374	471	Domain	BEN domain	IPR018379	PS51457
396	471	Domain	BEN domain	IPR018379	SM01025
398	455	Domain	BEN domain	IPR018379	PF10523

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0000122	negative regulation of transcription by RNA polymerase II	Biological Process	IEA	GO_REF:0000108
GO:0006357	regulation of transcription by RNA polymerase II	Biological Process	IBA	GO_REF:0000033
GO:0008284	positive regulation of cell population proliferation	Biological Process	IMP	PMID:17804717
GO:0042127	regulation of cell population proliferation	Biological Process	IEA	GO_REF:0000117
GO:0045892	negative regulation of DNA-templated transcription	Biological Process	IEA	GO_REF:0000117
GO:0005654	nucleoplasm	Cellular Component	IDA	GO_REF:0000052
GO:0030054	cell junction	Cellular Component	IDA	GO_REF:0000052
GO:0005634	nucleus	Cellular Component	IEA	GO_REF:0000044
GO:0005737	cytoplasm	Cellular Component	IEA	GO_REF:0000120
GO:0031981	nuclear lumen	Cellular Component	IEA	GO_REF:0000117
GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Molecular Function	ISS	GO_REF:0000024
GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	Molecular Function	IBA	GO_REF:0000033
GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	Molecular Function	ISS	GO_REF:0000024
GO:0003677	DNA binding	Molecular Function	IEA	GO_REF:0000002
GO:0005515	protein binding	Molecular Function	IPI	PMID:28514442
GO:0042826	histone deacetylase binding	Molecular Function	ISS	GO_REF:0000024

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