ASB2

Details:

UniProt Entry: Q96Q27
Gene: ASB2
Class: Other E3 Components
Family: Receptor
Protein length: 635
Database confidence: 0.75
InterPro: InterPro Entry
Mode of Action: unknown
AlphaFold Model: Link

Protein Sequence ▾

>Q96Q27
MATQISTRGS QCTIGQEEYS LYSSLSEDEL VQMAIEQSLA DKTRGPTTAE ATASACTNRQ
PAHFYPWTRS TAPPESSPAR APMGLFQGVM QKYSSSLFKT SQLAPADPLI KAIKDGDEEA
LKTMIKEGKN LAEPNKEGWL PLHEAAYYGQ VGCLKVLQRA YPGTIDQRTL QEETAVYLAT
CRGHLDCLLS LLQAGAEPDI SNKSRETPLY KACERKNAEA VKILVQHNAD TNHRCNRGWT
ALHESVSRND LEVMQILVSG GAKVESKNAY GITPLFVAAQ SGQLEALRFL AKYGADINTQ
ASDNASALYE ACKNEHEEVV EFLLSQGADA NKTNKDGLLP LHIASKKGNY RIVQMLLPVT
SRTRIRRSGV SPLHLAAERN HDEVLEALLS ARFDVNTPLA PERARLYEDR RSSALYFAVV
NNNVYATELL LQHGADPNRD VISPLLVAIR HGCLRTMQLL LDHGANIDAY IATHPTAFPA
TIMFAMKCLS LLKFLMDLGC DGEPCFSCLY GNGPHPPAPQ PSSRFNDAPA ADKEPSVVQF
CEFVSAPEVS RWAGPIIDVL LDYVGNVQLC SRLKEHIDSF EDWAVIKEKA EPPRPLAHLC
RLRVRKAIGK YRIKLLDTLP LPGRLIRYLK YENTQ

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
104	133	Repeat	Ankyrin repeat	IPR002110	SM00248
104	205	Homologous_superfamily	Ankyrin repeat-containing domain superfamily	IPR036770	G3DSA:1.25.40.20
108	157	Repeat	Ankyrin repeat	IPR002110	PF13637
108	478	Homologous_superfamily	Ankyrin repeat-containing domain superfamily	IPR036770	SSF48403
137	167	Repeat	Ankyrin repeat	IPR002110	SM00248
171	203	Repeat	Ankyrin repeat	IPR002110	PS50088
171	200	Repeat	Ankyrin repeat	IPR002110	SM00248
178	268	Repeat	Ankyrin repeat	IPR002110	PF12796
204	233	Repeat	Ankyrin repeat	IPR002110	SM00248
204	236	Repeat	Ankyrin repeat	IPR002110	PS50088
206	364	Homologous_superfamily	Ankyrin repeat-containing domain superfamily	IPR036770	G3DSA:1.25.40.20
237	269	Repeat	Ankyrin repeat	IPR002110	PS50088
237	266	Repeat	Ankyrin repeat	IPR002110	SM00248
270	302	Repeat	Ankyrin repeat	IPR002110	PS50088
270	298	Repeat	Ankyrin repeat	IPR002110	PF13606
270	299	Repeat	Ankyrin repeat	IPR002110	SM00248
271	286	Repeat	Ankyrin repeat	IPR002110	PR01415
303	335	Repeat	Ankyrin repeat	IPR002110	PS50088
303	332	Repeat	Ankyrin repeat	IPR002110	SM00248
308	397	Repeat	Ankyrin repeat	IPR002110	PF12796
319	333	Repeat	Ankyrin repeat	IPR002110	PR01415
336	368	Repeat	Ankyrin repeat	IPR002110	PS50088
336	365	Repeat	Ankyrin repeat	IPR002110	SM00248
365	513	Homologous_superfamily	Ankyrin repeat-containing domain superfamily	IPR036770	G3DSA:1.25.40.20
368	400	Repeat	Ankyrin repeat	IPR002110	PS50088
368	397	Repeat	Ankyrin repeat	IPR002110	SM00248
410	439	Repeat	Ankyrin repeat	IPR002110	SM00248
410	438	Repeat	Ankyrin repeat	IPR002110	PS50088
440	472	Repeat	Ankyrin repeat	IPR002110	PS50088
440	469	Repeat	Ankyrin repeat	IPR002110	SM00248
585	633	Homologous_superfamily	SOCS box-like domain superfamily	IPR036036	SSF158235
586	635	Domain	SOCS box domain	IPR001496	PS50225
587	633	Domain	SOCS box domain	IPR001496	SM00253
591	635	Domain	Ankyrin repeat and SOCS box protein 2, SOCS box domain	IPR037330	cd03721
593	632	Domain	SOCS box domain	IPR001496	SM00969
593	630	Domain	SOCS box domain	IPR001496	PF07525

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0035914	skeletal muscle cell differentiation	Biological Process	IEA	GO_REF:0000107
GO:0001947	heart looping	Biological Process	IEA	GO_REF:0000107
GO:0007165	signal transduction	Biological Process	TAS	PMID:9419338
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000120
GO:0030036	actin cytoskeleton organization	Biological Process	ISS	GO_REF:0000024
GO:0035556	intracellular signal transduction	Biological Process	IEA	GO_REF:0000002
GO:0036336	dendritic cell migration	Biological Process	ISS	GO_REF:0000024
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	Biological Process	ISS	GO_REF:0000024
GO:0055007	cardiac muscle cell differentiation	Biological Process	IEA	GO_REF:0000117
GO:0055013	cardiac muscle cell development	Biological Process	ISS	GO_REF:0000024
GO:0071800	podosome assembly	Biological Process	ISS	GO_REF:0000024
GO:2000812	regulation of barbed-end actin filament capping	Biological Process	IBA	GO_REF:0000033
GO:0005737	cytoplasm	Cellular Component	IEA	GO_REF:0000120
GO:0000151	ubiquitin ligase complex	Cellular Component	IEA	GO_REF:0000117
GO:0005634	nucleus	Cellular Component	IBA	GO_REF:0000033
GO:0001725	stress fiber	Cellular Component	IEA	GO_REF:0000044
GO:0005829	cytosol	Cellular Component	IEA	GO_REF:0000117
GO:0005856	cytoskeleton	Cellular Component	IEA	GO_REF:0000043
GO:0030018	Z disc	Cellular Component	IEA	GO_REF:0000044
GO:0061630	ubiquitin protein ligase activity	Molecular Function	IDA	PMID:16325183
GO:0005515	protein binding	Molecular Function	IPI	PMID:21119685
GO:0097602	cullin family protein binding	Molecular Function	IPI	PMID:21119685

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