NED4L

>Q96PU5
MATGLGEPVY GLSEDEGESR ILRVKVVSGI DLAKKDIFGA SDPYVKLSLY VADENRELAL
VQTKTIKKTL NPKWNEEFYF RVNPSNHRLL FEVFDENRLT RDDFLGQVDV PLSHLPTEDP
TMERPYTFKD FLLRPRSHKS RVKGFLRLKM AYMPKNGGQD EENSDQRDDM EHGWEVVDSN
DSASQHQEEL PPPPLPPGWE EKVDNLGRTY YVNHNNRTTQ WHRPSLMDVS SESDNNIRQI
NQEAAHRRFR SRRHISEDLE PEPSEGGDVP EPWETISEEV NIAGDSLGLA LPPPPASPGS
RTSPQELSEE LSRRLQITPD SNGEQFSSLI QREPSSRLRS CSVTDAVAEQ GHLPPPSAPA
GRARSSTVTG GEEPTPSVAY VHTTPGLPSG WEERKDAKGR TYYVNHNNRT TTWTRPIMQL
AEDGASGSAT NSNNHLIEPQ IRRPRSLSSP TVTLSAPLEG AKDSPVRRAV KDTLSNPQSP
QPSPYNSPKP QHKVTQSFLP PGWEMRIAPN GRPFFIDHNT KTTTWEDPRL KFPVHMRSKT
SLNPNDLGPL PPGWEERIHL DGRTFYIDHN SKITQWEDPR LQNPAITGPA VPYSREFKQK
YDYFRKKLKK PADIPNRFEM KLHRNNIFEE SYRRIMSVKR PDVLKARLWI EFESEKGLDY
GGVAREWFFL LSKEMFNPYY GLFEYSATDN YTLQINPNSG LCNEDHLSYF TFIGRVAGLA
VFHGKLLDGF FIRPFYKMML GKQITLNDME SVDSEYYNSL KWILENDPTE LDLMFCIDEE
NFGQTYQVDL KPNGSEIMVT NENKREYIDL VIQWRFVNRV QKQMNAFLEG FTELLPIDLI
KIFDENELEL LMCGLGDVDV NDWRQHSIYK NGYCPNHPVI QWFWKAVLLM DAEKRIRLLQ
FVTGTSRVPM NGFAELYGSN GPQLFTIEQW GSPEKLPRAH TCFNRLDLPP YETFEDLREK
LLMAVENAQG FEGVD

The same domains may appear in multiple rows, following InterPro convention.

Start	End	Type	Name	InterPro	Source
4	126	Domain	C2 domain	IPR000008	PS50004
11	116	Family	E3 ubiquitin-protein ligase, SMURF1 type	IPR024928	PIRSF001569
15	188	Homologous_superfamily	C2 domain superfamily	IPR035892	G3DSA:2.60.40.150
21	119	Domain	C2 domain	IPR000008	PF00168
21	159	Homologous_superfamily	C2 domain superfamily	IPR035892	SSF49562
21	124	Domain	C2 domain	IPR000008	SM00239
37	49	Domain	C2 domain	IPR000008	PR00360
68	81	Domain	C2 domain	IPR000008	PR00360
148	269	Family	E3 ubiquitin-protein ligase, SMURF1 type	IPR024928	PIRSF001569
185	227	Homologous_superfamily	WW domain superfamily	IPR036020	SSF51045
193	226	Domain	WW domain	IPR001202	PS50020
194	226	Domain	WW domain	IPR001202	SM00456
195	224	Domain	WW domain	IPR001202	PF00397
198	224	Domain	WW domain	IPR001202	cd00201
199	224	Domain	WW domain	IPR001202	PS01159
296	973	Family	E3 ubiquitin-protein ligase, SMURF1 type	IPR024928	PIRSF001569
380	419	Homologous_superfamily	WW domain superfamily	IPR036020	SSF51045
385	418	Domain	WW domain	IPR001202	PS50020
386	418	Domain	WW domain	IPR001202	SM00456
387	416	Domain	WW domain	IPR001202	PF00397
388	416	Domain	WW domain	IPR001202	cd00201
391	416	Domain	WW domain	IPR001202	PS01159
497	530	Domain	WW domain	IPR001202	PS50020
498	532	Homologous_superfamily	WW domain superfamily	IPR036020	SSF51045
498	530	Domain	WW domain	IPR001202	SM00456
499	528	Domain	WW domain	IPR001202	PF00397
500	530	Domain	WW domain	IPR001202	cd00201
503	528	Domain	WW domain	IPR001202	PS01159
544	583	Homologous_superfamily	WW domain superfamily	IPR036020	SSF51045
548	581	Domain	WW domain	IPR001202	PS50020
549	581	Domain	WW domain	IPR001202	SM00456
550	579	Domain	WW domain	IPR001202	PF00397
551	581	Domain	WW domain	IPR001202	cd00201
554	579	Domain	WW domain	IPR001202	PS01159
601	968	Homologous_superfamily	HECT, E3 ligase catalytic domain	IPR035983	SSF56204
618	972	Domain	HECT domain	IPR000569	cd00078
638	974	Domain	HECT domain	IPR000569	SM00119
640	974	Domain	HECT domain	IPR000569	PS50237
670	972	Domain	HECT domain	IPR000569	PF00632

GO term	Name	Ontology	Evidence	Reference
GO:0006511	ubiquitin-dependent protein catabolic process	Biological Process	IEA	GO_REF:0000117
GO:0006811	monoatomic ion transport	Biological Process	IEA	GO_REF:0000117
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000120
GO:0030154	cell differentiation	Biological Process	IEA	GO_REF:0000043
GO:0065008	regulation of biological quality	Biological Process	IEA	GO_REF:0000117
GO:0051049	regulation of transport	Biological Process	IEA	GO_REF:0000117
GO:0098719	sodium ion import across plasma membrane	Biological Process	IDA	PMID:17502380
GO:0003254	regulation of membrane depolarization	Biological Process	IDA	PMID:15217910
GO:0006513	protein monoubiquitination	Biological Process	IEA	GO_REF:0000107
GO:0007528	neuromuscular junction development	Biological Process	IBA	GO_REF:0000033
GO:0031175	neuron projection development	Biological Process	IBA	GO_REF:0000033
GO:0031623	receptor internalization	Biological Process	IBA	GO_REF:0000033
GO:0031647	regulation of protein stability	Biological Process	IMP	PMID:27445338
GO:0032801	receptor catabolic process	Biological Process	IBA	GO_REF:0000033
GO:0034220	monoatomic ion transmembrane transport	Biological Process	TAS	Reactome:R-HSA-983712
GO:0042391	regulation of membrane potential	Biological Process	IDA	PMID:17289006
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	Biological Process	IDA	PMID:21463633
GO:0045732	positive regulation of protein catabolic process	Biological Process	IEA	GO_REF:0000107
GO:0048814	regulation of dendrite morphogenesis	Biological Process	IBA	GO_REF:0000033
GO:0050807	regulation of synapse organization	Biological Process	IBA	GO_REF:0000033
GO:0060306	regulation of membrane repolarization	Biological Process	IDA	PMID:21463633
GO:0070936	protein K48-linked ubiquitination	Biological Process	IDA	PMID:21463633
GO:0086005	ventricular cardiac muscle cell action potential	Biological Process	ISS	PMID:22879586
GO:1901380	negative regulation of potassium ion transmembrane transport	Biological Process	IDA	PMID:21463633
GO:1902305	regulation of sodium ion transmembrane transport	Biological Process	IDA	PMID:11244092
GO:1902306	negative regulation of sodium ion transmembrane transport	Biological Process	IDA	PMID:15217910
GO:1903765	negative regulation of potassium ion export across plasma membrane	Biological Process	IDA	PMID:17289006
GO:1903783	negative regulation of sodium ion import across plasma membrane	Biological Process	IDA	PMID:18174164
GO:1903861	positive regulation of dendrite extension	Biological Process	IDA	PMID:23999003
GO:2000009	negative regulation of protein localization to cell surface	Biological Process	IDA	PMID:21463633
GO:2001288	positive regulation of caveolin-mediated endocytosis	Biological Process	ISS	PMID:22879586
GO:0005737	cytoplasm	Cellular Component	IEA	GO_REF:0000044
GO:0005768	endosome	Cellular Component	IEA	GO_REF:0000043
GO:0005771	multivesicular body	Cellular Component	IEA	GO_REF:0000044
GO:0005794	Golgi apparatus	Cellular Component	IEA	GO_REF:0000120
GO:0005634	nucleus	Cellular Component	IEA	GO_REF:0000120
GO:0005923	bicellular tight junction	Cellular Component	IEA	GO_REF:0000120
GO:0005886	plasma membrane	Cellular Component	IDA	PMID:22879586
GO:0016324	apical plasma membrane	Cellular Component	IDA	PMID:18174164
GO:0005654	nucleoplasm	Cellular Component	TAS	Reactome:R-HSA-2176491
GO:0005829	cytosol	Cellular Component	TAS	Reactome:R-HSA-2682349
GO:0070062	extracellular exosome	Cellular Component	HDA	PMID:23533145
GO:0004842	ubiquitin-protein transferase activity	Molecular Function	IEA	GO_REF:0000002
GO:0016740	transferase activity	Molecular Function	IEA	GO_REF:0000043
GO:0019871	sodium channel inhibitor activity	Molecular Function	IEA	GO_REF:0000117
GO:0061630	ubiquitin protein ligase activity	Molecular Function	IEA	GO_REF:0000120
GO:0005515	protein binding	Molecular Function	IPI	PMID:11244092
GO:0017080	sodium channel regulator activity	Molecular Function	IDA	PMID:11244092
GO:0019870	potassium channel inhibitor activity	Molecular Function	IDA	PMID:17289006
GO:0044325	transmembrane transporter binding	Molecular Function	IPI	PMID:15217910

Substrate	Name	Known ESI (UbiBrowser)	Known ESI (UbiNet)	PPI (IntAct direct) PSI-MI score ≥ 0.5	PPI (IntAct indirect) PSI-MI scores ≥ 0.5 for both PPIs	PubMed Ref.	IntAct Ref.	Substrate Specificity
Q6UUV7	CRTC3	Yes	Yes	No	No	—	No	E3-specific
Q8WXF1	PSPC1	Yes	Yes	No	No	—	No	E3-specific
O15527	OGG1	Yes	No	No	No	—	No	E3-specific
P43003	EAA1	Yes	Yes	No	No	—	No	E3-specific
P11686	PSPC	Yes	No	No	No	—	No	E3-specific
Q9UQD0	SCN8A	Yes	Yes	No	No	—	No	E3-specific
Q9Y5Y9	SCNAA	Yes	Yes	No	No	—	No	E3-specific
P22001	KCNA3	Yes	Yes	No	No	—	No	E3-specific
Q15858	SCN9A	Yes	Yes	No	No	—	No	E3-specific
Q9NY46	SCN3A	Yes	Yes	No	No	—	No	E3-specific
Q9NV92	NFIP2	Yes	Yes	No	No	—	No	Cluster-specific
Q96QD8	S38A2	Yes	Yes	No	No	—	No	E3-specific
Q9H1D0	TRPV6	Yes	Yes	No	No	—	No	E3-specific
P51795	CLCN5	Yes	Yes	No	No	—	No	E3-specific
P33527	MRP1	Yes	No	No	No	—	No	E3-specific
Q4VCS5	AMOT	Yes	Yes	Yes	No	19615732, 24981860	EBI-25481854	Cluster-specific
Q9BXB1	LGR4	Yes	Yes	No	No	—	No	Cluster-specific
P51168	SCNNB	Yes	Yes	No	No	21765395	EBI-7027942	Cluster-specific
O75473	LGR5	Yes	Yes	No	No	—	No	Cluster-specific
Q16620	NTRK2	Yes	Yes	No	No	—	No	E3-specific
Q12809	KCNH2	Yes	Yes	No	No	—	No	E3-specific
Q96PU5	NED4L	Yes	Yes	No	No	—	No	E3-specific
Q16625	OCLN	Yes	Yes	No	No	28514442	EBI-21730413	Cluster-specific
Q9NRA0	SPHK2	Yes	No	No	No	—	No	E3-specific
P51170	SCNNG	Yes	Yes	No	No	—	No	Cluster-specific
Q01959	SC6A3	Yes	Yes	No	No	—	No	Cluster-specific
Q9P2K8	E2AK4	Yes	Yes	No	No	—	No	E3-specific
Q01813	PFKAP	Yes	No	No	No	—	No	E3-specific
Q96D31	CRCM1	Yes	Yes	No	No	—	No	E3-specific
P49281	NRAM2	Yes	Yes	No	No	19706893	EBI-15801652	Cluster-specific
Q6PJG6	BRAT1	Yes	Yes	No	No	—	No	Cluster-specific
P37088	SCNNA	Yes	Yes	No	No	—	No	E3-specific
Q14524	SCN5A	Yes	Yes	No	No	—	No	Cluster-specific
Q8TDR2	STK35	Yes	No	No	No	—	No	E3-specific
O76090	BEST1	Yes	No	No	No	—	No	E3-specific
P62745	RHOB	Yes	Yes	No	No	—	No	E3-specific
Q99250	SCN2A	Yes	Yes	No	No	—	No	E3-specific
Q9BSA4	TTYH2	Yes	Yes	No	No	—	No	Cluster-specific
O00213	APBB1	Yes	Yes	No	No	—	No	E3-specific
Q8TCC7	S22A8	Yes	No	No	No	—	No	E3-specific
P53805	RCAN1	Yes	Yes	No	No	—	No	E3-specific