UHRF2

Details:

UniProt Entry: Q96PU4
Gene: UHRF2
Class: RING
Family: RING7
Protein length: 802
Database confidence: 1.0
InterPro: InterPro Entry
Mode of Action: Standalone
AlphaFold Model: Link
PDB Structures: 1wy8, 1z6u, 2e6s, 3oln, 4pw5, 4pw6, 4pw7, 4tvr, 5yco

Protein Sequence ▾

>Q96PU4
MWIQVRTIDG SKTCTIEDVS RKATIEELRE RVWALFDVRP ECQRLFYRGK QLENGYTLFD
YDVGLNDIIQ LLVRPDPDHL PGTSTQIEAK PCSNSPPKVK KAPRVGPSNQ PSTSARARLI
DPGFGIYKVN ELVDARDVGL GAWFEAHIHS VTRASDGQSR GKTPLKNGSS CKRTNGNIKH
KSKENTNKLD SVPSTSNSDC VAADEDVIYH IQYDEYPESG TLEMNVKDLR PRARTILKWN
ELNVGDVVMV NYNVESPGQR GFWFDAEITT LKTISRTKKE LRVKIFLGGS EGTLNDCKII
SVDEIFKIER PGAHPLSFAD GKFLRRNDPE CDLCGGDPEK KCHSCSCRVC GGKHEPNMQL
LCDECNVAYH IYCLNPPLDK VPEEEYWYCP SCKTDSSEVV KAGERLKMSK KKAKMPSAST
ESRRDWGRGM ACVGRTRECT IVPSNHYGPI PGIPVGSTWR FRVQVSEAGV HRPHVGGIHG
RSNDGAYSLV LAGGFADEVD RGDEFTYTGS GGKNLAGNKR IGAPSADQTL TNMNRALALN
CDAPLDDKIG AESRNWRAGK PVRVIRSFKG RKISKYAPEE GNRYDGIYKV VKYWPEISSS
HGFLVWRYLL RRDDVEPAPW TSEGIERSRR LCLRLQYPAG YPSDKEGKKP KGQSKKQPSG
TTKRPISDDD CPSASKVYKA SDSAEAIEAF QLTPQQQHLI REDCQNQKLW DEVLSHLVEG
PNFLKKLEQS FMCVCCQELV YQPVTTECFH NVCKDCLQRS FKAQVFSCPA CRHDLGQNYI
MIPNEILQTL LDLFFPGYSK GR

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
1	84	Homologous_superfamily	Ubiquitin-like domain superfamily	IPR029071	SSF54236
1	74	Domain	Ubiquitin-like domain	IPR000626	PS50053
1	74	Domain	Ubiquitin-like domain	IPR000626	SM00213
3	75	Domain	Ubiquitin-like domain	IPR000626	PF00240
33	799	Family	UHRF1/2-like	IPR045134	PTHR14140
125	312	Domain	UHRF1, tandem tudor domain	IPR021991	PF12148
343	397	Homologous_superfamily	Zinc finger, FYVE/PHD-type	IPR011011	SSF57903
344	395	Domain	Zinc finger, PHD-finger	IPR019787	PS50016
346	393	Domain	Zinc finger, PHD-type	IPR001965	SM00249
347	392	Domain	Zinc finger, RING-type	IPR001841	SM00184
347	394	Domain	Zinc finger, PHD-finger	IPR019787	PF00628
428	639	Homologous_superfamily	SRA-YDG superfamily	IPR036987	G3DSA:2.30.280.10
429	633	Homologous_superfamily	PUA-like superfamily	IPR015947	SSF88697
443	616	Domain	SRA-YDG	IPR003105	SM00466
446	614	Domain	SRA-YDG	IPR003105	PF02182
448	612	Domain	SRA-YDG	IPR003105	PS51015
688	802	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
733	771	Domain	Zinc finger, RING-type	IPR001841	SM00184
733	772	Domain	Zinc finger, RING-type	IPR001841	PS50089
748	757	Conserved_site	Zinc finger, RING-type, conserved site	IPR017907	PS00518

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000104
GO:0006357	regulation of transcription by RNA polymerase II	Biological Process	NAS	PMID:27129234
GO:0016925	protein sumoylation	Biological Process	TAS	Reactome:R-HSA-3108232
GO:0030154	cell differentiation	Biological Process	IEP	PMID:12176013
GO:0044027	negative regulation of gene expression via chromosomal CpG island methylation	Biological Process	IBA	GO_REF:0000033
GO:0051726	regulation of cell cycle	Biological Process	TAS	PMID:14741369
GO:0051865	protein autoubiquitination	Biological Process	IEA	GO_REF:0000117
GO:0005634	nucleus	Cellular Component	IEA	GO_REF:0000120
GO:0000792	heterochromatin	Cellular Component	ISS	GO_REF:0000024
GO:0005654	nucleoplasm	Cellular Component	IDA	GO_REF:0000052
GO:0005694	chromosome	Cellular Component	IEA	GO_REF:0000120
GO:0005721	pericentric heterochromatin	Cellular Component	IDA	PMID:27129234
GO:0003677	DNA binding	Molecular Function	IEA	GO_REF:0000043
GO:0004842	ubiquitin-protein transferase activity	Molecular Function	IEA	GO_REF:0000104
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0016740	transferase activity	Molecular Function	IEA	GO_REF:0000043
GO:0042393	histone binding	Molecular Function	IEA	GO_REF:0000104
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0061630	ubiquitin protein ligase activity	Molecular Function	IEA	GO_REF:0000104
GO:0005515	protein binding	Molecular Function	IPI	PMID:12176013
GO:0019789	SUMO transferase activity	Molecular Function	EXP	PMID:22467880
GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	Molecular Function	IPI	PMID:27129234
GO:0062072	histone H3K9me2/3 reader activity	Molecular Function	TAS	PMID:27129234

Enzyme–Substrate Interactions ▾


Q8WW12	PCNP	Yes	Yes	No	No	—	No	E3-specific

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