KLHL5

Details:

UniProt Entry: Q96PQ7
Gene: KLHL5
Class: Other E3 Components
Family: Adaptor
Protein length: 755
Database confidence: 0.375
InterPro: InterPro Entry
Mode of Action: unknown
AlphaFold Model: Link

Protein Sequence ▾

>Q96PQ7
MNVIYFPLHI FVVYSRAYTS LVLVGCTNLC AVLFARCLDD HLVSLRMSGS RKEFDVKQIL
KIRWRWFGHQ ASSPNSTVDS QQGEFWNRGQ TGANGGRKFL DPCSLQLPLA SIGYRRSSQL
DFQNSPSWPM ASTSEVPAFE FTAEDCGGAH WLDRPEVDDG TSEEENESDS SSCRTSNSSQ
TLSSCHTMEP CTSDEFFQAL NHAEQTFKKM ENYLRHKQLC DVILVAGDRR IPAHRLVLSS
VSDYFAAMFT NDVREARQEE IKMEGVEPNS LWSLIQYAYT GRLELKEDNI ECLLSTACLL
QLSQVVEACC KFLMKQLHPS NCLGIRSFAD AQGCTDLHKV AHNYTMEHFM EVIRNQEFVL
LPASEIAKLL ASDDMNIPNE ETILNALLTW VRHDLEQRRK DLSKLLAYIR LPLLAPQFLA
DMENNVLFRD DIECQKLIME AMKYHLLPER RPMLQSPRTK PRKSTVGTLF AVGGMDSTKG
ATSIEKYDLR TNMWTPVANM NGRRLQFGVA VLDDKLYVVG GRDGLKTLNT VECYNPKTKT
WSVMPPMSTH RHGLGVAVLE GPMYAVGGHD GWSYLNTVER WDPQARQWNF VATMSTPRST
VGVAVLSGKL YAVGGRDGSS CLKSVECFDP HTNKWTLCAQ MSKRRGGVGV TTWNGLLYAI
GGHDAPASNL TSRLSDCVER YDPKTDMWTA VASMSISRDA VGVCLLGDKL YAVGGYDGQA
YLNTVEAYDP QTNEWTQVAP LCLGRAGACV VTVKL

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
192	318	Homologous_superfamily	SKP1/BTB/POZ domain superfamily	IPR011333	G3DSA:3.30.710.10
197	326	Domain	Kelch-like protein 5, BTB/POZ domain	IPR030606	cd18337
201	315	Homologous_superfamily	SKP1/BTB/POZ domain superfamily	IPR011333	SSF54695
211	316	Domain	BTB/POZ domain	IPR000210	PF00651
220	287	Domain	BTB/POZ domain	IPR000210	PS50097
220	317	Domain	BTB/POZ domain	IPR000210	SM00225
322	421	Domain	BTB/Kelch-associated	IPR011705	PF07707
322	423	Domain	BTB/Kelch-associated	IPR011705	SM00875
456	651	Homologous_superfamily	Kelch-type beta propeller	IPR015915	G3DSA:2.120.10.80
467	501	Repeat	Kelch repeat type 1	IPR006652	PF01344
468	514	Repeat	Kelch repeat type 1	IPR006652	SM00612
468	665	Homologous_superfamily	Kelch-type beta propeller	IPR015915	SSF117281
503	548	Repeat	Kelch repeat type 1	IPR006652	PF01344
515	561	Repeat	Kelch repeat type 1	IPR006652	SM00612
551	595	Repeat	Kelch repeat type 1	IPR006652	PF01344
562	608	Repeat	Kelch repeat type 1	IPR006652	SM00612
597	642	Repeat	Kelch repeat type 1	IPR006652	PF01344
609	655	Repeat	Kelch repeat type 1	IPR006652	SM00612
621	753	Homologous_superfamily	Kelch-type beta propeller	IPR015915	SSF117281
644	695	Repeat	Kelch repeat type 1	IPR006652	PF01344
652	754	Homologous_superfamily	Kelch-type beta propeller	IPR015915	G3DSA:2.120.10.80
656	708	Repeat	Kelch repeat type 1	IPR006652	SM00612
700	741	Repeat	Kelch repeat type 1	IPR006652	PF01344
709	755	Repeat	Kelch repeat type 1	IPR006652	SM00612

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	Biological Process	IBA	GO_REF:0000033
GO:0005886	plasma membrane	Cellular Component	IDA	GO_REF:0000052
GO:0015630	microtubule cytoskeleton	Cellular Component	IDA	GO_REF:0000052
GO:0005856	cytoskeleton	Cellular Component	IEA	GO_REF:0000120
GO:0005737	cytoplasm	Cellular Component	IBA	GO_REF:0000033
GO:0005829	cytosol	Cellular Component	TAS	Reactome:R-HSA-8952630
GO:0031463	Cul3-RING ubiquitin ligase complex	Cellular Component	IBA	GO_REF:0000033
GO:0003779	actin binding	Molecular Function	IEA	GO_REF:0000043
GO:0005515	protein binding	Molecular Function	IPI	PMID:21145461
GO:1990756	ubiquitin-like ligase-substrate adaptor activity	Molecular Function	IBA	GO_REF:0000033

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