BIRC8

Details:

UniProt Entry: Q96P09
Gene: BIRC8
Class: RING
Family: RING3
Protein length: 236
Database confidence: 0.375
InterPro: InterPro Entry
Mode of Action: Standalone
AlphaFold Model: Link
PDB Structures: 1xb0, 1xb1

Protein Sequence ▾

>Q96P09
MTGYEARLIT FGTWMYSVNK EQLARAGFYA IGQEDKVQCF HCGGGLANWK PKEDPWEQHA
KWYPGCKYLL EEKGHEYINN IHLTRSLEGA LVQTTKKTPS LTKRISDTIF PNPMLQEAIR
MGFDFKDVKK IMEERIQTSG SNYKTLEVLV ADLVSAQKDT TENELNQTSL QREISPEEPL
RRLQEEKLCK ICMDRHIAVV FIPCGHLVTC KQCAEAVDRC PMCSAVIDFK QRVFMS

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
2	71	Repeat	BIR repeat	IPR001370	SM00238
4	69	Repeat	BIR repeat	IPR001370	PS01282
5	70	Repeat	BIR repeat	IPR001370	cd00022
7	70	Repeat	BIR repeat	IPR001370	PS50143
7	69	Repeat	BIR repeat	IPR001370	PF00653
109	158	Domain	XIAP/BIRC8, UBA domain	IPR042579	cd14395
173	197	Homologous_superfamily	Death-like domain superfamily	IPR011029	G3DSA:1.10.533.10
189	224	Domain	Zinc finger, RING-type	IPR001841	PS50089
189	223	Domain	Zinc finger, RING-type	IPR001841	SM00184

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0006915	apoptotic process	Biological Process	IEA	GO_REF:0000043
GO:0010804	negative regulation of tumor necrosis factor-mediated signaling pathway	Biological Process	IEA	GO_REF:0000117
GO:0042981	regulation of apoptotic process	Biological Process	IEA	GO_REF:0000117
GO:0046330	positive regulation of JNK cascade	Biological Process	IEA	GO_REF:0000117
GO:0031398	positive regulation of protein ubiquitination	Biological Process	IBA	GO_REF:0000033
GO:0043066	negative regulation of apoptotic process	Biological Process	IBA	GO_REF:0000033
GO:0051726	regulation of cell cycle	Biological Process	IBA	GO_REF:0000033
GO:0090263	positive regulation of canonical Wnt signaling pathway	Biological Process	IBA	GO_REF:0000033
GO:0005737	cytoplasm	Cellular Component	IEA	GO_REF:0000120
GO:0005634	nucleus	Cellular Component	IBA	GO_REF:0000033
GO:0004842	ubiquitin-protein transferase activity	Molecular Function	IEA	GO_REF:0000117
GO:0004869	cysteine-type endopeptidase inhibitor activity	Molecular Function	IEA	GO_REF:0000117
GO:0005515	protein binding	Molecular Function	IPI	PMID:25416956
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process	Molecular Function	IBA	GO_REF:0000033
GO:0061630	ubiquitin protein ligase activity	Molecular Function	IBA	GO_REF:0000033

Enzyme–Substrate Interactions ▾

Small Molecule Interactions ▾

Type	ChEMBL Compound ID	Source	pChEMBL	PDB Compound ID	PDB Codes	SMILES
E3 Binder	CHEMBL481422	ChEMBL	8.74	—	—	CN[C@@H](C)C(=O)N[C@H]1CCCC[C@H]2CC[C@@H](C(=O)NC(c3ccccc3)c3ccccc3)N2C1=O
E3 Binder	CHEMBL504559	ChEMBL	8.38	—	—	CN[C@@H](C)C(=O)N[C@H]1CN(C(=O)Cc2ccccc2)CC[C@H]2CC[C@@H](C(=O)NC(c3ccccc3)c3ccccc3)N2C1=O
E3 Binder	CHEMBL456400	ChEMBL	8.72	—	—	CN[C@@H](C)C(=O)N[C@H]1CN(C(C)=O)CC[C@H]2CC[C@@H](C(=O)NC(c3ccccc3)c3ccccc3)N2C1=O
E3 Binder	CHEMBL461456	ChEMBL	7.76	—	—	CN[C@@H](C)C(=O)N[C@H]1CN(C)CC[C@H]2CC[C@@H](C(=O)NC(c3ccccc3)c3ccccc3)N2C1=O
E3 Binder	CHEMBL506213	ChEMBL	8.01	—	—	CN[C@@H](C)C(=O)N[C@H]1CN(Cc2ccccc2)CC[C@H]2CC[C@@H](C(=O)NC(c3ccccc3)c3ccccc3)N2C1=O
E3 Binder	CHEMBL459541	ChEMBL	8.34	—	—	CN[C@@H](C)C(=O)N[C@H]1CNCC[C@H]2CC[C@@H](C(=O)NC(c3ccccc3)c3ccccc3)N2C1=O

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