KLH15

Details:

UniProt Entry: Q96M94
Gene: KLHL15
Class: Other E3 Components
Family: Adaptor
Protein length: 604
Database confidence: 0.625
InterPro: InterPro Entry
Mode of Action: unknown
AlphaFold Model: Link

Protein Sequence ▾

>Q96M94
MAGDVEGFCS SIHDTSVSAG FRALYEEGLL LDVTLVIEDH QFQAHKALLA TQSDYFRIMF
TADMRERDQD KIHLKGLTAT GFSHVLQFMY YGTIELSMNT VHEILQAAMY VQLIEVVKFC
CSFLLAKICL ENCAEIMRLL DDFGVNIEGV REKLDTFLLD NFVPLMSRPD FLSYLSFEKL
MSYLDNDHLS RFPEIELYEA VQSWLRHDRR RWRHTDTIIQ NIRFCLMTPT SVFEKVKTSE
FYRYSRQLRY EVDQALNYFQ NVHQQPLLDM KSSRIRSAKP QTTVFRGMIG HSMVNSKILL
LKKPRVWWEL EGPQVPLRPD CLAIVNNFVF LLGGEELGPD GEFHASSKVF RYDPRQNSWL
QMADMSVPRS EFAVGVIGKF IYAVAGRTRD ETFYSTERYD ITNDKWEFVD PYPVNKYGHE
GTVLNNKLFI TGGITSSSTS KQVCVFDPSK EGTIEQRTRR TQVVTNCWEN KSKMNYARCF
HKMISYNGKL YVFGGVCVIL RASFESQGCP STEVYNPETD QWTILASMPI GRSGHGVTVL
DKQIMVLGGL CYNGHYSDSI LTFDPDENKW KEDEYPRMPC KLDGLQVCNL HFPDYVLDEV
RRCN

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
1	137	Domain	Kelch-like protein 15, BTB/POZ domain	IPR030597	cd18244
1	597	Family	BTB-kelch protein	IPR017096	PIRSF037037
8	157	Homologous_superfamily	SKP1/BTB/POZ domain superfamily	IPR011333	G3DSA:3.30.710.10
9	125	Homologous_superfamily	SKP1/BTB/POZ domain superfamily	IPR011333	SSF54695
23	126	Domain	BTB/POZ domain	IPR000210	PF00651
31	98	Domain	BTB/POZ domain	IPR000210	PS50097
31	128	Domain	BTB/POZ domain	IPR000210	SM00225
128	235	Domain	Kelch-like protein 15, BACK domain	IPR047030	cd18454
133	237	Domain	BTB/Kelch-associated	IPR011705	SM00875
146	236	Domain	BTB/Kelch-associated	IPR011705	PF07707
269	594	Homologous_superfamily	Kelch-type beta propeller	IPR015915	G3DSA:2.120.10.80
285	588	Homologous_superfamily	Kelch-type beta propeller	IPR015915	SSF117281
328	379	Repeat	Kelch repeat type 1	IPR006652	SM00612
368	409	Repeat	Kelch repeat type 1	IPR006652	PF01344
380	426	Repeat	Kelch repeat type 1	IPR006652	SM00612
427	488	Repeat	Kelch repeat type 1	IPR006652	SM00612
477	529	Repeat	Kelch repeat type 1	IPR006652	PF01344
489	542	Repeat	Kelch repeat type 1	IPR006652	SM00612
532	572	Repeat	Kelch repeat type 1	IPR006652	PF01344
543	592	Repeat	Kelch repeat type 1	IPR006652	SM00612

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000120
GO:0006511	ubiquitin-dependent protein catabolic process	Biological Process	IDA	PMID:27561354
GO:0071630	nuclear protein quality control by the ubiquitin-proteasome system	Biological Process	IBA	GO_REF:0000033
GO:2000042	negative regulation of double-strand break repair via homologous recombination	Biological Process	IDA	PMID:27561354
GO:0005634	nucleus	Cellular Component	IEA	GO_REF:0000120
GO:0031463	Cul3-RING ubiquitin ligase complex	Cellular Component	IEA	GO_REF:0000002
GO:0005515	protein binding	Molecular Function	IPI	PMID:25036637
GO:1990756	ubiquitin-like ligase-substrate adaptor activity	Molecular Function	IDA	PMID:27561354

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