UB2E2

Details:

UniProt Entry: Q96LR5
Gene: UBE2E2
Class: Other E3 Components
Family: E2
Protein length: 201
Database confidence: 0.125
InterPro: InterPro Entry
Mode of Action: unknown
AlphaFold Model: Link

Protein Sequence ▾

>Q96LR5
MSTEAQRVDD SPSTSGGSSD GDQRESVQQE PEREQVQPKK KEGKISSKTA AKLSTSAKRI
QKELAEITLD PPPNCSAGPK GDNIYEWRST ILGPPGSVYE GGVFFLDITF SPDYPFKPPK
VTFRTRIYHC NINSQGVICL DILKDNWSPA LTISKVLLSI CSLLTDCNPA DPLVGSIATQ
YMTNRAEHDR MARQWTKRYA T

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
37	200	Homologous_superfamily	Ubiquitin-conjugating enzyme/RWD-like	IPR016135	SSF54495
46	201	Homologous_superfamily	Ubiquitin-conjugating enzyme/RWD-like	IPR016135	G3DSA:3.10.110.10
55	201	Domain	Ubiquitin-conjugating enzyme E2	IPR000608	PS50127
58	196	Domain	Ubiquitin-conjugating enzyme E2	IPR000608	cd00195
59	195	Domain	Ubiquitin-conjugating enzyme E2	IPR000608	PF00179
128	143	Active_site	Ubiquitin-conjugating enzyme, active site	IPR023313	PS00183

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0006974	DNA damage response	Biological Process	IMP	PMID:21628527
GO:0010629	negative regulation of gene expression	Biological Process	IDA	PMID:39096901
GO:1900087	positive regulation of G1/S transition of mitotic cell cycle	Biological Process	IGI	PMID:21628527
GO:0006513	protein monoubiquitination	Biological Process	IEA	GO_REF:0000117
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000041
GO:0032020	ISG15-protein conjugation	Biological Process	IBA	GO_REF:0000033
GO:0070534	protein K63-linked ubiquitination	Biological Process	IBA	GO_REF:0000033
GO:0070936	protein K48-linked ubiquitination	Biological Process	IBA	GO_REF:0000033
GO:0070979	protein K11-linked ubiquitination	Biological Process	IBA	GO_REF:0000033
GO:0005634	nucleus	Cellular Component	IBA	GO_REF:0000033
GO:0000166	nucleotide binding	Molecular Function	IEA	GO_REF:0000043
GO:0004842	ubiquitin-protein transferase activity	Molecular Function	IDA	PMID:20061386
GO:0005515	protein binding	Molecular Function	IPI	PMID:17460044
GO:0005524	ATP binding	Molecular Function	IEA	GO_REF:0000043
GO:0016740	transferase activity	Molecular Function	IEA	GO_REF:0000043
GO:0042296	ISG15 transferase activity	Molecular Function	IBA	GO_REF:0000033
GO:0061631	ubiquitin conjugating enzyme activity	Molecular Function	IBA	GO_REF:0000033

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