NSD1

Details:

UniProt Entry: Q96L73
Gene: NSD1
Class: RING
Family: RING10
Protein length: 2696
Database confidence: 0.125
InterPro: InterPro Entry
Mode of Action: Unclassified
AlphaFold Model: Link
PDB Structures: 3ooi, 6kqp, 6kqq

Protein Sequence ▾

>Q96L73
MDQTCELPRR NCLLPFSNPV NLDAPEDKDS PFGNGQSNFS EPLNGCTMQL STVSGTSQNA
YGQDSPSCYI PLRRLQDLAS MINVEYLNGS ADGSESFQDP EKSDSRAQTP IVCTSLSPGG
PTALAMKQEP SCNNSPELQV KVTKTIKNGF LHFENFTCVD DADVDSEMDP EQPVTEDESI
EEIFEETQTN ATCNYETKSE NGVKVAMGSE QDSTPESRHG AVKSPFLPLA PQTETQKNKQ
RNEVDGSNEK AALLPAPFSL GDTNITIEEQ LNSINLSFQD DPDSSTSTLG NMLELPGTSS
SSTSQELPFC QPKKKSTPLK YEVGDLIWAK FKRRPWWPCR ICSDPLINTH SKMKVSNRRP
YRQYYVEAFG DPSERAWVAG KAIVMFEGRH QFEELPVLRR RGKQKEKGYR HKVPQKILSK
WEASVGLAEQ YDVPKGSKNR KCIPGSIKLD SEEDMPFEDC TNDPESEHDL LLNGCLKSLA
FDSEHSADEK EKPCAKSRAR KSSDNPKRTS VKKGHIQFEA HKDERRGKIP ENLGLNFISG
DISDTQASNE LSRIANSLTG SNTAPGSFLF SSCGKNTAKK EFETSNGDSL LGLPEGALIS
KCSREKNKPQ RSLVCGSKVK LCYIGAGDEE KRSDSISICT TSDDGSSDLD PIEHSSESDN
SVLEIPDAFD RTENMLSMQK NEKIKYSRFA ATNTRVKAKQ KPLISNSHTD HLMGCTKSAE
PGTETSQVNL SDLKASTLVH KPQSDFTNDA LSPKFNLSSS ISSENSLIKG GAANQALLHS
KSKQPKFRSI KCKHKENPVM AEPPVINEEC SLKCCSSDTK GSPLASISKS GKVDGLKLLN
NMHEKTRDSS DIETAVVKHV LSELKELSYR SLGEDVSDSG TSKPSKPLLF SSASSQNHIP
IEPDYKFSTL LMMLKDMHDS KTKEQRLMTA QNLVSYRSPG RGDCSTNSPV GVSKVLVSGG
STHNSEKKGD GTQNSANPSP SGGDSALSGE LSASLPGLLS DKRDLPASGK SRSDCVTRRN
CGRSKPSSKL RDAFSAQMVK NTVNRKALKT ERKRKLNQLP SVTLDAVLQG DRERGGSLRG
GAEDPSKEDP LQIMGHLTSE DGDHFSDVHF DSKVKQSDPG KISEKGLSFE NGKGPELDSV
MNSENDELNG VNQVVPKKRW QRLNQRRTKP RKRMNRFKEK ENSECAFRVL LPSDPVQEGR
DEFPEHRTPS ASILEEPLTE QNHADCLDSA GPRLNVCDKS SASIGDMEKE PGIPSLTPQA
ELPEPAVRSE KKRLRKPSKW LLEYTEEYDQ IFAPKKKQKK VQEQVHKVSS RCEEESLLAR
GRSSAQNKQV DENSLISTKE EPPVLEREAP FLEGPLAQSE LGGGHAELPQ LTLSVPVAPE
VSPRPALESE ELLVKTPGNY ESKRQRKPTK KLLESNDLDP GFMPKKGDLG LSKKCYEAGH
LENGITESCA TSYSKDFGGG TTKIFDKPRK RKRQRHAAAK MQCKKVKNDD SSKEIPGSEG
ELMPHRTATS PKETVEEGVE HDPGMPASKK MQGERGGGAA LKENVCQNCE KLGELLLCEA
QCCGAFHLEC LGLTEMPRGK FICNECRTGI HTCFVCKQSG EDVKRCLLPL CGKFYHEECV
QKYPPTVMQN KGFRCSLHIC ITCHAANPAN VSASKGRLMR CVRCPVAYHA NDFCLAAGSK
ILASNSIICP NHFTPRRGCR NHEHVNVSWC FVCSEGGSLL CCDSCPAAFH RECLNIDIPE
GNWYCNDCKA GKKPHYREIV WVKVGRYRWW PAEICHPRAV PSNIDKMRHD VGEFPVLFFG
SNDYLWTHQA RVFPYMEGDV SSKDKMGKGV DGTYKKALQE AAARFEELKA QKELRQLQED
RKNDKKPPPY KHIKVNRPIG RVQIFTADLS EIPRCNCKAT DENPCGIDSE CINRMLLYEC
HPTVCPAGGR CQNQCFSKRQ YPEVEIFRTL QRGWGLRTKT DIKKGEFVNE YVGELIDEEE
CRARIRYAQE HDITNFYMLT LDKDRIIDAG PKGNYARFMN HCCQPNCETQ KWSVNGDTRV
GLFALSDIKA GTELTFNYNL ECLGNGKTVC KCGAPNCSGF LGVRPKNQPI ATEEKSKKFK
KKQQGKRRTQ GEITKEREDE CFSCGDAGQL VSCKKPGCPK VYHADCLNLT KRPAGKWECP
WHQCDICGKE AASFCEMCPS SFCKQHREGM LFISKLDGRL SCTEHDPCGP NPLEPGEIRE
YVPPPVPLPP GPSTHLAEQS TGMAAQAPKM SDKPPADTNQ MLSLSKKALA GTCQRPLLPE
RPLERTDSRP QPLDKVRDLA GSGTKSQSLV SSQRPLDRPP AVAGPRPQLS DKPSPVTSPS
SSPSVRSQPL ERPLGTADPR LDKSIGAASP RPQSLEKTSV PTGLRLPPPD RLLITSSPKP
QTSDRPTDKP HASLSQRLPP PEKVLSAVVQ TLVAKEKALR PVDQNTQSKN RAALVMDLID
LTPRQKERAA SPHQVTPQAD EKMPVLESSS WPASKGLGHM PRAVEKGCVS DPLQTSGKAA
APSEDPWQAV KSLTQARLLS QPPAKAFLYE PTTQASGRAS AGAEQTPGPL SQSPGLVKQA
KQMVGGQQLP ALAAKSGQSF RSLGKAPASL PTEEKKLVTT EQSPWALGKA SSRAGLWPIV
AGQTLAQSCW SAGSTQTLAQ TCWSLGRGQD PKPEQNTLPA LNQAPSSHKC AESEQK

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
321	387	Domain	PWWP domain	IPR000313	SM00293
323	388	Domain	PWWP domain	IPR000313	PS50812
324	412	Domain	PWWP domain	IPR000313	PF00855
1532	1587	Homologous_superfamily	Zinc finger, FYVE/PHD-type	IPR011011	SSF57903
1537	1588	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
1543	1589	Domain	Zinc finger, PHD-finger	IPR019787	PS50016
1545	1587	Domain	Zinc finger, PHD-type	IPR001965	SM00249
1589	1699	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
1592	1639	Domain	Zinc finger, PHD-type	IPR001965	SM00249
1640	1693	Domain	Zinc finger, PHD-type	IPR001965	SM00249
1695	1764	Homologous_superfamily	Zinc finger, FYVE/PHD-type	IPR011011	SSF57903
1700	1750	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
1707	1751	Domain	Zinc finger, PHD-finger	IPR019787	PS50016
1709	1749	Domain	Zinc finger, PHD-type	IPR001965	SM00249
1710	1748	Conserved_site	Zinc finger, PHD-type, conserved site	IPR019786	PS01359
1754	1816	Domain	PWWP domain	IPR000313	SM00293
1756	1818	Domain	PWWP domain	IPR000313	PS50812
1758	1844	Domain	PWWP domain	IPR000313	PF00855
1854	2082	Homologous_superfamily	SET domain superfamily	IPR046341	G3DSA:2.170.270.10
1863	2072	Homologous_superfamily	SET domain superfamily	IPR046341	SSF82199
1890	1941	Domain	AWS domain	IPR006560	SM00570
1890	1940	Domain	AWS domain	IPR006560	PS51215
1901	1939	Domain	AWS domain	IPR006560	PF17907
1942	2065	Domain	SET domain	IPR001214	SM00317
1942	2059	Domain	SET domain	IPR001214	PS50280
1953	2059	Domain	SET domain	IPR001214	PF00856
2066	2082	Domain	Post-SET domain	IPR003616	SM00508
2066	2082	Domain	Post-SET domain	IPR003616	PS50868
2096	2163	Homologous_superfamily	Zinc finger, FYVE/PHD-type	IPR011011	SSF57903
2104	2210	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
2120	2163	Domain	Zinc finger, PHD-type	IPR001965	SM00249
2161	2210	Domain	NSD, Cys-His rich domain	IPR041306	PF17982

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0032259	methylation	Biological Process	IEA	GO_REF:0000043
GO:0006338	chromatin remodeling	Biological Process	IEA	GO_REF:0000108
GO:0006325	chromatin organization	Biological Process	IEA	GO_REF:0000043
GO:0006355	regulation of DNA-templated transcription	Biological Process	IEA	GO_REF:0000117
GO:0033135	regulation of peptidyl-serine phosphorylation	Biological Process	IMP	PMID:20837538
GO:1903025	regulation of RNA polymerase II regulatory region sequence-specific DNA binding	Biological Process	IMP	PMID:20837538
GO:0000122	negative regulation of transcription by RNA polymerase II	Biological Process	ISS	GO_REF:0000024
GO:0045893	positive regulation of DNA-templated transcription	Biological Process	IDA	PMID:11509567
GO:0005634	nucleus	Cellular Component	IEA	GO_REF:0000044
GO:0005694	chromosome	Cellular Component	IEA	GO_REF:0000120
GO:0005654	nucleoplasm	Cellular Component	IEA	GO_REF:0000117
GO:0000785	chromatin	Cellular Component	IBA	GO_REF:0000033
GO:0008168	methyltransferase activity	Molecular Function	IEA	GO_REF:0000043
GO:0016740	transferase activity	Molecular Function	IEA	GO_REF:0000043
GO:0140999	histone H3K4 trimethyltransferase activity	Molecular Function	IEA	GO_REF:0000003
GO:0003712	transcription coregulator activity	Molecular Function	IEA	GO_REF:0000117
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0016922	nuclear receptor binding	Molecular Function	IEA	GO_REF:0000117
GO:0042054	histone methyltransferase activity	Molecular Function	IEA	GO_REF:0000002
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0046975	histone H3K36 methyltransferase activity	Molecular Function	IEA	GO_REF:0000117
GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Molecular Function	IDA	PMID:20837538
GO:0003682	chromatin binding	Molecular Function	ISS	GO_REF:0000024
GO:0003714	transcription corepressor activity	Molecular Function	ISS	GO_REF:0000024
GO:0005515	protein binding	Molecular Function	IPI	PMID:20080798
GO:0030331	nuclear estrogen receptor binding	Molecular Function	ISS	GO_REF:0000024
GO:0042799	histone H4K20 methyltransferase activity	Molecular Function	ISS	GO_REF:0000024
GO:0042974	nuclear retinoic acid receptor binding	Molecular Function	ISS	GO_REF:0000024
GO:0046965	nuclear retinoid X receptor binding	Molecular Function	ISS	GO_REF:0000024
GO:0046966	nuclear thyroid hormone receptor binding	Molecular Function	ISS	GO_REF:0000024
GO:0050681	nuclear androgen receptor binding	Molecular Function	IDA	PMID:11509567
GO:0140938	histone H3 methyltransferase activity	Molecular Function	TAS	Reactome:R-HSA-4827383
GO:0140954	histone H3K36 dimethyltransferase activity	Molecular Function	IEA	GO_REF:0000120

Enzyme–Substrate Interactions ▾

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